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Evaluation of the stunned myocardium with radionuclide methods

Research Project

Project/Area Number 03807055
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

KAMBARA Hirofumi  Kyoto University, College of Medical Technology, Professor, 医療技術短期大学部, 教授 (50109005)

Co-Investigator(Kenkyū-buntansha) NOHARA Ryuji  Kyoto University, Dept of Medicine, Assistant Lecturer, 医学部(第3内科), 助手 (80180769)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1992: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1991: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsmyocardial stunning / stunned myocardium / coronary reperfusion / myocardial ischemia / myocardial blood flow / myocardial function / metabolic stunning / radionuclide / myocardial function / Myocardial stunning / 心筋梗塞症 / 心筋虚血 / ^<18>ーFDGポジトロン / diltiazem / ^<123>IーMIBG(metaiodoーbenzylーguanidine) / ^<99m>TcーPYP(pyrophosphate) / ^<123>IーBMIPP(betaーmethyliodophenyl pentadecanoic acid)
Research Abstract

Mechanism of myocardial stunning was studied with radionuclide met hods. Canine coronary arteries were ligated for 30 min andreperfused for 2 hrs, when myocardial blood flow and myocardial Ca uptake (^<99m>Tc pyrophosphate (PYP) uptake) was examined. Bloodflow was normalized but echocardiography demonstrated reduced wall motion associated with in creased PYP. Administration of Ca antagonists fascilitated a recovery of wall motion and suppress the PYP uptake. In canine models, ^<123>I-metaiodo-benzyl-guanidine, which was closely correlated with myocardial cat echolamine con-tents, was not reduced in the stunned myocardium but was in the infarction. This suggests that depletion of catecholamine at thenerve endings may not present in the stunned myocardium but may in the extreme ischemia such as infarction. According to the analysis with ^<123>I-beta-methyliodophenyl pentadecanoic acid and ^<18>F- fluorodeoxy-glucose, lipid metabolism was suppressed and anaero-bic glucose metabolism was accelarated in spite of recovery of blood flow (metabolic stunning).
Clinically, increased myocardial PYP uptake are present in patients with nonQ-infarction, suggesting Ca are closely associ-ated with stunning. In the stunned, ^<11>C-acetate clearance was also low indicating reduced regional O_2 consumption and normali-zed with dobutamine infusion.
Thus, myocardial stunning with impaired wall motion seems tobe related with increased Ca uptake and reduced energy consumption.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] 河本 雅秀,玉木 長良,米倉 義晴,高橋 範雄,小野 晋司,野原 隆司,神原 経文,他: "心筋梗塞症例におけるI-123-BMIPPシンチグラフィの臨床的意義" 核医学. 28. 1081-1088 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 小野 晋司,野原 隆司,奥田 和美,Mohiuddin IH,山田 武彦,神原 啓文,他: "I-123-BMIPPによる心筋代謝イメージング:心筋灌流および壁運動との対比検討" 心臓. 24(suppl). 82-89 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 神原 経文,野原 隆司: "Stunned myocardiumの核医学的検討" Tokyo Heart Journal. 12. 105-107 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 神原 啓文: "急性心筋梗塞:診断と治療の進歩:PETで何がわかるか" 日本内科学会雑誌. 81. 53-57 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 日比野 均,神原 啓文: "hibernationとstunned myocardium" 臨床医. 19. 92-96 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hashimoto T, Kambara H, Fudo T, Tamaki S, Takatsu Y, Hattori R, et al.: "Significance of technetium-99m/thallium-201 overlap on simultaneous dual emission computed tomography in acute myocardial infa rction" Am J Cardiol. 61. 1181-1186 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fudo T, Kambara H, Hashimoto T, Hayashi M, Nohara R, Tamaki N, et al.: "F-18 deoxyglucose and stress N-13 ammonia positron emission tomography in anterior wall healed myocardial infarction" Am J Cardiol. 61. 1191-1197 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hashimoto T, Kambara H, Fudo T, Hayashi M, Tamaki S, Tokunaga S, et al.: "Non-Q wave versus Q wave myocardial infarction:Regional myocardial metabolism and blood flow assessed by positron emission tomography" Jpn Circ J. 12. 88-93 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kambara H, Fudo T, Hashimoto T, Hayashi M, Kawai C, Tamaki N, et al.: "Silent myocardial ischemia in patients with myocardial infarction:Evaluation with positron emission computed tomography" Jpn Circ J. 53. 1437-1443 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nohara R, Kambara H, Okuda K, Ono S, Tamaki N, Konishi J, Kawai C: "Effects of cardiac sympatheric nervous system on the stunned myocardium:Experimental study with I-123-metaiodobenzyl guanidine" Jpn Circ J. 55. 893-899 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamaki N, Kawamoto M, Takahashi N, Yonekura Y, Magata Y, Nohara R, et al.: "Metabolic reserve in normal myocardium assessed by positron emission tomography C-11 plamitate" Ann Nucl Med. 5. 53-58 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ono S, Nahara R, Kambara H, Okuda K, Kawai C: "Regional myocardial perfusion and glucose metabolism in experimental left bunble branch block" Circulation. 85. 1125-1131 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nohara R, Kambara H, Okuda K, Ono S, Tamaki N, Konishi J, Kawai C: "Effects of diltiazem on stunned myocardium evaluated with 99m-Tc-Pyrophosphate imaging in canine heart" Jpn Circ J. 56. 262-271 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kambara H, Nohara R, Tamaki N, Ono S, Konishi J, Kawai C: "Positron emmision tomography:Usefulness in assessing myocardia lviability" Jpn Circ J. 56. 608-613 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamaki N, Kawamoto M, Yonekura Y, Fujibayashi Y, Takahashi N, et al.: "Myocardial oxidative metabolism in normal subjects in fasting,glucose loading and dobutamine infusion states" Ann Nucl Med. 6. 221-228 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamaki N, Kawamoto M, Yonekura Y, Fujibayashi Y, Takahashi N, et al.: "Regional metabolic Abnormality in relation to perfusion and wallmotion in Patients with myocadial infarction:Assessment with emissiontomography using an iodinated branched fatty acid analog" J Nucl Med. 33. 659-667 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hashimoto T, Kambara H, Fudo T, Tamaki S, Takatsu Y, Hattori R, Tokunaga S, Kawai C, Uozu K: "Significance of technetium-99m/thallium-201 overlap on simultaneous dual emission computed tomography in acute myocardial infarction" Am J Cardiol. 61(15). 1181-1186 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fudo T, Kambara H, Hashimoto T, Hayashi M, Nohara R, Tamaki N, Yonekura Y, Senda M, Konishi J, Kawai C: "F-18 deoxyglucose and stress N-13 ammonia positron emission tomography in anterior wall healed myocardial infarction" Am J Cardiol. 61(15). 1191-1197 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hashimoto T, Kambara H, Fudo T, Hayashi M, Tamaki S, Tokunaga S, Tamaki N, Yonekura Y, Konishi J, Kawai C: "Non-Q wave versus Q wave myocardial infarction: Regional myocardial metabolism and blood flow assessed by positron emission tomography" J Am Coll Cardiol. 12(1). 88-93 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kambara H, Fudo T, Hashimoto T, Hayashi M, Kawai C, Tamaki N, Yamashita K, Yonekura Y, Konishi J: "Silent myocardial ischemia in patients with myocardial infarction: Evaluation with positron emission computed tomography" Jpn Circ J. 53(11). 1437-1443 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nohara R, Kambara H, Okuda K, Ono S, Tamaki N, Konishi J, Kawai C: "Effects of cardiac sympathetic nervous system on the stunned myocardium: Experimental study with I-123-met aiodobenzyl guanidine" Jpn Circ J. 55(9). 893-899 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamaki N, Kawamoto M, Takahashi N, Yonekura Y, Magata Y, Nohara R, Kambara H, Kawai C, Konishi J: "Metabolic reserve in normal myocardium assessed by positron emission tomography C-11 plamitate" Ann Nucl Med. 5(2). 53-58 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ono S, Nohara R, Kambara H, Okuda K, Kawai C: "Regional myocardial perfusion and glucose metabolism in experimental left bundle branch block" Circulation. 85(3). 1125-1131 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nohara R, Kambara H, Okuda K, Ono S, Tamaki N, Konishi J, Kawai C: "Effects of diltiazem on stunned myocardium evaluated with 99m-Tc-Pyrophosphate imaging in canine heart" Jpn Circ J. 56(3). 262-271 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kambara H, Nohara R, Tamaki N, Ono S, Konishi J, Kawai C: "Positron emmision tomography: Usefulness in assessing myocardial viability" Jpn Circ J. 56(6). 608-613 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamaki N, Magata Y, Takahashi N, Kawamoto M, Torizuka T, Yonekura Y, Nishizawa S, Sadato N, Tadamura E, Ono S, Nohara R, Kambara H, Konishi J: "Myocardial oxidative metabolism in normal subjects in fasting, glucose loading and dobutamine infusion states" Ann Nucl Med. 6(4). 221-228 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamaki N, Kawamoto M, Yonekura Y, Fujibayashi Y, Takahashi N, Konishi J, Nohara R, Kambara H, Kawai C, Ikekubo K, Kato H: "Regional metabolic abnormality in relation to perfusion and wallmotion in patients with myocardial infarction: Assessment with emissiontomography using an iodinated branched fatty acid analog" J Nucl Med. 33(5). 659-667 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 小野 晋司,野原 隆司,奥田 和美,Mohiuddin IH,山田 武彦,神原 啓文,他: "I-123-BMIPPによる心筋代謝イメージング:心筋潅流および壁運動との対比検討" 心臓. 24(suppl). 82-89 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 神原 啓文,野原 隆司: "Stunned myocardiumの核医学的検討" Tokyo Heart Journal. 12. 105-107 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 神原 啓文: "急性心筋梗塞:診断と治療の進歩:PETで何がわかるか" 日本内科学会雑誌. 81. 53-57 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ono S, Nohara R, Kambara H, Okuda K, Kawai C: "Regional myocardial perfusion and glucose metabolism in experim ental left bundle branch block" Circulation. 85. 1125-1131 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nohara R, Kambara H, Okuda K, Ono S, Tamaki N, Konishi J, Kawai C: "Effects of diltiazem on stunned myocardium evaluated with 99m-TC-Pyrophosphate imaging in canine heart" Jpn Circ J. 56. 262-271 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kambara H, Nohara R, Tamaki N, Ono S, Konishi J, Kawai C: "Positron emmision tomography: Usefulness in assessing myocardialviability" Jpn Circ J. 56. 608-613 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tamaki N, Magata Y, Takahashi N, Kawamoto M, Torizuka T, et al.: "Myocardial oxidative metabolism in normal subjects in fasting,glucose loading and dobutamine infusion states" Ann Nucl Med. 6. 221-228 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tamaki N, Kawamoto M, Yonekura Y, Fujibayashi Y, Takahashi N, et al.: "Regional metabolic abnormality in relation to perfusion and wallmotion in patients with myocardial infarction: Assessment with emissiontomography using an iodinated branched fatty acid analog" J Nucl Med. 33. 659-667 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nohara R,et al: "Effect of diltiazem on stunned myocardium evaluated with ^<998>TcーPYP imaging in canine heart." Jpn Circ. 56. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Nohara R,et al: "Effect of cardiac sympathetic nervous system on the stunned myocardium Experimental study with ^<123>IーMIBG." Jpn Circ J. 55. 893-897 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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