|Budget Amount *help
¥2,200,000 (Direct Cost : ¥2,200,000)
Fiscal Year 1992 : ¥200,000 (Direct Cost : ¥200,000)
Fiscal Year 1991 : ¥2,000,000 (Direct Cost : ¥2,000,000)
The effect of isoflurane on the increase in serum myoglobin (Mb) and creatinekinase (CK) levels induced by Sch was studied. 78 children were divided into four groups ; in the two groups (Group IV, IM), the induction and maintenance was achieved with N20, 02 and isoflurane, and in the last two groups (Group HV, HM) halothane was administered instead of isoflurane. After loss of consciousness, they were injected with Sch 1mg/kg intravenously in Group IV and IH, and 2mg/kg intramusculaly in Group IM and IH to facilitate tracheal intubation. Blood samples were drawn till 60 min. Mb was determined by the radioimmunoassay and CK was by the modified Rosalki's method. AS a result, Mb values increased from 5 min in all groups, and CK values increased from 5 min in Group IV and HV, and at 60 min in Group IM and HM. The value in Group IV at 60 min was 120 times higher than the control data in Mb, and 5 times in CK, respectively. The values in Group IM and HM were less than Group IV and HV, and th
e delays in increases were noted. There was not a significant difference in the values between Group IV and HV, or Group IM and HM. K^+ value increased remarkably in Group IM and HM till 20 min, and decreased in Group IV and HV at 60 min. Inorganic phosphate increased at 5min in Group IV and HM, and decreased in Group HV, IM and IM at 60min. Na^+ and Ca^<2+> decreased from 5 min, and the decreases lasted till 60 min. No correlationship was occurred in increases in Mb and K values. It is indicated that we should be cautious to avoid myoglobinemia or possibly malignant hyperthermia, during isoflurane anesthesia.