| Project/Area Number |
02045005
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | University-to-University Cooperative Research |
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| Research Institution | Yamagata University |
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Principal Investigator |
TAKAHASI Tuneo Second Department of Internal Medicine, Yamagata University School of Medicine, 医学部, 教授 (40004923)
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| Co-Investigator(Kenkyū-buntansha) |
JANN Daronn Shanghai Second Medical University, 内科, 副主任医師
JANN Detuon Shanghai Second Medical University, 内科, 副主任医師
胡 運彪 上海第二医科大学, 内科, 副教授
MISAWA Hiroyuki Second Department of Internal Medicine, Yamagata University School of Medicine, 医学部・附属病院, 助手 (90211581)
SAITO Hideki Second Department of Internal Medicine, Yamagata University School of Medicine, 医学部, 助手 (70186948)
AJITU Shin Second Department of Internal Medicine, Yamagata University School of Medicine, 医学部・附属病院, 講師 (80159392)
HU Yun Biaou Second Department of Internal Medicine, Yamagata University School of Medicine
江 紹基 上海第二医科大学, 消化器内科, 教授
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1991: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1990: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Ulcerative Colitis / Saireito / 柴苓湯 / 好中球化学発光 / 漢方治療 / サイトカイン / リンパ球機態 / 疫学調査 |
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| Research Abstract |
Ulcerative colitis (UC) is supposed to have the immunological abnormalities and is treated mainly with salicyl-azosulfapyridine (SASP) and corricosteroid hormone (CS). We investigated the effect of Saireito (Chinese traditional medicine) on improving the immunological deficiency of the chemiluminescent response (CL) and cultured T lymphocyte function derived from UC patient.
One third patient with active UC stage were improved by Saireito therapy combined with CS or SASP. The activity of CL was increased in UC group compared with healthy control group. The CL activities were decreased after p. o. administration of Saireito.
The cultured T cell line derived from active UC patients were expressed CD4 positive marker and more responded CD3 antibody compared with control group. Saireitou was efficient to suppress the proliferative response in vitro. The production of TNF in established T cell line from UC patient was higher than the cell line from normal mucosa. The production of TNF was also suppressed by Saireito solution similar to corticosteroid effect.
Saireito suppressed the CL activities of neutrophils after p. o. administration. The study on T cell lymmphocyte function suggested the possibility that Saireito has some influence on immune function. On the basis of these results, we suggest that Saireito might be able to use treatment of UC not only for reducing the dose of CS or SASP but improving the immune deficiency of UC.
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