MAEZIMA Kazuyoshi Keio University, Department of medical science, Professor., 医学部, 教授 (70051464)
NAMIOKA Shigero Hokkaido University, Department of Veterinary science, Professor., 獣医学部, 教授 (10002297)
TAKEUCHI Akira TOKYO University, Department of Agriculture science, Professor., 農学部, 教授 (90011874)
MITSUOKA Tomotari Nippon Veterinary and Animal science University, department of Food science and, 食品工学科, 教授 (30157549)
KOSAKA Futami Okayama University medical school, Professor emeritus., 医学部, 名誉教授 (00032847)
|Budget Amount *help
¥14,600,000 (Direct Cost : ¥14,600,000)
Fiscal Year 1992 : ¥1,400,000 (Direct Cost : ¥1,400,000)
Fiscal Year 1991 : ¥4,500,000 (Direct Cost : ¥4,500,000)
Fiscal Year 1990 : ¥8,700,000 (Direct Cost : ¥8,700,000)
We were get a following results.
1). We were established method of anesthesia in experimental animals, for instance mouse, rat, hamster, guinea pig, rabbit and pigs.
2). It's method are make a critical commentary upon the anesthesiology, ethics and animal welfare. (1) And then it's a new method as pain relief in animal experimentation. (2) Also method of animal handling, fixation and selected sedative medicine, analgesics in premedication. (3) Selected (injectable and inhalation) anesthetics, determins of use doses in pre, during and post operative stage. (4) Development of Electronic control anesthetics vaporizing system (ECAVS) in small and middle size experimental animals.
3). It's new method are make a critical commentary upon the physiological and biochemistry, for example respiratory rate, pulse, body temperature, blood pressure, electro cardio graph (ECG), electro encepharo graph (EEG), concentration of inspiratory and expiratory anesthetics gases, pH, PCO_2, PO_2, HCO_3, O_2 SAT., base excess, total CO_2, O_2 content in blood were mesured.
4). It is established diffusing anesthetics method in each experimental animals.