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Parameters associated with vulnerability of nerve fibers to glaucomatous damage.

Research Project

Project/Area Number 02454403
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKyoto University

Principal Investigator

CHIHARA Etsuo  Kyoto Univ. Medicine Assistant Professor, 医学部, 講師 (20111958)

Co-Investigator(Kenkyū-buntansha) 大平 明弘  京都大学, 医学部, 助手 (00169054)
OKINAMI Satoshi  Saga Medical School Medicine Associate Professor, 医学部, 助教授 (70089100)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1991: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1990: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsGlaucoma / Optic disc / Visual field / Retinal nerve fiber layer defect / 3-dimensional image analysis / Scanning laser Ophthalmoscope / Cotton wool spot / Axonal transport / レ-ガ-走査眼底鏡 / 軸索輸送 / 視神経 / 画像解析
Research Abstract

Glaucoma is one of the most important disease which cause blindness in Japan. The intraocular pressure is one of the most important parameter for the nerve loss. However, the degree of the nerve loss varies from patient to patient. This variable degree of vulnerability to glaucomatous damage is an enigma for ophthalmologist, even though which is important for clinical practice. It was our clinical impression that topographic variation of the optic disc is a factor for this variable susceptibility of nerve fiber to glaucomatous damage. When the optic disc was tilted or cyclotorted, inferior retinal nerve fiber layer was more easily affected than the superior one. Small size of the disc correlated significantly with multiple retinal nerve fiber layer defect (ref. 3), and large size of the disc correlated significantly with vulnerable papillo-macular bundle defect (ref. 4). On the other hand, presence of intrapapillary vessels (especially presence of retinal artery)correlated significantly with preservation of nerve fibers against glaucomatous nerve loss (ref. 2).
Assessment of the nerve fiber loss may be difficult by conventional photographs or ophthalmoscope. Thus, we conducted studies about new methodology usmng 3-dimensional image analysis (ref. 1), and Scanning Laser Ophthalmoscope (ref. 5, 6). These methodologies were better in assessing or understanding the glaucomatous nerve fiber loss in clinical practice. In conclusion, macroscopic variation of the optic disc is an important parameter which affect vulnerability of nerve fiber to glaucomatous damage. A new methodology is of value in assessing the degree of glaucomatous nerve damage in clinical practice.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Chihara E,Honda Y: "Topographic changes of the optic disc in eyes with cotton wool spot and primary open angle glaucoma." Graefes Arch Clin Exp.Ophthalmol. 229. 13-18 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E,Honda Y: "Preservation of nerve fiber layer by retinal vessels in glaucoma." Ophthalmology. 99. 208-214 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E,Honda Y: "Multiple retinal nerve fiber layer oufects in glaucoma." Graefes Arch Clin Exp.Ophthalmol. 230. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E,Tanihara H: "Papillo-maculan bundle aufects in normal tension glaucoma and high tension glaucoma." Graefes Arch Clin Exp.Ophthalmol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E,Chihara K: "Opparent cleavage of the retinal nerve fiber layer in normal eyes with high myopia" Graefes Arch Clin Exp.Ophthalmol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E,Takahash F,Chihara K: "Assessment of optic disc-topography with Scanniry Laser Ophthalmoscope" Graefes Arch Clin Exp.Ophthalmol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 千原 悦夫: "ベッドサイド眼科学「視野」" 南江堂,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 千原 悦夫: "レ-ザ-スキャン眼底カメラ" 文光堂,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E, Honda Y: "Topographic changes of the optic disc in eyes with cotton wool spot and primary open angle glaucoma." Graefes Arch Clin Exp Ophthalmol.229. 13-18 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E, Honda Y: "Preservation of nerve fiber layer by trinal vessels in glaucoma." Ophthalmology. 99. 208-214 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E, Honda Y: "Multiple retinal nerve fiber layer defects in glaucoma." Graefes Arch Clin Exp Ophthalmol.230. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E, Tanihara H: "Papillo-macular bundle defects in normal tension glaucoma and high tension glaucoma." Graefes Arch Clin Exp Ophthalmol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E, Chihara K: "Apparent cleavage of retinal nerve fiber layer in normal eyes with high myopia." Graefes Arch Clin Exp Ophthalmol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E, Takahashi F, Chihara K: "Assessment of optic disc topography with Scanning Laser Ophthalmoscope." Graefes Arch Clin Exp Ophthalmol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E: "Bedside Ophthalmology" "The visual field".Nankodo.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E.: "Scanning laser Ophthalmoscope." Bunkodo.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chihara E,Honda Y: "Topographic changes of the optic diss in eyes with cotton wool spot and primary open angle geaucoma." Graefes Arch.Clin.Exp.Qphthalmol.229. 13-18 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Chihara E.Honda Y: "Preservation of nerve fiker eayer by retinal vesses in glaucoma." Ophthaemology. 99. 208-214 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Chihara E,Honda Y: "Muetipes retinal nerve fiker eayer aufects in glaucoma." Graefes Arch.Clin.Exp.Opathaemol.230. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Chihara E,Tanihara H.: "Papilloーmacuear fundle aufects in normal tenscon glaucoma ana high tenscon glaucoma." Graefes Arch.Clin.Exp.Ophthalmol.

    • Related Report
      1991 Annual Research Report
  • [Publications] Chihara E,Chihara K.: "Apparent cleavage of the rctinal nerve fiher eayer in normal eyes with high myopia." Graefes Arch.Clin.Exp.Ophthalmol.

    • Related Report
      1991 Annual Research Report
  • [Publications] Chihara E,Takahashi F,Chihara K.: "Assessment of optic dise topography with Scanning Laser Ophthalmoscope." Graefes Arch.Clin.Exp.Ophthalmol.

    • Related Report
      1991 Annual Research Report
  • [Publications] 千原 悦夫: "ベッドサイド眼科学「視野」" 南江堂,

    • Related Report
      1991 Annual Research Report
  • [Publications] 千原 悦夫: "レ-ザ-スキャン眼底カメラ" 文光堂,

    • Related Report
      1991 Annual Research Report
  • [Publications] 千原 悦夫,他: "Atypical nerve fiber layer defects in myopic eys with high tension glaucoma." Arch.Ophthalmal.108. 228-232 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 千原 悦夫,他: "Topographic Changes of the optic disc in eyes with cotton wool spot and primary open angle glaucoma." Graefe's Arch.Clin Exp Ophthalmal. 229. 13-18 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山下 秀一,千原 悦夫,他: "Characterization of magnesium oupindent adenisine 5'ーtriphosphatase in bovine boain cytoplasmc dynein." Biochim.lnlernational.

    • Related Report
      1990 Annual Research Report
  • [Publications] 山下 秀一,千原 悦夫,他: "Characterization of the steaoyーstate Mg^<2+>ーdependent adenesine 5'ーtriphosphaーtaso of bovine brain Kinesin in the absene of microtubulus." J.Clinical Biochem.Nutritcor.

    • Related Report
      1990 Annual Research Report
  • [Publications] 千原 悦夫,他: "KrupinーDenver long eye shunt手術後慢性に高度の脈絡膜下血腫に進展した血管新生緑内障の1例" 日本眼科紀要. 41. 540-544 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 千原 悦夫,他: "閉塞隅角緑内障に対する虹彩切除後のSecondary plateau iris syndroneについて" 臨床眼科. 44. 831-834 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 澤田 惇,本田 孔士,千原 悦夫: "眼科臨床メモ" 南江堂, 309 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 東 郁郎編: "緑内障の薬物療法" ミクス, 203 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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