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Role of magnesium on prevention of diseases.

Research Project

Project/Area Number 02305005
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

ITOKAWA Yoshinori  Fac. of Med., Kyoto Univ., Professor, 医学部, 教授 (80025593)

Co-Investigator(Kenkyū-buntansha) SAITO N  Kochi Med. Sch., Associate Professor, 助教授 (40026886)
MORII H  Osaka City Univ. Med. Sch., Professor, 医学部, 教授 (40046983)
YANO H  Fac. of Agr., Kyoto Univ., Professor, 農学部, 教授 (20026587)
KOBAYASHI A  Showa Med. Univ., Professor, 医学部, 教授 (30153589)
KIMURA M  Fac. of Med., Kyoto Univ., Assoc. Prof., 医学部, 助教授 (60025658)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥19,500,000)
Fiscal Year 1992: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1991: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1990: ¥10,000,000 (Direct Cost: ¥10,000,000)
KeywordsMagnesium intake / PTH / Uremic rat / Diabetes mellitus / Cardiovascular disease / Cyclosporine / シクロスポリン / マグネシウム / 食事調査 / 単身赴任者 / ストレス / リン / SHRSR / QT延長症候群 / マグネシウム欠乏 / ミネラルバランス異常 / PTH / 血清マグネシウム値 / 利尿剤 / 糖尿病 / 成人病 / 尿中カルシウム / マグネシウム比 / カルシウム / ゲルマニウム / 全身骨塩量 / 血液透析
Research Abstract

This cooperative research was carried out to clarify the effect of magnesium on prevention of various diseases through survey , experimental and clinical studies. Dietary survey studies were carried out in various groups in Japan and magnesium intakes were calculated using personal computer program made by our group. Magnesium intake per day in most of the groups were less than 300 mg. In experimental studies. it was clarified that unbalance of various minerals were occurred in many tissues of magnesium deficient rats. By high phosphorus diet, serum PTH increased , content of 1,25(OH)_2D_3 in serum decreased and renal calcification was increased. These changes were prevented by the addition of dietary magnesium.The acute cold exposure was achieved by immersing sheep in cold water. Plasma magnesium levels increased from 30 minutes after the beginning of cold exposure. Plasma creatinine levels increased immediately after the beginning of cold exposure which suggested that glomerular filtration rate was decreased in cold exposure sheep.In 5/6-nephrectomized uremic model, hypocalcemia was observed in magnesium deficient rats. Infusion study clearly demonstrated that PTH secretion was increased in magnesium deficient uremic rats. By the long term administration of MgCl_2 as drinking water to SHRSP, cerebral softening or small bleeding was prevented . In clinical studies, it was found that patients with diabetes mellitus or cardiovascular disease showed significant decrease of serum magnesium. By the studies on pathogenesis of cyclosporine-induced hypomagnesemia, it was clarifed that cyclosporine induces on intracellular shift of magnesium. In young long distance runner, exercise caused a decrease in urinary calcium and magnesium.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 二村 嘉毅: "Ca給源とミネラル出納" マグネシウム. 10. 201-210 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 西牟田 守: "男子陸上長距離選手を対象としたミネラルの代謝出納実験" マグネシウム. 10. 243-253 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 木村 美恵子: "鉄摂取量の違いによるマグネシウム欠乏ラットの血清生化学性状の変化" マグネシウム. 11. 19-29 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Noboru Saito: "The relationshin among nagnesium potassium,aldosterone and chatecholanine in 24-hour urine of fomale outpatients." マグネシウム. 11. 31-38 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 糸川 嘉則: "Ca,Mgと脳の動脈硬化" 実験治療. 627. 66-68 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 糸川 嘉則: "Chronic fatigue syndromeに対するマグネシウム療法" 医学のあゆみ. 163. 898 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Goto, S.: "Effect of dietary calcium sources on mineral balance in rats." J. Jap. Soc. Mg Res.10. 201-210 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nishimuta. M.: "A mineral balance study in male long distance runners." J. Jap. Soc. Mg Res.10. 243-253 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kimura,M., Itokawa,Y.: "Effects of iron intake on serum biochemical parameters in magnesium deficient rats." J. Jap. Soc. Mg Res.11. 19-29 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Saito, N.: "The relationship among magnesium, potassium, aldosterone and catecholamine in 24-hour urine of female outpatients." J. Jap. Soc. Mg Res.11. 31-38 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Itokawa, Y.: "Magnesium therapy on chronic fatigue syndrome." Igaku no Ayumi. 163. 898-897 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Itokawa, Y.: "Calcium, magnesium and atherosclerosis in brain." Experiment & Therapy. 627. 66-68 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 木村 美恵子: "鉄摂取量の磯いによるマグネシウム欠乏ラットの血清生化学性状の変化" マグネシウム. 11. 19-29 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Noboru Saito: "The relationship among magnesium potassium,aldosterone and chatecholamine in 24-hour urine of female outpAtients" マグネシウム. 11. 31-38 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Noboru Saito: "Calcium and magnesium in heart,skeletal muscle,kidney and liver of male mouse with hypervitaminosis A." マグネシウム. 11. 51-57 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 上原 万里子: "食事性P,Mgレベルが生体内Fe,Cu,Zn濃度に及ぼす影響" マグネシウム. 11. 145-153 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 糸川 嘉則: "Ca,Mgと脳の動脈硬化" 実験治療. 627. 66-68 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 糸川 嘉則: "Chronic fatigue syndromeに対するマグネシウム療法" 医学のあゆみ. 163. 898 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 糸川 嘉則: "我が国におけるマグネシウム研究の過去,現在,未来" マグネシウム. 10. 3-6 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木村 美恵子: "マグネシウム欠乏ラットの生体内ミネラルバランスに及ぼす鉄摂取量の影響" マグネシウム. 10. 19-27 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西村 剛: "急激な寒冷感作がめん羊の血中マグネシウム濃度に及ぼす影響" マグネシウム. 10. 29-38 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Noboru Saito: "The effect of intravenous administration of magnesium chloride on blood flow of rat carotid artery." マグネシウム. 10. 193-200 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 二村 嘉毅: "Ca給源とミネラル出納" マグネシウム. 10. 201-210 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西牟田 守: "男子陸上長距離選手を対象としたミネラルの代謝出納実験" マグネシウム. 10. 243-253 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 児玉 直子: "マグネシウム摂取量の把握方法について" マグネシウム. 9. 1-5 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 内田 典芳: "1,25ーdihydroxycholecalciferol投与がめん羊の血中マグネシウム濃度に及ぼす影響" マグネシウム. 9. 29-37 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 美恵子: "ラット生体内マグネシウム及びその他ミネラルへのゲルマニウム投与の影響" マグネシウム. 9. 49-59 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Noboru Saito: "The influence of longーterm drinking of MgCl_2 solution on cerebral vascular lesions in SHRSP." マグネシウム. 9. 77-84 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Itokawa: "Effects of Cellulose on Thiamin and Magnesium Metabolism in Magnesium Deficient Rats" マグネシウム. 9. 101-108 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 奥野 仙二: "食餌中Mg含量のラット全身骨塩量に及ぼす影響" マグネシウム. 9. 109-114 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 糸川 嘉則: "妊婦のためのビタミン・ミネラル読本" メディカ出版, 187 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 糸川 嘉則: "栄養の生理学" 裳華房, 131 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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