Pathology of aural cholesteatoma and the prevention of its recurrence
| Project/Area Number | 02670759 |
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Niigata University |
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Principal Investigator |
NAKANO Yuichi Niigata University School of Medicine, Professor, 医学部, 教授 (80018316)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Sugata Niigata University School of Medicine, Senior lecturer, 医学部附属病院, 講師 (10154824)
佐藤 弥生 新潟大学, 医学部附属病院, 助手 (80196279)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed(Fiscal Year 1992)
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| Budget Amount *help |
¥2,300,000 (Direct Cost : ¥2,300,000)
Fiscal Year 1992 : ¥800,000 (Direct Cost : ¥800,000)
Fiscal Year 1991 : ¥900,000 (Direct Cost : ¥900,000)
Fiscal Year 1990 : ¥600,000 (Direct Cost : ¥600,000)
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| Keywords | Cholesteatoma / Mastoid Air Cells / Eustachian Tube Function / Tympanoplasty / Mastoid Obliteration / Hydroxyapatite / Recurrent Cholesteatoma / Secretory Otitis Media |
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| Research Abstract |
In general, development of the mastoid air cell system is inhibited in ears with chronic inflammatory diseases including cholesteatoma, chronic otitis media and secretory otitis media. X-ray studies revealed that aquired cholesteatomas showed the most inhibited mastoid among them. Secretory otitis media which developed cholesteatoma subsequently had smaller mastoid in secretory otitis media group, significantly. Experimental studies demonstrated that tubal occlusion of pigs just after the birth induced under-developed mastoid air cells. In conclusion, aquired cholesteatomas might have poor middle ear ventilation function of the eustachian tube during the period of mastoid growth and after its built up.
Tympanoplasty with mastoid obliteration using hydroxyapatite granules was conducted. A small middle ear cavity was established to compensate the eustachian tube dysfunction. Biocompatibility and bone adaptability of the hydroxyapatite granules as a material of mastoid obliteration were confirmed by an experimental study in the temporal bullae of guinea pigs. This technique showed excellent postoperative results without recurrence of cholesteatoma. The outcome of the postoperative hearing acuity is similar to other techniques.
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Report
(4results)
Research Products
(23results)
