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INDUCTION OF HGF AFTER LIVER INJURIES AND IDENTIFICATION OF INDUCER FOR HGF

Research Project

Project/Area Number 03680173
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 代謝生物化学
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MATSUMOTO Kunio  Kyushu Univ.,Faculty of Science,Assist., 理学部, 助手 (90201780)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Toshikazu  Kyushu Univ.Faculty of Science,Professor, 理学部, 教授 (00049397)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsHGF / Injurin / Liver Regeneration / Renal Regeneration / TGF-beta / IL-1 / TGF-β1 / 肝細胞増殖因子 / 増殖因子
Research Abstract

Hepatocyte growth factor(HGF)induces mitogenesis,motogenesis and morphogenesis of various epithelial cells,including mature hepatocytes and has been considered to act as a hepatotrophic factor for liver regeneration.We have studied induction of HGF following various injuries in the liver and kidney and identified inducers for HGF.Expression of HGF was rapidly and markedly induced following onset of various liver injuries(hepatitis,partial hepatectomy,etc.) or renal injuries(unilateral nephrectomy,ischemia,HgCl_2-administration,etc.)not only in injured organ but also in distant intact organs such as lung and spleen.Thus HGF seems to act as hepatotrophic and renotropic factor for regeneration of liver and kidney through a paracrine and an endorine mechanisms.We next found the presence of an inducer for expression of HGF in serum of rat with organ injury and named the factor "injurin".Injurin was partially purified from the serum of rats and was found to be acid-and heat-stable proteious factor with Mr of 10-30kDa.In addition to injurin,interleukin-1(IL-1)and heparin also increased HGF synthesis in cultured fibroblasts,whereas transforming growth factor-beta1(TGF-beta1)and glucocorticoids suppressed expression of HGF,acting as negative regulators for HGF.Injurin,IL-1,and heparin may be rapidly secreted following hepatic or renal injuries and induce expression of HGF.On the other hand TGF-beta1 may be involved in the termination of organ regeneration through its potential to suppress HGF expression.HGF and its regulators may have important roles not only for organ regeneration,but also for organogenesis and homeostasis of organs.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (80 results)

All Other

All Publications (80 results)

  • [Publications] K.Matsumoto,H.Tajima and T.Nakamura: "Hepatocyte growth factor is a potent stimulator for human melanocytes DNA syn-thesis and growth." Biochem.Biophys.Res.Commun.176. 45-51 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Kinoshita,S.Hirao,K.Matsumoto,and T.Nakamura: "Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy." Biochem.Biophys.Res.Commun.177. 330-335 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,K.Hashimoto,K.Yoshikawa and T.Nakamura: "Marked stimulation of growth and motility of human keratinocyte by hepatocyte growth factor." Exp.Cell.Res.196. 114-120 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Nagaike,S.Hirao,H.Tajima,S.Noji,S.Taniguchi,K.Matsumoto and T.Nakamura: "Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy." J.Biol.Chem.266. 22781-22784 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Tajima,K.Matsumoto and T.Nakamura: "Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell lines." FEBS Lett.291. 229-232 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Konishi,T.Takehara,T.Tsuji,K.Ohsato,K.Matsumoto and T.Nakamura: "Scatter factor from human embryonic lung fibroblasts is probably identical to hepatocyte growth factor." Biochem.Biophys.Res.Commun.180. 765-773 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,T.Takehara,H.Inoue,M.Hagiya,S.Shimizu and T.Nakamura: "Deletion of kringle domains or the N-terminal hairpin structure in hepatocyte growth factor results in marked decreases in related biological activities." Biochem.Biopys.Res.Commun.181. 691-699 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto and T.Nakamura: "Hepatocyte growth factor:Molecular structure and implications for a central role in liver regeneration." J.Gastroenterol,Hepatol.6. 509-519 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Yanagita,M.Nagaike,H.Ishibashi,Y.Niho,K.Matsumoto and T.Nakamura: "Lung may have an endocrine function producing hepatocyte growth factor in respons to injury of distal organs." Biochem.Biohys.Res.Commun.182. 802-809 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,H.Tajima,M.Hamanoue,S.Kono,T.Kinoshita and T.Nakamura: "Identification and characterization of¨injurin¨,an inducer of expression of the gene for hepatocyte growth factor." Proc.Natl.Acad.Sci.USA. 89. 3800-3804 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Hamanoue,K.Kawaida,S.Takao,H.Shimazu,S.Noji,K.Matsumoto and T.Nakamura: "Rapid and marked induction of HGF mRNA in liver and HGF activity in serum of rats after ischemic of crush liver injury." Hepatology. 16. 1485-1492 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Tajima,K.Matsumoto and T.Nakamura: "Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species." Exp.Cell Res.202. 423-431 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Ishiki,H.Ohnishi,Y.Muto,K.Matsumoto and T.Nakamura: "Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and for potent anti-hepatitis action in vivo." Hepatology. 16. 1227-1235 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Kono,M.Nagaike,K.Matsumoto,and T.Nakamura: "Marked induction of hepatocyte growth factor mRNA in intact kidney and spleen in response to injury of distan organ." Biochem.Biophys.Res.Commun.186. 991-998 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,H.Okazaki,and T.Nakamura: "Up-regulation of hepatocyte growth factor gene expression by interleukin-1 in human skin fibroblasts." Biochem.Biophys.Res.Commun.188. 235-243 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Kagoshima,T.Kinoshita,K.Matsumoto,and T.Nakamura: "Developmental changes in hepatocyte growth factor mRNA and its receptor in rat liver,kidney and lung." Eur.J.Biochem.210. 375-380 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,H.Tajima,H.Okazaki,and T.Nakamura: "Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-β1 and glucocorticoids" J.Biol.Chem.267. 24917-24920 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto and T.Nakamura: "Hepatocyte growth factor:Molecular structure,roles in liver regeneration,and other biological functions." Critial Reviews in Oncogenesis. 3. 27-54 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto and T.Nakamura: "Role of hepatocyte growth factor in liver regeneration.In“Cellular and Molecular Basis of Liver Cirrhosis"" Inserm/eurotext, 255-264 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto and T.Nakamura(ed.I.D.Goldbergの分担): "Roles of HGF as a pleiotropic factor in organ regeneration.In“Hepatocyte Growth Factor-Scatter Factor and c-Met Receptor"" Birkhauser Verlag, 225-249 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,H.Tajima and T.Nakamura: "Hepatocyte growth factor is a potent stimulator for human melanocytes DNA synthesis and growth." Biochem.Biophys.Res.Commun. 176. 45-51 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Kinoshita,S.Hirao,K.Matsumoto,and T.Nakamura: "Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy." Biochem.Biophys.Res.Commun. 177. 330-335 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Nagaike,S.Hirao,H.Tajima,S.Noji,S.Taniguchi,K.Matsumoto and T.Nakamura: "Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy." J.Biol.Chem. 266. 22781-22784 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,K.Hashimoto,K.Yoshikawa and T.Nakamura: "Marked stimulation of growth and motility of human keratinocyte by hepatocyte growth factor." Exp.Cell.Res. 196. 114-120 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Tajima,K.Matsumoto and T.Nakamura: "Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell lines." FEBS Lett. 291. 229-232 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Konishi,T.Takehara,T.Tsuji,K.Ohsato,K.Matsumoto and T.Nakamura: "Scatter factor from human embryonic lung fibroblasts is probably identical to hepatocyte growth factor." Biochem.Biophys.Res.Commun. 180. 765-773 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,T.Takehara,H.Inoue,M.Hagiya,S.Shimizu and T.Nakamura: "Deletion of kringle domains or the N-terminal hairpin structure in hepatocyte growth factor results in marked decreases in related biological activities." Biochem.Biopys.Res.Commun. 181. 691-699 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto and T.Nakamura: "Hepatocyte growth factor:molecular structure and implications for a central role in liver regeneration." J.Gastroenterol.Hepatol. 6. 509-519 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Yanagita,M.Nagaike,H.Ishibashi,Y.Niho,K.Matsumoto and T.Nakamura: "Lung may have an endocrine function producing hepatocyte growth factor in response to injury of distal organs." Biochem.Biophys.Res.Commun.182. 802-809 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,H.Tajima,M.Hamanoue,S.Kono,T.Kinoshita and T.Nakamura: "Identification and characterization of "injurin",an inducer of expression of the gene for hepatocyte growth factor." Proc.Natl.Acad.Sci.USA. 89. 3800-3804 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Tajima,K.Matsumoto and T.Nakamura: "Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species." Exp.Cell Res. 202. 423-431 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Ishiki,H.Ohnishi,Y.Muto,K.Matsumoto and T.Nakamura: "Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and for potent anti-hepatitis action in vivo." Hepatology. 16. 1227-1235 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Hamanoue,K.Kawaida,S.Takao,H.Shimazu,S.Noji,K.Matsumoto and T.Nakamura: "Rapid and marked induction of HGF mRNA in liver and HGF activity in serum of rats after ischemic of crush liver injury." Hepatology. 16. 1485-1492 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Kono,M.Nagaike,K.Matsumoto,and T.Nakamura: "Marked induction of hepatocyte growth factor mRNA in intact kidney and spleen in response to injury of distant organ." Biochem.Biophys.Res.Commun. 186. 991-998 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,H.Okazaki,and T.Nakamura: "Up-regulation of hepatocyte growth factor gene expression by interleukin-1 in human skin fibroblasts." Biochem.Biophys.Res.Commun. 188. 235-243 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Kagoshima,T.Kinoshita,K.Matsumoto,and T.Nakamura: "Developmental changes in hepatocyte growth factor mRNA and its receptor in rat liver,kidney and lung." Eur.J.Biochem. 210. 375-380 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,H.Tajima,H.Okazaki,and T.Nakamura: "Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-beta1 and glucocorticoids." J.Biol.Chem. 267. 24917-24920 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto and T.Nakamura:Hepatocyte growth factor: "Molecular structure,roles in liver regeneration,and other biological functions." Critial Reviews in Oncogenesis. 3. 27-54 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto and T.Nakamura: Inserm/Eurotext. Role of hepatocyte growth factor in liver regeneration.In"Cellular and Molecular Basis of Liver Cirrhosis", 255-264 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto and T.Nakamura: Birkhauser Verlag. Roles of HGF as a pleiotropic factor in organ regeneration.In "Hepatocyte Growth Factor-Scatter Factor and c-Met Receptor"(ed.I.D.Goldberg), 225-249 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Matsumoto,H.Tajima,M.Hamanoue,S.Kono,T.Kinoshita,& T.Nakamura: "Identification and characterization of“injurin",an inducer of the gene expression of hepatocyte growth factor." Proc.Natl.Acad.Sci.USA. 89. 3800-3804 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Ishiki,H.Ohnishi,Y.Muto,K.Matsumoto,& T.Nakamura: "Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and for potent anti-hepatitis action in vivo." Hepatology. 16. 1227-1235 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Hamanoue,K.Kawaida,S.Takao,H.Shimazu,S.Noji,K.Matsumoto,& T.Nakamura: "Rapid and marked induction of hepatocyte growth factor during liver regeneration after ischemic or crush liver injury." Hepatology. 16. 1485-1492 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Kono,M.Nagaike,K.Matsumoto,& T.Nakamura: "Marked induction of hepatocyte growth factor mRNA in intact kidney and spleen in response to injury of distant organs." Biochem.Biophys.Res.Commun.186. 991-998 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Matsumoto,H.Okazaki,& T.Nakamura: "Up-regulation of hepatocyte growth factor mRNA by interleukin-1 in human skin fibroblasts." Biochem.Biophys.Res.Commun.188. 235-243 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Matsumoto,H.Tajima,H.Okazaki,& T.Nakamura: "Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-β1 and glucocorticoids." J.Biol.Chem.267. 24917-24920 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Matsumoto and T.Nakamura: "Hepatocyte growth factor:molecular structure and implications for a central role in liver regeneration." J.Gastroenterol.Hepatol.6. 509-519 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Hashiro,K.Matsumoto,H.Okumura,K.Hashimoto,and K.Yoshikawa: "Growth inhibition of human keratinocyte by antisence cーmycoligomer is not coupled to induction of differentiation" Biochem.Biophys.Res.Commun.174. 287-292 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Matsumoto,H.Tajima,and T.Nakamura: "Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth." Biochem.Biophys.Res.Commun.176. 45-51 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Matsumoto,Y.Azuma,M.Kiyoki,H.Okumura,K.Hashimoto,and K.Yoshikawa: "Involvement of endogenously produced 1,25ーdihydroxyvitamin D_3 in the growth and differentiation of human keratinocytes." Biochim.Biophys.Acta.1092. 311-318 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Higashiyama,K.Matsumoto,K.Hashimoto,and K.Yoshikawa: "Increased production of transforming growth factorーalpha in psoriatic epidermis." J.Dermatol.117-119 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Kinoshita,S.Hirao,K.Matsumoto,and T.Nakamura: "Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy." Biochem.Biophys.Res.Commun.177. 330-335 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Nagaike,S.Hirao,H.Tajima,S.Noji,S.Taniguchi,K.Matsumoto,and T.Nakamura: "Renotropic function of hepatocyte growth factor in renal regeneration after unilateral unilateral nephrectomy." J.Biol.Chem.22781-22784 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Matsumoto and T.Nakamura: "Hepatocyte growth factor:molecular structure,roles in liver regeneration,and other biological functions." Critical Rev.Oncogenesis. 3. 27-54 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Matsumoto and T.Nakamura: "Role of hepatocyte growth factor in liver regeneration." In Cellular and Molecular Basis of Liver Cirrhosis(Inserm/Eurotext). 255-264 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Matsumoto,K.Hashimoto,K.Yoshikawa,and T.Nakamura: "Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor." Exp.Cell Res.196. 114-120 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Tajima,K.Matsumto,and T.Nakamuara: "Hepatocyte growth factor has a potent antiーproliferative activity for various tumor cell lines." FEBS Lett.291. 229-232 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] "Identification of a fibroblastーderived epithelial morphogen as hepatocyte growth factor." Cell. 67. 901-908 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Hashiro,K.Matsumoto,K.Hashimoto,and K.Yoshikawa: "Stimulation of fibronectin secretion in cultured human keratinocytes by transforming growth factorーbeta not by other growth inhibitory substances." J.Dermatol.18. 252-257 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Konishi,T.Takehara,T.Tsuji,K.Ohsato,K.Matsumoto,and T.Nakamura: "Scatter factor from human embryonic lung fibroblasts is probably identical to hepatocyte growth factor." Biochem.Biophys.Res.Commun.180. 765-773 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Matsumoto,T.Takehara,H.Inoue,M.Hagiya,S.Shimizu and T.Nakamura: "Deletion of kringle domains or the Nーterminal hairpin structure in hepatocyte growth factor results in marked decrease in related biological activities." Biochem.Biophys.Res.Commun.181. 691-699 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Yanagita,M.Nagaike,H.Ishibashi,Y.Niho,K.Matsumoto and T.Nakamura: "Lung may have an endocrine function producing hepatocyte growth factor in response to injury of distal organs." Biochem.Biophys.Res.Commun.802-809 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Sugai,K.Hashimoto,A.Kikuchi,S.Inoue,H.Okumura,K.Matsumoto,Y.Goto,H.Ohgai,K.Moriishi,B.Shuto,K.Yoshikawa,H.Suginaka and Y.Takai: "Epidermal differentiation inhibitor(EDIN)ADPーribosylates small GTPーbinding protein and induces hyperplasia of epidermis." J.Biol.Chem.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Matsumoto,H.Tajima,M.Hamanoue,S.Kono,T.Kinoshita and T.Nakamura: "Identification and characterization of ″injurin″,an inducer of the gene expression of hepatocyte growth factor." Proc.Natl.Acad.Sci.USA,89. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Tajima,K.Matsumoto and T.Nakamura: "Regulation of cell growth and cell motility by hepatocyte growth factor and its receptor expression in various typespof cells." Exp.Cell Res.,submitted to publication.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Hamanoue,K.Kawaida,S.Takao,H.Shimazu,S.Noji,K.Matsumoto and T.Nakamura: "Rapid and marked induction of HGF mRNA in liver and HGF activity in serum of rats after ischemic or crush liver injury." Hepatology. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Takehara,K.Matsumoto and T.Nakamura: "Cell densityーdependent regulation of albumin synthesis and DNA synthesis in rat hepatocytes by hepatocyte growth factor." J.Biochem.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Y.Ishiki,H.Ohnishi,Y.Muto,K.Matsumoto and T.Nakamura: "Direct evidence that hepatocyte growth factor is ahepatotrophic factor for liver regeneration and for potent antiーhepatitis action in vivo." Hepatology. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Johnson,T.Nakamura,K.Matsumoto,K.Kochhar and A.Iyer: "HGFーinduced scattering and mitogenesis of normal mouse liver cells are independent events." FEBS Lett.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.S.Pepper,K.Matsumoto,T.Nakamura,L.Orci and R.Montesano: "Hepatocyte growth factor induces urokinaseーtype plasminogen activator and plasminogen activator inhibitorー1 in MDCK epithelial cells." J.Biol.Chem.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] T Igawa,S Kanda,H Kanetake,Y Saitoh,K Matsumoto,and T Nakamura: "Hepatocyte growth factor may function as a renotropic factor for regeneration in rats with acutely induced renal injury." Kidney International,submitted to publication.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松本 邦夫,中村 敏一: ""肝細胞増殖因子(HGF)の構造と機能"" 代謝. 28. 3-12 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木下 大成,松本 邦夫,中村 敏一: ""HGFの多様な生理作用と組織再生"" 「サイトカインと情報伝達」実験医学. 144-153 (1992)

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      1991 Annual Research Report
  • [Publications] K.Matsumoto and T.Nakamura: "Protocols In Cell & Tissue Culture,(Collagenase and Hyaluronidase)" John & Wiley, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 堀田 安男,大熊 勝治 編,松本 邦夫,中村 敏一: "肝細胞の培養法「細胞生物学実験法1」" 広川書店, (1992)

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      1991 Annual Research Report
  • [Publications] 松本 邦夫,中村 敏一: ""肝細胞の培養法"細胞生物学実験法" 広川書店, (1992)

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      1991 Annual Research Report
  • [Publications] 松本 邦夫,中村 敏一: "肝細胞「生物薬科学実験法」" 広川書店, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木下 大成,松本 邦夫,中村 敏一: "肝細胞増殖因子(HGF)〜精製、アッセイ、応用〜「生物薬科学実験法」" 広川書店, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松本 邦夫,中村 敏一: "肝臓毒性「動物代替試験法」" 広川書店, (1992)

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      1991 Annual Research Report
  • [Publications] 松本 邦夫,中村 敏一: "″HGI″細胞成長因子(日本組織培養学会編)" 朝倉書店, (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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