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Laser photocoagulation treatment for choroidal neovascularization, experimental study

Research Project

Project/Area Number 02454412
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKansai Medical University

Principal Investigator

UYAMA Masanobu  Kansai Medical University, Department of Ophthalmology, Professor, 医学部, 教授 (30025580)

Co-Investigator(Kenkyū-buntansha) KISHIMOTO Naoko  Kansai Medical University, Department of Ophthalmology, Assistant, 医学部, 助手 (10194838)
TAKAHASHI Kanji  Kansai Medical University, Department of Ophthalmology, Assistant, 医学部, 助手 (60216710)
YAMAGISHI Kazuya  Kansai Medical University, Department of Ophthalmology, Instructor, 医学部, 講師 (90174599)
NISHIMURA Tetsuya  Kansai Medical University, Department of Ophthalmology, Instructor, 医学部, 講師 (30156111)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥5,900,000 (Direct Cost: ¥5,900,000)
KeywordsChoroidal neovascularization / Senile disciform macular degeneration / Subretinal neovascularization / Age-related macular degeneration / Laser-photocoagulation / Dye-laser / Retinal disease / Retinal Pigment epithelium / 網膜光凝固 / 新生血管黄斑症
Research Abstract

Senile disciform macular degeneration is now a leading cause of blindness in the elderly people. The disease arises from choroidal neovascularization (ChNV), for which laser photocoagulation (PC) is only a expectable treatment. We produced ChNV experimentally in the monkey retinas with krypton laser PC. Laser PC treatments were attempted for these experimentally produced ChNV in the monkey eyes, to determine the most effective reannual in laser PC treatment.
Among lasers, argon laser, and dye laser (wavelengths of 577, 590, 830 nm) were applied with weak or intense PC for ChNV nets which were revealed with fluorescein angiography. After PC, fundi were checked clinically and histapathologically for 3 months.
With weak or insufficient PC, newly formed vessele had remained in the subretinal space and the lesion did not healed. With intense or complete PC, ChNV were obliterated and disappeared at the lesion, and the lesion become scarring to heal. Argon laser PC was insufficient and damaged to the inner retina. Dye lasers of 577 and 590 nm were most effective to occlude ChNV.
These results showed that Iriser photocoagulation treatment for choroidal neovascularization, dye laser of 577 and 590 nm are most effective, and intense and complete coagulation covering the entire area of neovascular membrane is necessary to occlude the new vessel beneath the retina. These results indicate a significant information in clinical reannual.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 宇山 昌延: "脈絡膜新生血管、基礎と臨床(第95回日本眼科学会総会特別講演)" 日本眼科学会雑誌. 95. 1145-1180 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 高橋 寛二: "実験的網膜下新生血管に対する色素レ-ザ-による光凝固治療1.光凝固による治癒過程の組織学的検索" 日本眼科学会雑誌. 94. 799-809 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 高橋 寛二: "実験目網膜下新生血管に対する色素レ-ザ-による光凝固治療2.光凝固の奏効しなかった病巣の組織学的検索" 日本眼科学会雑誌. 94. 810-819 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 山田 佳苗: "実験的脈絡膜新生血管に対するレ-ザ-光凝固 第1報:弱度凝固による新生血管の凝固効果" 日本眼科学会雑誌. 96. 169-179 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masanobu Uyama: "Choroidal Neovascularization, Experimental and Clinical Study" Acta Soc Ophthalmol Jpn 95. 1145-1180 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kanji Takahashi, Takashi itagaki, Kazuya Yamagishi, Hiroshi Ohkuma, Tetsuya Nishimura and Masanobu Uyama: "Dye Laser Photocoagulation Treatment for Experimental Subretinal Neovascularization 1. Histopathological Findings of Healing Process" Acta Soc ophthalmol Jpn 94. 799-809 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kanji Takahashi, Takashi itagaki, Kazuya Yamagishi, Hiroshi Ohkuma, Tetsuya Nishimura and Masanobu Uyama: "Dye Laser Photocoagulation Treatment for Experimental Subretinal Neovascularization 2. Histopathological Findings of Unsuccess Lesions" Acta Soc Ophthalmol Jpn 94. 810-819 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kanae Yamada, Kanji Takahashi, Hiroshi Ohkuma, Takashi Itagaki, Tetsuya Nishimura, Yamagishi Kazuya, Takako Tomoda, and Masanobu Uyama: "Laser Photocoagulation for Experimental Choroidal Neovascularization 1. Mild Dye Laser Photocoagulation" Acta Soc Ophthalmol Jpn 95. 1145-1180 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 宇山 昌延: "脈絡膜新生血管、基礎と臨床(第95回日本眼科学会総会 特別講演)" 日本眼科学会雑誌. 95. 1145-1180 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 高橋 寛二: "実験的網膜下新生血管に対する色素レ-ザ-による光凝固治療 1.光凝固による治癒過程の組織学的検索" 日本眼科学会雑誌. 94. 799-809 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 高橋 寛二: "実験的網膜下新生血管に対する色素レ-ザ-による光凝固治療 2.光凝固の奏効しなかった病巣の組織学的検索" 日本眼科学会雑誌. 94. 810-819 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 山田 佳苗: "実験的脈絡膜新生血管に対するレ-ザ-光凝固 第1報:弱度凝固による新生血管の凝固効果" 日本眼科学会雑誌. 96. 169-179 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 高橋 寛二: "実験的網膜下新生血管に対する色素レ-ザ-による光凝固治療 1.光凝固による治癒過程の組織学的検索" 日本眼科学会雑誌. 94. 799-809 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 高橋 寛二: "実験的網膜下新生血管に対する色素レ-ザ-による光凝固治療 2.光凝固の奏効しなかった病巣の組織学的検索" 日本眼科学会雑誌. 94. 810-819 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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