| Project/Area Number |
02453137
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
SHIBASAKI Masakatsu Hokkaido Univ.Fac.Pharamac.Sci・Professor, 薬学部, 教授 (30112767)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATO Yoshihiro Hokkaido Univ.Fac.Pharmac.Sci・Instructor, 薬学部, 教務職員 (90226019)
SASAI Hiroaki Hokkaido Univ.Fac.Pharmac.Sci・Instructor, 薬学部, 助手 (90205831)
袖岡 幹子 北海道大学, 薬学部, 助手 (60192142)
|
|---|
| Project Period (FY) |
1990 – 1991
|
| Project Status |
Completed (Fiscal Year 1991)
|
| Budget Amount *help |
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1990: ¥4,400,000 (Direct Cost: ¥4,400,000)
|
|---|
| Keywords | Heck Reaction / Catalytic Asymmetric Synthesis / Decalin Derivatives / Hydrindan Derivatives / Capnellenol / Marine Natural Product / カプネレノ-ル / 不斉ヘック反応 / 不斉πーアリルパラジウム / カプネランアルコ-ル / アザディラクチン |
|---|
| Research Abstract |
Previously we developed an asymmetric Heck reaction, in which the cis-decalin derivative was obtained in 45% ee. Now we have succeeded in improving the above-mentioned asymmetric Heck reaction as shown below.
Furthermore, we have accomplished a catalytic asymmetric synthesis of capnellenols 5 and 6 by utilizing an asymmetric Heck reaction. On the other hand, the cis-decalin derivative 7 has been found to be synthesized in 83% ee through the pi-allylpalladium intermediate.
|
