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Trial of enhancement in lyngbatic organ activety during TPN using PSK

Research Project

Project/Area Number 03670643
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTokai Univ, School of medicine . Dept. Surg II

Principal Investigator

NAKASAKI Hisao (1992)  Tokai Univ. Surg II,associate Pro, 医学部外科2, 助教授 (10056145)

花上 仁 (1991)  東海大学, 医学部, 助教授 (40121446)

Co-Investigator(Kenkyū-buntansha) KUROSAWA Tsutomu  Ohsaka Univ. Experi. animal, associate Pro, 医学部実験動物, 助教授 (60129997)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsTPN / S-IgA / PSK / Bacterial Translocation / リンパ球サブセット / 消化管リンパ節 / BRM / 消化管廃用性萎縮 / 経中漢静脈高カロリ-輸液 / Biological Response Modifier / パイエル板 / helper / inducer T / suppressor / cytotoxic T
Research Abstract

In 1991, we made a study of the influence of the method of feeding by central venous catheter, and obtained the following results.
1)The method of feeding by central venous catheter causes the atrophy of the mucus of the digestive tract.
2)Dosage of PSK prevents the decrease of agmen peyerianum and also normalizes the internal distribution of immunological cells.
In 1992, we studied how the method of feeding by central venous catheter (in TPN group) affects the immunological system.
1)S-IgA in gall
2)S-IgA in portal venous blood
3)Bacterial translocation to mesenteric lymph nodes respectively studied.
Results
The bacteriological study of mesenteric lymph nodes revealed that bacteria were detected at a higher rate in TPN group compared with the control group
There was no difference in endotoxin concentration in portal venous blood.
Less S-IgA was detected in gall and portal venous blood in TPN group.
In the study of distribution of immunological cells in the mucus of digestive tract, the test result implied a fall in immunocompetence in TPN group.
Conclusion/review
The immunocompetence at digestive tract was lowered by using TPN for a long term. The dosage of BRM such as PSK is effective against these falls.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] H.Hanaue: "The effect of a protein-bound polysaccharide(PSK) on lymph cyte subsets in normal rat" Except Medica. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hitoshi Hanaue: "The effect of a protein-Bound polysaccaride on Tcell subsets of Deripheral Venous Blood and Thoracic Duet lymph" Tokai J.Exp Clin,Med. 16. 163-169 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 花上 仁: "経中心静脉高カロリー輸液がもたらす消化管付属リンパ組織の機能低下とその対策" 消化器と免疫. 27. 93-98 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hitoshi HANAUE,Akira OKUMURA,Kohsi KANNO,Tomoo TAJIMA and Toshio MITOMI: "The Effect of a ProteinーBound Polysaccharide on T Cell Subsets of Peripheral Venous Blood and Thoracic Duct Lymph" Tokai J Exp Clin Med. 16. 163-169 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 花上 仁,田島 知郎,三富 利夫: "経中心静脈高カロリ-輸液がもたらす消化管付属リンパ組織の機能低下と対策" 第27回消化器と免疫 研究会 プログラム・抄録. 4-4 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 花上 仁,田島 知郎,三富 利夫: "経中心静脈高カロリ-輸液がもたらす消化管付属リンパ組織の機能低下と対策" 消化器と免疫. 27. (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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