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Studies on mechanism of tissue recovery by protective agents

Research Project

Project/Area Number 02454288
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

TSUBOI Atsushi (1991-1992)  N.I.R.S.,Head of Section, 障害基礎研究部, 室長 (30163869)

青木 芳朗 (1990)  放射線医学総合研究所, 障害臨床研究部, 部長 (50175741)

Co-Investigator(Kenkyū-buntansha) 色田 幹雄  放射線医学総合研究所, 薬理化学研究部, 部長 (00162579)
安藤 興一  放射線医学総合研究所, 臨床研究部, 室長 (00159526)
青木 芳朗  東京大学, 医学部, 教授 (50175741)
SHIKITA M  N.I.R.S.,Head of Division
AOKI Y  Tokyo Univ. Professor
ANDO K  N.I.R.S.,Head of Section
稲山 誠一  慶応義塾大学, 医学部, 教授 (30051030)
大原 弘  放射線医学総合研究所, 障害基礎研究部, 室長 (20160608)
坪井 篤  放射線医学総合研究所, 障害基礎研究部, 室長 (30163869)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1990: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsLO9018 / OK-432 / 5-FU / ZR-14 / Repair of radiation / injury / Hemopoietic Stem Cell / Radioprotection / 放射線防護効果 / ピカロカテキンガレ-ト / OKー432 / 組換体ILー6 / エトポシド / 造血幹細胞の回復促進 / 放射線防護剤 / 放射線回復剤 / okー432 / Lactobacillus casei(LC 9098) / ILー1 / ベスタチン / WRー151327 / メチルアミド系合成薬剤
Research Abstract

Recently many cytokines have been cloned as human recombinant (rH) and biological response modifiers (BRM) have been became available to human application. Such substances may be useful as radioprotective agents for human or improvement of hematopoietic radiation hazards which were induced during radiotherapy of cancer.
The objective of this report is to investigate radioprotective responses of some cytokines (rH-IL-1, rH-IL-6, rH-G-CSF), BRM (LO908, OK-432, Itoposide) and other agents in order to contribute further to improvement of hematopoietic radiation injury in radiotherapy of cancer.
Radioprotective activity for survivals of irradiated mice and enhancement of recovery for CFU-S or GM-CFC of marrow or spleen in irradiated mice by LO9018 and OK-432 were demonstrated when they were injected into mice 1 hr before irradiation. The injection of Itoposide into irradiated mice resulted in enhancement of recovery for the marrow cells. When rH-IL-1 was injected into mice 1 hr before irradiation or rH-IL-6 was injected into mice 1 hr after irradiation with a dose of 3 Gy, complete recovery from radiation injurys of hematopoietic stem cells was observed 7 days after the irradiations. Almost similar results were obtained for mice administered with rH-G-CSF. Radioprotective activity of mice by 5-FU was discovered when it was injected into mice 5 days before irradiation. The radiation source above used was low LET radiation. However, we also found out a radioprotective agent of WR151327 which was useful for high LET radiation. Studies on a new promising agent(ZR-14) for radioprotection is in progress.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] H.Sakagami,Y.Kuroiwa,M.Takeda,H.Ota,T.Naoe,M.Shikita: "Distribution of TNF endogenously induce by various immunopotentiators and Lactobacillus Casei in mice." In Vivo. 6. 247-254 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Ishihara,K.Tsuneoka,A.B.Dimchev,M.Shikita: "Induction of the expression of the interleukin-1 gene in mouse spleen by ionizing radiation." Radiation Research. 133. 321-326 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] E.Kojima,A.Tsuboi: "Protection of survival and hematopoies is in irradiated mice by 5-fluorouracil" Japanese Journal of Cancer Research. 83. 782-788 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] E.Kojima,A.Tsuboi: "Effects of 5-fluorouracil on hematopoietic stem cells in normal and irradiated mice." Journal of Radiation Research. 33. 218-226 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Sakagami, Y.Kuroiwa, M.Takeda, H.Ota--, T.Naoe, M.Shikita: "Distribution of TNF endogenously induce by various immunopotentiators and Lactobacillus Casein in mice" In Vivo. 6. 247-254 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Ishihara, K.Tsuneoka, A.B.Dimchev, M.Shikita: "Induction of the expression of the interleukin-1 gene in mouse spleen by ionizing radiation" Radiation Research. 133. 321-326 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] E.Kojima and A.Tsuboi: "Protection of survival and hematopoiesis in irradiated mice by 5-fluorouracil" Japanese Journal of Cancer Research. 83. 782-788 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] E.Kojima and A.Tsuboi: "Effects of 5-fluorouracil on hematopoietic stem cells in normal and irradiated mice" Journal of Radiation Research. 33. 218-226 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Sakagami,Y.Kuroiwa M.Takeda,H.Ota,K.Kazama T.Naoe,‐‐,M.Shikita: "Distribution of TNF endogenously inducel by various immu nopotentiators and Lactobacillus Casei in mice." In Vivo. 6. 247-254 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Ishihara,K.Tsuneoka A.B.Dimchev,M.Shikita: "Induction of the expression of the interleukin-1β gene in mouse spleen by ionizing radiation." Radiation Research. 133. 321-326 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] E.Kojima,A.Tsuboi: "Protection of survival and hematopoiesis in irradiated mice by 5-fluorouracil." Japanese Journal of Cancer Research. 83. 782-788 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] E.Kojima,A.Tsuboi: "Effects of 5-fluorouracil on hematopoietic stem cells in normal and irradiated mice." Journal of Radiation Research. 33. 218-226 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Z.Pojda,Y.Aoki,E.Machaj,E.Sobiczewska,A.Tsuboi: "In Vivo Administration of Interleukin 6 Delays Hematopoietic Regeneration in Sublethally Irradiated Mice" Experimental Hematology. (1993)

    • Related Report
      1991 Annual Research Report
  • [Publications] Z.Pojda,K.Tanaka,Y.Aoki,A.Tsuboi: "In Vivo and In Vitro Interaction Between Interleukin 6 and Granulocyte Colony-Stimulating Factor in the Regulation of the Mouse Hematopoiesis" Experimental Hematology. (1993)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Jibu,K.Ando,T.Matsumoto,S.Koike.O.Kobori,Y.Morioka.S.Kanegasaki: "Active Components of Intestinal Bacteria for Abdominal Irradiation-induced Inhibition of Lung Metastases" Clinical Experimental Metastasis. 9. 529-540 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 安藤 興一,山田 滋,小池 幸子: "放射線と抗癌剤の相互作用" 癌の臨床. 14. 1603-1607 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Uchida,M.Ozaki,K.Suzuki,M.Shikita: "Radioprotective Effects of (-)-Epigallocatechin 3-0-Gallate(Green-Tea) in Mice" Life Sciences. 50. 147-152 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Kobayashi,H.Abe,T.Ueyama,A.Awaya,M.Shikita: "Radioprotective Effects of Serum Thymic Factor in Mice" Radiation Research. 129. 1-6 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Tanikawa,M.Nose,<Y.Aoki>___ー,K.Tsuncoka,<M.Shikita>___ー,N.Nara: "Effects of Recombinant Human Granulocyte Colonyーstimulating Factor on the Hematologic.Recovery and Survival of Irradiated Mice." Blood. 76. 445-449 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Nomoto,T.Yokokura,K.Tsuneoka,<M.Shikita>___ー: "Radioprotection of Mice by a Single Subcutaneous Injection of HeatーKilled Lactovacilles casei after Irradiation." Radiation Research. 125. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Z.Pojda,<A.Tsuboi>___ー: "In vivo Effects of Recombinant Interleukin 6 on Hematopoietic Stem and Progenitor Cells and Circulating Blood Cells in Normal Mice." Experimental Hematology. 18. 1034-1037 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] S.Yamada,<K.Ando>___ー,S.KoiKe,K.Isono: "Etoposide Protects Mice from Radiationーinduced Bonemarrow Death." Japanese Journal of Cancer Reseach. 81. 112-114 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 安藤 興一: "基礎面から見た腫瘍治療ー腫瘍幹細数の重要性についてー" 癌の臨床. 36. 2223-2226 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Z.Pojda,<Y.AOKI>___ー,<A.Tsuboi>___ー: "In vivo Administration of Interleukin 6 Delays Hematopoietic Regeneration in Sublethally Irradiated Mice." Experimental Hematology.

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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