| Project/Area Number |
02808020
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
体育学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
HOSOKAWA Jun-ichi Univ. of Tsukuba, Health and sport science, Prof., 体育科学系, 教授 (40015714)
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| Co-Investigator(Kenkyū-buntansha) |
TAGAMI Kazumi Univ. of Tsukuba, Health and sport sci., Assist prof, 体育科学系, 講師 (40171566)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1992: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 1991: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Cytotoxicity / Natural killer cell / Exersize / Training / Swimming / Rat / 細胞性免疫能 / ナチュラル・キラー細胞 / 運動中止 / 糖代謝 / 脂肪代謝 / T細胞幼若化能 / マクロファ-ジ貧食能 / LAK細胞活性 / コレステロ-ル / 耐糖能 |
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| Research Abstract |
We have studied a post-retirement effect of long time hard training of elite sport person on immune functions. Immunologic merit by the exercise training are controversial. We proposed here one new approach to know the benefit of exercise on natural killer (NK) cell activity.
The trained rats were offered 30 min warm water swimming, 4 times in a week, while the sedentary control animals exposed to warm shallow water same manner as the trained ones. These were tested their splenic NK cell activity against human lymphoma, K-562 cells. Half of both groups of rats were intra-peritonialy administered 50 mg/kg of Cyclosporin A, the immuno-suppressive agent, and the rest were administered same volume of vehicle (saline) 24 hours before NK testing.
No difference of the NK activity was observed between the trained and the sedentary animals without immuno-suppressive agent. The trained animals with immuno-suppression presented significantly higher (P < 0.05) NK cell activity (23.1 * 2.4 %) than the sedentary ones (14.4 * 5.0 %).
Our index had strict relation between exercise and NK cell activity. Thus, the increased resistance to the agent will cross react with the behavioral immuno-suppressors such as stressful environment exposure.
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