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Promotion of regeneration of remnant pancreas after pancreatectomy and modification of pylorus-preserving procedure

Research Project

Project/Area Number 03454322
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionYamaguchi University

Principal Investigator

SUZUKI Takashi  Yamaguchi University, Facutly of Medicine, Professor, 医学部, 教授 (20026834)

Co-Investigator(Kenkyū-buntansha) KAN Seikon  Yamaguchi University, Facutly of Medicine, Lecturer, 医学部附属病院, 助手 (00234146)
TANGOKU Akira  Yamaguchi University, Facutly of Medicine, Lecturer, 医学部, 助手 (10197593)
HAMANAKA Yuichiro  Yamaguchi University, Facutly of Medicine, Associate Professor, 医学部附属病院, 講師 (40189618)
OKA Masaaki  Yamaguchi University, Facutly of Medicine, Associate Professor, 医学部, 助教授 (70144946)
内山 哲史  山口大学, 医学部, 助手 (90136177)
村上 卓夫  山口大学, 医学部, 助教授 (10091216)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1991: ¥3,400,000 (Direct Cost: ¥3,400,000)
KeywordsPancratoduodenectomy / Gastropancreatic interaction / Major pancreatectomy / Pancreattic regeneration / Pancreatic function / Gastrectomy / Gut hormones / Nutrition / 膵外分泌機能 / インスリン分泌 / 消化管ホルモン分泌 / 酸分必 / 酸分泌
Research Abstract

1.Experimental studies 1).The effect of preserving the total stomach on endocrine pancreatic function after major pancreatectomy was imvestigated. The animals were divided into those with major pancreatectomy alone and those with pancreatectomy plus gastrectomy. In the latter, glucose tolerance and insulin release were more impa ; ired, suggesting that preservation of the total stomach is effective for saving the impaired pancreatic function after pancreatectomy.
2).The effect of oral administration of trypsin inhibitor on the above-mentioned pancreatic dysfunction was observed. By means of trypsin inhibitor, a significant increase in the tissue weight was demonstrated in the remnant pancreas and the impaired glucose tolerance tended to be improved.
3).The animals, in which the stomach and the duodenum were removed en bloc, showed decrease in pancreatic weight pancreatic DNA, RNA and protein contents. Pentagastrin ameliorated such pancreatic atrophy to similar degree to the control group … More , indicatying that endogenous gastrin is an important regulator of the pancreas.
2.Clinical studies 1).Plasma gastrin and CCK responses were measured after a pancreatoduodenectomy using Billroth-I type reconstruction combined with distal partial gastrectomy(standard PD) and combined with presevation of the pylorus and the duodenal bulb.(PPPD). Basal and postprandial levels of gastrin after PPPD was similar in pattern to that found in controls. Basal plasma levels of CCK in the patients after standard PD were significantly lower than in controls, and significant higher postprandial levels of CCK were found after PPPD compared to standard PD.These results suggest that presevation of the stomach and the duodenal bulb in pancreatectomy has more beneficial effect on the duodenal bulb in pancreatectomy has more and CCK are known to have a trophic effect on the pancreas.
2).The follow-up study showed that nutritional conditions in the patients treated by PPPD were better than those by standard PD. Less

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] Inoue K,Suzuki T et al: "Microcirculatory response of the pancreas to feeding,sham feeding,and truncal vagotomy in conscious dogs." Pancreas. 8. 28-33 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tangoku A et al: "Humoral factors that induce alterations of the pancreas in rats with obstructive jaundice." Pancreas. 8. 103-108 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tangoku A et al: "Exogenous administration of estradiol and cholecystokinin alters exocrine pancreatic function in rats." Int.J.Pancreatol.13. 81-86 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ueno T,Suzuki T et al: "Xanthogranulomatous change appearing in the pancreas cyst wall." Pancreas. 8. 649-651 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 浜中裕一郎、鈴木敞: "胃幽門輪温存術" 手術. 47. 169-174 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki T et al: "Pylorus-preserving pancreatoduodenectomy in Japan:history and present status." J.Hep.Bil.Panc.Surg.2(In press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki T et al: "Pitfall and Complications in the Diagnosisi and Management of Hepatobiliary and Pancreatic Diseases" Georg Thieme Verlag, 537 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 鈴木敞ほか: "消化器外科学" 朝倉書店, 495 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tangoku A, Suzuki T et al.: "Plasma gastrin and CCK response after pylorus preserving pancreatoduodenectomy with Billroth I type of reconstruction." Ann.Surg. 214. 56-60 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tangoku A et al.: "Estrpgens influence cholecystokinin stimulated pancreatic amylase release and acinar cell membrance cholecystokinin receptors in rats." Life Sci.48. 1565-1574 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shinagawa Y, Suzuki T: "Effect of total gastrectomy on remnant islet cell function after major pancreatectomy in rats." Pancreas. 7. 30-33 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Uchiyama T,Suzuki T et al.: "Pancreatic pleural effusion : case report and review of 113 cases in Japan." Am.J.Gastroent. 87. 387-391 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tangoku A et al.: "Simultaneous measurement of cholecyotokininstimulated amylase release and cholecystokinin receptor biding in at pancreatic acini." J.Lab.Clin.Med.119. 566-573 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tangoku A et al.: "Exocrine pancreatic function in obstructive jaundice rat : studied with isolated dispersed pancreatic acini." J.Surg.Res.53. 378-383 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Inoue K, Suzuki T et al.: "Microcirculatory response of the pancreas to feeding, sham feeding, and truncal vagotomy in conscious dogs." Pancreas. 8. 28-33 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tangoku A et al.: "Humoral factors that induce alterations of the pancreas in rats with obstructive jaundice." Pancreas. 8. 103-108 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tangoku A et al.: "Exogenous administration of estradiol and cholecystokinin alters exocrine pancreatic function in rats." Int.J.Pancreatol.13. 81-86 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki T et al.: "Pylorus-preserving pancreatoduodenectomy in Japan : history and present status." J.Hep.Bil.Panc.Surg.2. in press (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Inoue K,Suzuki T et al.: "Microcirculatory response of the pancreas to feeding,sham feeding,and truncal vagotomy in conscious dogs." Pancreas. 8. 28-33 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tangoku A et al.: "Humoral factors that induce alterations of the pancreas in rats with obstructive jaundice." Pancreas. 8. 103-108 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tangoku A et al.: "Exogenous administration of estradiol and cholecystokinin alters exocrine pancreatic function in rats." Int.J.Pancreatol.13. 81-86 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ueno T,Suzuki T et al.: "Xanthogranulomatous change appearing in the pancreas cyst wall." Pancreas. 8. 649-651 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 浜中裕一郎、鈴木敞: "胃幽門輪温存術" 手術. 47. 169-174 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Suzuki T et al.: "Pylorus-preserving pancreatoduodenectomy in Japan:history and present status. (In press)" J.Hep.Bil.Panc.Surg.2. (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Suzuki T et al.: "Pitfall and Complications in the Diagnosisi and Management of Hepatobiliary and Pancreatic Diseases" Georg Thieme Verlag, 537 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 鈴木敞 ほか: "消化器外科学" 朝倉書店, 495 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Uchiyama, T.: "Pancreatic pleural effusion : case report and review of 113 cases in Japan." Am. J. Gastroent.87. 387-391 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yano, K.: "The effect of temporary hepatic artery or portal vein occlusion on in obstructive jaundice." J. Surg. Res.53. 470-474 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 鈴木 敞: "慢性膵炎に対する手術術式の選択" 手術. 46. 1397-1403 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 丹黒 章: "消化管ホルモンんを介する膵頭十二指腸切除術後の消化吸収における胃十二指腸膵相関" 消化と吸収. 15. 41-47 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 浜中 裕一郎: "乳頭部癌に対する幽門輪温存膵頭十二指腸切除" Medical Practice. 9. 1602-1604 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 丹黒 章: "膵切除後の栄養管理" 胆と膵. 13. 381-386 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 鈴木 敞: "最新内科学大系:膵疾患1" 山村雄一ほか(中山書店), 438 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 鈴木 敞: "最新消化器外科シリーズ:膵臓(I)" 阿部令彦ほか(金原出版), 144 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 鈴木 敞: "幽門輪温存膵頭十二指腸切除ーその後の知見" 外科. 53. 1419-1428 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 鈴木 敞: "全胃幽門輪温存膵頭十二指腸切除術" 消化器外科. 14. 465-473 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 浜中 裕一郎: "脂肪消化吸収障害の新しい診断法と臨床的意義" JJPEN. 14. 3-8 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Shinagawa,Y.: "Effect of total Gastrectomy on remnant islet cell function after major pancreatectomy in rats." Pancreas. 7. 30-33 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tangoku,A.: "Plasma gastrin and CCK response after pylorus preserving pancreatoduodenectomy with Billroth I type of reconstruction." Ann.Surg.214. 56-60 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Nishida,M.: "Introduction of monoclonal antibodies to bromodeoxyuridine to monitor hepatic regeneration." Gastroenterology. 100. 1135-1137 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 鈴木 敞: "外科学" 阿部令彦ほか(朝倉書房), 674 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 鈴木 敞: "今日の消化器疾患治療方針" 多賀須幸男ほか(医学書院), 687 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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