大腸がん発症における食生活要因と遺伝子要因の交互作用に関する研究

• Project/Area Number: 02J61466
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: Public health/Health science
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: 栗木 清典 愛知県がんセンター(研究所), 疫学・予防部, 特別研究員PD
• Project Period (FY): 2002 – 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥3,600,000 (Direct Cost: ¥3,600,000); Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000); Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000); Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 大腸がん / インスリン抵抗性 / 糖尿病 / PPARγ / 遺伝子多型 / 脂肪酸 / バイオマーカー / 特許 / がん予防 / 症例・対照研究 / 食生活習慣 / 獣肉摂取 / 日本人 / CD36 / ALDH2

Research Abstract

大腸がんの罹患リスクに対する獣肉摂取と、インスリン抵抗性に関連するPPARγ遺伝子Ala12Pro多型、C161T多型およびCD36遺伝子A52C多型の相互作用を明らかにする症例・対照研究を実施した。Pro12Ala多型とC161T多型を組み合わせた解析において、全体の70.0%を占めるPro/Pro + C/Cでは、牛乳、卵の低摂取頻度に対する高摂取頻度のオッズ比(OR)は0.82、0.78と低かったが、Pro/Pro + (C/T+T/T)(25.3%)の飽和脂肪酸、加工肉摂取では1.42、1.63と高かった。CD36遺伝子において、A/A型の牛・豚肉の低頻度摂取、獣肉の低摂取量と比較して、C/C型の高摂取によるORは4.39、3.16と高かった。
現在、わが国の40歳以上の10人に1人が糖尿病を患っており、糖尿病は一部のがんのリスク要因と報告されているが、日本人におけるリスク評価は十分ではない。そこで、糖尿病と臓器別がんリスクを大規模症例・対照研究で検討した。糖尿病の現病・既往のある男は7.5%、女は2.6%であった。糖尿病のORは、男/女の全部位(1.4/1.4)、肺(1.5/1.6)と肝臓(2.2/2.3)、男の咽頭(1.8)、喉頭(2.3)、食道(1.7)、膵臓(2.3)と大腸(1.3)、胃(1.7)と子宮頚部(1.9)で有意に高かったことから、糖尿病を引き起こすインスリン抵抗性はがんのリスク要因でもあるという仮説を支持した。
近年の生活習慣の急速な欧米化に伴い増加している疾病のリスクを評価し、個人を対象にした一次予防方法を確立するには、食生活習慣調査とともに、脂質・脂肪酸摂取のバイオマーカーを確立することが必要である。そこで、多数の血液検体から、微量で、迅速、簡便、安価、高精度に脂肪酸レベルを分析する独自の方法を開発し、特許出願した。

Research Products

• [Journal Article] Increased risk of colorectal cancer due to the interaction between meat consumption and the CD36 gene A52C polymorphism among Japanese (2005)
  • Author(s): Kiyonori Kuriki, et al.
  • Journal Title: Nuts Cancer 51(2) Pages: 170-177
• [Journal Article] Relation of the CD36 gene A52C polymorphisms to the risk of colorectal cancer among Japanese, with reference to gene-gene and -environmental interactions with the aldehyde dehydrogenase 2 and alcohol consumption (2005)
  • Author(s): Kiyonori Kuriki, et al.
  • Journal Title: Asian Pac J Cancer Prev 6(1) Pages: 62-68
• [Journal Article] Association between type II diabetes and colon cancer among Japanese with reference to changes in food intake (2004)
  • Author(s): Kiyonori Kuriki, et al.
  • Journal Title: Asian Pac J Cancer Prev 5(1) Pages: 28-35
• [Journal Article] Anthropometric, lifestyle and hiomarker assessment of Japanese non-professional Ultra-marathon runners (2004)
  • Author(s): Shinkan Tokudome, et al.
  • Journal Title: J Epidemiol 14(5) Pages: 161-167
• [Journal Article] An epidemiological study of HBV, HCV and HTLI-I in Sherpas of Nepal (2004)
  • Author(s): Hitoshi Chiba, et al.
  • Journal Title: Asian Pac J Cancer Prev 5(4) Pages: 370-373
• [Journal Article] Letter to editor : Helicobacter pylori infection and gastric cancer : facing the enigmas (2004)
  • Author(s): Shinkan Tokudome, et al.
  • Journal Title: Int J Cancer 112(1) Pages: 166-167
• [Journal Article] Letter to editor : The Mediterranean vs the Japanese diet. (2004)
  • Author(s): Shinkan Tokudome, et al.
  • Journal Title: Eur J Clin Nutr 58(9) Pages: 1323-1323
• [Journal Article] 糖尿病による臓器別がんのリスク (2004)
  • Author(s): 栗木清典, 田島和雄
  • Journal Title: 食の科学 No.325 Pages: 14-20
• [Journal Article] Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia (2003)
  • Author(s): Shinkan Tokudome, et al.
  • Journal Title: Cancer Lett 219(1) Pages: 57-61
• [Patent(Industrial Property Rights)] 脂肪酸の測定のための方法およびシステム (2005)
  • Inventor(s): 田島 和雄, 栗木 清典
  • Industrial Property Rights Holder: 愛知県病院事業長, 外山 淳治
  • Industrial Property Number: 2005-080461
  • Filing Date: 2005-03-18
• [Publications] Kiyonori Kuriki: "Plasma concentrations of (n-3) highly unsaturated fatty acids are good biomarkers of relative dietary fatty acid intakes : a cross-sectional study"J.Nutr.. 133(11). 3643-3650 (2003)
• [Publications] Kiyonori Kuriki: "Association between type II diabetes and colon cancer among Japanese with reference to changes in food intake"Asian Pac.J.Cancer Prev.. (In press). (2004)
• [Publications] Shinkan Tokudome: "Correspondence : n-6 Polyunsaturated fatty acids and breast cancer"Nutr.Cancer. (In press). (2004)
• [Publications] Shinkan Tokudome: "Correspondence : The Mediterranean vs the Japanese diet"Eur J.Clin.Nutr.. (In press). (2004)
• [Publications] Wang J.: "Association of GSTM1,CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma : a case-control study in Chinese population"Cancer Sci.. 94(5). 448-452 (2003)
• [Publications] Yuko Tokudome: "Seasonal variation in consumption and plasma concentrations of fatty acids in Japanese female dietitians"Eur J Epidemiol.. 18(10). 945-953 (2003)
• [Publications] Kiyonori Kuriki: "Plasma concentrations of (n-3) highly unsaturated fatty acids are good biomarkers of relative dietary fatty acid intakes : a cross-sectional study"J.Nutr.. 133(11). 3643-3650 (2003)
• [Publications] Kiyonori Kuriki: "Association between type II diabetes and colon cancer among Japanese with reference to changes in food intake"Asian Pac.J.Cancer Prev.. (In press). (2004)
• [Publications] Shinkan Tokudome: "Correspondence : n-6 Polyunsaturated fatty acids and breast cancer"Nutr.Cancer. (In press). (2004)
• [Publications] Shinkan Tokudome: "Correspondence : The Mediterranean vs the Japanese diet"Eur J.Clin.Nutr.. (In press). (2004)
• [Publications] Wang J.: "Association of GSTM1,CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma : a case-control study in Chinese population"Cancer Sci.. 94(5). 448-452 (2003)
• [Publications] Yuko Tokudome: "Seasonal variation in consumption and plasma concentrations of fatty acids in Japanese female dietitians"Eur J Epidemiol.. 18(10). 945-953 (2003)
• [Publications] Kiyonori Kuriki: "Nippon Rinsho"Epidemiology of colorectal cancer among Japanese. 6 (2003)
• [Publications] Kiyonori Kuriki: "Nippon Rinsho"Epidemiology of colorectal cancer among Japanese. 6 (2003)
• [Publications] Kuriki Kiyonori: "Discrepancies in dietary intakes and plasma concentrations of fatty acids according to age among Japanese female dietitians"Eur. J. Clin. Nutr.. 56(6). 524-531 (2002)
• [Publications] Tokudome Yuko: "Daily, weekly, seasonal, within-and between-individual variation in nutrient intake according to four season consecutive 7 day weighed diet records in Japanese female dietitians"J. Epidemiol.. 12(2). 85-92 (2002)
• [Publications] Imaeda Nahomi: "Reproducibility of a semi-quantitative food frequency questionnaire in Japanese female dietitians"J. Epidemiol.. 12(1). 45-53 (2002)
• [Publications] Hayashi kimiko: "Associations between physical strength, cerebral function and mental health in independent-living elderly Japanese women"Environ. Health Prey. Med.. 7(3). 123-128 (2002)
• [Publications] Tokudome Shinkan: "Rationale and study design of dietary intervention in patients polypectomized for tumors of the colorectum"Jpn. J. Clin. Oncol.. 32(12). 550-553 (2002)
• [Publications] Tokudome Shinkan: "Correspondence re : Terry et al., No association between fat and fatty acids intake and risk of colorectal cancer. Cancer Epidemiol. Biomark. Prey., 10: 913-914, 2001"Cancer Epidemiol Biomark. Prev.. 11(2). 217-218 (2002)
• [Publications] Cheng, JL.: "Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors"Cancer letter. (in press).
• [Publications] Tokudome Yuko: "Seasonal variation in consumption and plasma concentrations of fatty acids in Japanese female dietitians"Eur. J. Epidemiol.. (in press).