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A study on autoimmune mechanism in the pathogenesis of myocarditis of cardiomyopathy analysis by anti-heart monoclonal antibody

Research Project

Project/Area Number 02454255
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKyoto University

Principal Investigator

MATSUMORI Akira  Kyoto University Dep. of Internal Med. Assistant Professor, 医学部, 講師 (70135573)

Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1991: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1990: ¥3,300,000 (Direct Cost: ¥3,300,000)
KeywordsCardiomyopathy / Myocarditis / Virus / Autoantibody / Anti-heart antibody / Auto-immunity / Monoclonal antibody / Hybridoma / 心筋炎 / ハイブリド-マ
Research Abstract

In order to clarify the role of antiheart antibody in the pathogenesis of myocarditis and cardiomyopathy, we analyzed anti-heart antibody by developing monocional antibodies. Anti-heart autoantibodies were found in the sera from Balb/c mice with myocarditis infected with encephalomyocarditis (EMC) virus. Frozen sections of the hearts of uninfected mice were incubated with mouse sera and stained with anti-mouse lgG and lgM. Positive granular staining was first seen on day 4 and persisted to day 90 ; the titer was highest on day 21. Spleen cells from mice with positive anti-heart antibody on day 21 at post-infection were fused with a cell line of plasmacytoma. Supernatants of hybridoma were screened by immunoflurerescence against murine heart sections. Two clones of lgM-producing hybridoma were developed ; one clone IA5, stained myocytes with striated pattern and the other clone IB5, stained endothelial cells. Results from western immunoblotting analyses demonstrated that IA5 reacted with cardiac myosin. These studies suggest that myosin is one of the major autoantigens in EMC virus myocarditis.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (66 results)

All Other

All Publications (66 results)

  • [Publications] Tamaki N: "Indium-111-antimyosin antibody imaging for detecting different stages of myocardial infarction:Comparison with technetium-99m pyrophosphate imaging." J Nucl Med. 31. 136-142 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "Cardiomyopathy." Asian Med J. 33. 275-282 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "^<111>In monoclonal antimyosin antibody imaging:Imaging of myocardial infarction and myocarditis." Jpn Circ J. 54. 333-338 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matoba Y: "A case of biopsy-proven myocarditis progressing to autopsy-proven dilated cardiomyopathy." Clin Cardiol. 13. 732-737 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yamada T: "Pharmacokinetics of indium-111-labeled antimyosin monoclonal antibody in murine experimental viral myocarditis." J Am Coll Cardiol. 16. 1280-1286 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Okada I: "The viral gemone in experimental murine coxsackievirus B3 myocarditis:A northern blotting analysis." J Mol Cell Cardiol. 22. 999-1008 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Horike K: "Relation botween myoglobin and cardiac dysfunction in myocarditis:Immunohistochemical study of endomyodial biopsy specimens." Jpn Circ J. 55. 24-32 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "Pathogenesis of myocardial injury in myocarditis and cardiomyopathy." Jpn Circ J. 55. 1132-1137 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sato Y: "Effect of immunostimulant therapy on acute viral Myocarditis in an animal model." Am Heart J.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "A questionnaire study of β-adrenergic blockade in dilated cardiomyopathy in Japan." Jpn Circ J.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Okada I: "Successive infection of coxsackievirus B3 and encephalomyocarditis virus:An animal model of chronic myocarditis." J Pathol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matoda Y: "The effect of cyclosporine on the immunopathogenesis of viral myocarditis in mice." Jpn Circ J. 55. 407-416 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "Prognostic significance of indium-111 antimyosin antibody uptake in patients with dilated and hypertrophic cardiomyopathy." Int J Cardiol. 32. 75-82 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yamada T: "Detection of adriamycin cardiotoxicity with indium-111 labeled antimyosin monoclonal antibody imaging." Jpn Circ J. 55. 377-383 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "Immunomodulating therapy in viral myocarditis:Effects of tumor necrosis factor,interleukin 2 and anti-interleukin-2 receptor antibody in an animal model." Eur Heart J. 12(Suppl D). 203-205 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tominaga M: "β-blocker treatment of dilated cardiomyopathy:Beneficial effect of carteolol in an animal model." Circulation. 83. 2021-2028 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takemura G: "Expression and distribution of atrial natriuretic polypeptide in human hypertrophic ventricle of hypertensive hearts and hearts with hypertrophic cardiomyopathy." Circulation. 83. 181-190 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "In Proceeding of the 2nd international symposium on cardiomyopathy and myocarditis.Morphological features and electric disturbances in experimental viral myocarditis." University of Tokyo Press, 6(217-222) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "In advances in cardiomyopathies.Experimental viral myocarditis:Immunopathogenetic aspects." Springer-Verlag, 9(181-189) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "The effect of beta-adrenergic blockade in dilated cardiomyopathy:A questionnaire study in Japan." Heart and Vessels,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "In Viral infections of the heart.Experimental studies." Edward Arnold,Kent England,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "In Cardiomyopathy Update 4.Cardiomyopathy:Its metabolic and molecular aspects.Antimyosin monoclonal antibody uptake in myocarditis:Clinical and experimental studies." University of Tokyo Press, 6(219-234) (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "In Patholohy of Laboratory Animals.Myocarditis due to coxsackievirus B3,mouse." Springer-Verlag, 3(53-55) (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "Mechanism and significance of myocardial uptake of antimyosin antibody in myocarditis and cardiomyopathy:Clinical and experimental studies." Springer-Verlag,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsumori A: "International Symposium on Ldiopathic Dilated Cardiomyopathy.Animal models for therapeutic trials of viral myocarditis." Springer-Verlag,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Akiro Matsumori, Ikutaro Okada, Takehiko Yamada Shingo Maruyama, Chuichi Kawai: "Pathogenesis of myocardial injury in myocarditis and cardiomyopathy" Jpn Circ J. 55(11). 1132-1137 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matoba Y: "The effect of cyclosporine on the immunopathogenesis of Viral myocarditis in mice." Jpn Circ J. 55. 407-416 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Matsumori A: "Prognostic significance of indiumー111 antimyosin antibody uptake in patients with dilated and hypertrophic cardiomyopathy." Int J Cardiol. 32. 75-82 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yamada T: "Detection of adriamycin cardiotoxicity with induumー111 labeled antimyosin monoclonal antibody imaging" Jpn Circ J. 55. 377-383 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Matsumori A: "Immunodulating therapy in viral myocarditis:Effects of tumor necrosis factor,interleukin 2 and antiーinterleukinー2 receptor antibody in an animal model." Eur Heart J. 12 (Suppl D). 203-205 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tominaga M: "βーblocker treatment of dilated cardiomyopathy:Beneficial effect of carteolol in an animal model." Circulation. 83. 2021-2028 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takemura G: "Expression and distribution of atrial natriuretic polypeptide in human hypertrophic ventricle of hypertensive hearts and hearts with hypertrophic cardiomyopathy." Circulation. 83. 181-190 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Horike K: "Relation between myoglobin and cardiac dysfunction in myocarditis:Immunohistochemical study of endomyocardial biopsy specimens." Jpn Circ J. 55. 24-32 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Matsumori A: "Pathogenesis of myocardial injury in myocarditis and cardiomyopathy." Jpn Circ J. 55. 1132-1137 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sato Y: "Effect of immunostimulant therapy on acute viral myocarditis in an animal model." Am Heart J.

    • Related Report
      1991 Annual Research Report
  • [Publications] Matsumori A: "A questionnaire study of βーadrenergic blockade in dilated cardiomyopathy in Japan." Jpn Circ J.

    • Related Report
      1991 Annual Research Report
  • [Publications] Okada I: "Successive infection of coxsackievirus B3 and encephalomyocarditis Virus:An animal model of chronic myocarditis." J Pathol.

    • Related Report
      1991 Annual Research Report
  • [Publications] Matsumori A: "In Cardiomyopathy Update 4.Cardiomyopathy:Its metabolic and molecular aspects.Antimyosin monoclonal antibody uptake in myocarditis:Clinical and experimental studies." University of Tokyo Press, 6(219-234) (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Matsumori A: "In Pathology of Laboratory Animals.Myocarditis due to coxsackievirus B3,mouse." SpringerーVerlag, 3(53-55) (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Matsumor A: "The effect of betaーadrenergic blockade in dilated cardiomyopathy:A questionnaire study in Japan." Heart and Vessels,

    • Related Report
      1991 Annual Research Report
  • [Publications] Matsumori A: "In Viral infections of the heart.Experimental studies." Edward Arnold,Kent England,

    • Related Report
      1991 Annual Research Report
  • [Publications] Matsumori A: "Mechanism and significance of myocardial uptake of antimyosin antibody in myocarditis and cardiomyopathy:Clinical and experimental studies." SpringerーVerlag,

    • Related Report
      1991 Annual Research Report
  • [Publications] Matsumori A: "International Symposium on Idiopatic Dilated Cardiomyopathy.Animal models for therapeutic trials of viral myocarditis." SpringerーVerlag,

    • Related Report
      1991 Annual Research Report
  • [Publications] Tamaki N: "Indiumー111ーantimyosin antibody imaging for detecting different stages of myocardial infarction:Comparison with technetiumー99m pyrophosphate imaging." J Nucl Med. 31. 136-142 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsumori A: "Cardiomyopathy." Asian Med J. 33. 275-282 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsumori A: " ^<111>In monoclonal antimyosin antibody imaging:Imaging of myocardial infarction and myocarditis." Jpn Circ J. 54. 333-338 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Matoba Y: "A case of biopsyーproven myocarditis progressing to autopsyーproven dilated cardiomyopathy." Clin Cardiol. 13. 732-737 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yamada T: "Pharmacokinetics of indiumー111ーlabeled antimyosin monoclonal antibody in murine experimental viral myocarditis." J Am Coll Cardiol. 16. 1280-1286 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Okada I: "The viral gemone in experimental murine coxsackievirus B3 myocarditis:A northern blotting analysis." J Mol Cell Cardiol. 22. 999-1008 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsumori A: "Persistent uptake of indiumー111ーantimyosin monoclonal antibody in patients with myocardial infarction." Am Heart J. 120. 1026-1030 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Matoba Y: "The effect of cyclosporine on the immunopathogenesis of viral myocarditis in mice." Jpn Circ J.

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsumori A: "Immunomodulating therapy in viral myocarditis:Effects of tumor necrosis factor,interleukinー2 and antiーinterleukinー2 receptor antibody in an animal model." Eur Heart J.

    • Related Report
      1990 Annual Research Report
  • [Publications] Yamada T: "Detection of adriamycin cardiotoxicity with indiumー111 labeled antimyosin monoclonal antibody imaging." Jpn Circ J.

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsumori A: "Pathogenesis of myocardial injury in myocarditis and cardiomyopathy." Jpn Circ J.

    • Related Report
      1990 Annual Research Report
  • [Publications] Tominaga M: "βーblocker treatment of dilated cardiomyopathy:Beneficial effect of carteolol in an animal model." Circulation.

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsumori A: "Prognostic significance of indiumー111 antimyosin antibody uptake in patients with dilated and hypertrophic cardiomyopathy." Int J Cardiol.

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsumori A: "The effect of betaーadrenergic blockade in dilated cardiomyopathy." Heart and Vessels.

    • Related Report
      1990 Annual Research Report
  • [Publications] 山田 武彦: " ^<111>Inー標識抗ミオシンモノクロ-ナル抗体ーFabイメ-ジングの臨床応用(第4報):急性心筋梗塞における再潅流の影響" 核医学. 27. 133-138 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山田 武彦: " ^<111>Inー標識抗ミオシンモノクロ-ナル抗体ーFabイメ-ジングの臨床応用(第5報):反復検査における画像の変化、安全性の検討" 核医学. 27. 765-772 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松森 昭: "心筋症・心筋炎における ^<111>Inー標識抗ミオシンモノクロ-ナル抗体シンチグラフィ-" 核医学. 27. 1129-1134 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松森 昭: " ^<111>InーAntimyosin Fabを用いた心筋シンチグラフィの臨床応用(多施設による共同研究)" 核医学. 27. 1419-1432 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsumori A: "In Proceeding of the 2nd international symposium on cardiomyopathy and myocarditis.Morphological features and electric disturbances in experimental viral myocarditis." University of Tokyo Press, 6(pp.217-222) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsumori A: "In advances in cardiomyopathies.Experimental viral myocarditis:Immunopathogenetic aspects." SpringerーVerlag, 9(pp.181-189) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsumori A: "In Cardiomyopathy Uptake 4.Cardiomyopathy:Its metabolic and molecular aspects.Antimyosin monoclonal antibody uptake in myocarditis:Clinical and experimantal studies." University of Tokyo Press,

    • Related Report
      1990 Annual Research Report
  • [Publications] 松森 昭: "Annual Review 循環器 1990 心筋炎から心筋症へ" 中外医学社, (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松森 昭: "Annual Review 循環器 1991 心筋炎の免疫抑制療法" 中外医学社, (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2019-02-28  

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