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Pathology of aural cholesteatoma and the prevention of its recurrence

Research Project

Project/Area Number 02670759
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionNiigata University

Principal Investigator

NAKANO Yuichi  Niigata University School of Medicine, Professor, 医学部, 教授 (80018316)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Sugata  Niigata University School of Medicine, Senior lecturer, 医学部附属病院, 講師 (10154824)
佐藤 弥生  新潟大学, 医学部附属病院, 助手 (80196279)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
KeywordsCholesteatoma / Mastoid Air Cells / Eustachian Tube Function / Tympanoplasty / Mastoid Obliteration / Hydroxyapatite / Recurrent Cholesteatoma / Secretory Otitis Media
Research Abstract

In general, development of the mastoid air cell system is inhibited in ears with chronic inflammatory diseases including cholesteatoma, chronic otitis media and secretory otitis media. X-ray studies revealed that aquired cholesteatomas showed the most inhibited mastoid among them. Secretory otitis media which developed cholesteatoma subsequently had smaller mastoid in secretory otitis media group, significantly. Experimental studies demonstrated that tubal occlusion of pigs just after the birth induced under-developed mastoid air cells. In conclusion, aquired cholesteatomas might have poor middle ear ventilation function of the eustachian tube during the period of mastoid growth and after its built up.
Tympanoplasty with mastoid obliteration using hydroxyapatite granules was conducted. A small middle ear cavity was established to compensate the eustachian tube dysfunction. Biocompatibility and bone adaptability of the hydroxyapatite granules as a material of mastoid obliteration were confirmed by an experimental study in the temporal bullae of guinea pigs. This technique showed excellent postoperative results without recurrence of cholesteatoma. The outcome of the postoperative hearing acuity is similar to other techniques.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] NAKANO,Yuichi: "Prognosis of otitis media with effusion in children and size of the mastoid air symtem" Acta Otolaryngol. Suppl. 56-61 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 高橋 姿: "セラミックス顆粒塊による乳突充填法の検討-実験的研究-" Ear Researd Japan. 21. 11-12 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SATO,Yayoi: "Suppressed mastoid neumatization in cholesteatoma" Acta Otolaryngol. Suppl471. 62-65 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 高橋 姿: "ハイドロキシアパタイト顆粒塊を用いた乳突充填鼓室形成術-臨床的ならびに実験的研究-" 日本耳鼻科咽喉科学会会報. 94. 833-842 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] IKARASHI,F: "Relation between the number of incidents of inflammation and penumatization" Otolaryngology Head NeckSurg.Proceedings of the XIV World Congress,KUGLER & GHEDINI. 581-585 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] TAKAHASHI,Sugata: "Tympanoplasty with mastoid obliteration using hydroxyapatite granules" Transplants and Implants in Pctology II,KUGLER & GHEDINI. 159-163 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakano Y,: "Prognosis of otitis media with effusion in children and size of the mastoid air system" Acta Otolaryngol Suppl. 471. 56-61 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahashi S: "Obliteration of temporal dorsal bullae using hydroxyapatite granules -an experimental study-" Eae Res Jpn. 21. 11-12 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sato Y: "Suppressed mastoid pneumatization in cholesteatoma" Acta Otolaryngol Suppl. 471. 62-65 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahashi S: "Tympanoplasty with mastoid obliteration using hydroxyapatite granules for aural cholesteatoma - a clinical and experimental study -" J Otolaryngol Jpn. 94. 833-842 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ikarashi F: "Relation between the number of incidents of inflammation and pneumatization" Otolaryngol Head Neck Surg. Proceedings of the XIV World Congress, KUGLER & GHEDINI.581-585 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahashi S: "Tympanoplasty with mastoid obliteration using hydroxyapatite granules" Transplants and Implants in Otology II, KUGLER & GHEDINI.159-163 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 高橋 姿: "ハイドロキシアパタイト顆粒塊を用いた乳突充填鼓室形成術ー臨床的ならびに実験的研究ー" 日本耳鼻咽喉科学会会報. 94. 833-842 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takahashi, Sugata: "Tympanoplasty with mastoid obliteration using hydroxyapatite granules" Transplants and Implants in Otology II,KUGLER & GHEDINI. 159-163 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 高橋 姿: "ハイドロキシアパタイト顆粒塊を用いた乳突充填鼓室形成術ー臨床的ならびに実験的研究ー" 日本耳鼻咽喉科学会会報. 94. 833-842 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sugata Takanashi: "Tympanoplasty with mastoid obliteration by means of hydroxyapatite granules for aural choiesteatoma" Otolaryngol Head Neck Surg.Proceedings of the XIV World Congress,KUGLER & GHEDINI. 419-421 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yayoi Sato: "Suppressed mastoid pneumatization in cholesteatoma" Otolaryngol Head Neck Surg.Proceedings of the XIV World Congress,KUGLER & GHEDINI. 509-510 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Fumio Ikarashi: "Relation betweenthe number of incidents of inflammation and pneumatization" Otolaryngol Head Neck Surg.Proceedings of the XIV World Congress,KUGLER & GHEDINI. 581-585 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 高橋 姿: "中耳手術におけるヒト濃縮フィブリン接着剤Tisseelの有用性" 耳鼻咽喉科展望. 34補1. 101-106 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 中野 雄一: "真珠腫" 金原出版 耳鼻咽喉科頭頚部外科MOOK. No.16. 231 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yuichi Nakano: "Prognosis of otitis media with effusion in children and size of the mastoid air system" Acta Otolaryngol Suppl. 471. 56-61 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 高橋 姿: "セラミック顆粒塊による乳突充填法の検討ー実験的研究ー" Ear Res Jpn. 21. 11-12 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yayoi Sato: "Suppressed Mastoid Pneumatization in cholesteatoma" Acta Otolaryngol Suppl. 471. 62-65 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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