| Project/Area Number |
02671005
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka |
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Principal Investigator |
NAKAYAMA Koichi Professor and Head Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, 薬学部, 教授 (50112769)
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| Co-Investigator(Kenkyū-buntansha) |
田中 芳夫 静岡県立大学, 薬学部, 助手 (60188349)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1991: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1990: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Mechano-sensor / Calcium signaling / Calcium channel / Phospholipase C / Vascular tissue / Alpha-toxin / inositol 1, 4, 5 trisphosphate / Vasodilator / 脳血管 / 筋原性収縮 / 急速伸展刺激 / 物理受容・応答 / Ca^<2+>チャネル / Gー蛋白 / ホスホリパ-ゼC / ライアノジン |
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| Research Abstract |
The vascular system is a site of not only chemical but also mechanical reception, and these stimuli elicit subsequent cellular responses such as contraction and relaxation. The vascular tissues such as cerebral and coronary arteries and lymphaticus, which are particularly sensitive to stretch, possess structural similarities ; lowpitched muscular lining, well-developed caveola beneath the plasma membrane, and abundant mitochondria. The mechanical reception is more susceptible than pharmacological reception to chemical skinning, suggesting the importance of membrane lipids as a mechanosensor domain. Phospholipase C coupled to GTP-binding protein, possibly a G_q class, which is insensitive to cholera- or pertussis toxin, may play a role in the genesis of vascular tone produced by quick stretch. The vascular reactivity to a mechanical stimulus may be mediated through the pathways of Ca^<2+> signaling which are specific to the mechano-reception and common to a conventional vasoconstrictive agonist such as norepinephrine.
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