| Project/Area Number |
02454407
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kitasato University |
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Principal Investigator |
MIYATA Mikio 北里大学, 医学部, 教授 (30050438)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKU Hidehiro 北里大学, 医学部, 助手 (90177163)
FUKUSHIMA Kazuya 北里大学, 医学部, 助手 (60199205)
HORIUCHI Koushi 北里大学, 医学部, 助手 (80190239)
NAMBA Tatsuto 北里大学, 医学部, 講師 (70164514)
|
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| Project Period (FY) |
1990 – 1992
|
| Project Status |
Completed (Fiscal Year 1992)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1990: ¥1,900,000 (Direct Cost: ¥1,900,000)
|
|---|
| Keywords | Allergic conjunctivitis / Environment / Organophosphorous pesticide / p-Dichlorobenzene / Trihalomethane / Organochlorine herbicide / Food additives / Electromagnetic wave / パラジクロロベンゼン / トリハロメタン / 食品色素 / クロロホルム / 電磁波 / 環境汚染物質 / 防虫剤 / 有機燐殺虫剤 / 有機塩素除草剤 / 食品保存剤 / 有機リン殺虫剤 / アレルギ-性結膜炎 / タバコ煙 |
|---|
| Research Abstract |
In the recent years, the number of pollen induced allergic patients have increased. The reason for this could not be explained only by the increasing amount of cedar pollen antigen. Some environmental factors might cause the increase of disease. The present project was conducted to elucidate the factors.
The allergic conjunctivitis experimentally induced by cedar pollen was apparently aggravated by extremely low concentration of organophosphorous pesticides, organochlorine herbicide, cigarette smoke, trihalomethane, p-dichlorobenzene, food preservatives and food colors such as red No.3 and turtoladin. The aggravating effects of these chemicals were rather weak in higher concentration. Exposure to cathode ray tube of visual detector terminal also aggravated the allergic conjunctivitis. Environmental chemicals as well as electromagnetic waves seemed to derange our immunological condition.
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