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The assessment of liver functional reserve by the measurement of the amino acids utility rate and hepatic protein synthesis rate.

Research Project

Project/Area Number 03807083
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionSurgery(II), Chiba University, School of Medicine

Principal Investigator

ASANO Takehide  Surgery (II), Lecturer, 医学部, 講師 (80143311)

Co-Investigator(Kenkyū-buntansha) KIKUTI Tosiyuki  Surgery (II), Assistant, 医学部, 助手 (30231278)
ISOMO Kaichi  Surgery (II), Professor, 医学部, 教授 (70009489)
落合 武徳  千葉大学, 医学部・外科学第二, 助教授 (80114255)
榎本 和夫  千葉大学, 医学部・附属病院・第二外科, 助手 (70223659)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsLiver function / Liver functional reserve / Amino acids / Amino acids utility index / Hepatic protein synthesis / Hepatic resection / Needle biopsy / Liver cirrhosis / 肝機能検査 / 肝予備能 / 蛋白合成率 / リドカイン / monoethylglycinexylidide(MEGX) / 肝切除術
Research Abstract

In order to asses the liver functional reserve, we investigated clinical and experimental hepatic resection cases using the procedure of 1) hepatic amino acids utility index and 2) hepatic protein synthesis rate of needle biopsied liver specimens preoperatively and compared with their post operative liver function. The amino acids utility index statistically correlated well with the degree of hepatic disorders in both experimental and clinical liver cirrhosis through pre and post operative period. And this index meant the whole liver protein synthetic activity. On the contrary, the hepatic protein synthesis rate of needle biopsied liver (HPS) represented the function of a unit of liver tissue. In the experimental liver cirrhosis and clinical liver cirrhosis cases, this HPS were already accelerated at the unit of liver but not in whole liver function. The acceleration of the HPS at the unit of the liver theoretically have the limitation, the degree of the acceleration of HPS, therefore, meant the decreasing of their functional reserve.
Measuring of the amino acid utility index could bring real time assessment of the liver function, and the HPS showed the functional reserve of the liver. By these data, we might preoperatively decide the hepatic resection mass for the satisfactory post operative liver function.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 中郡 聡夫: "針生検による肝蛋白合成率(HPS)測定と肝機能予備力評価への応用" 日本消化器病学会雑誌. 88(8). 1566-1570 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Toru KUBOTA: "Hepatic protein symthesis rate of biopsied tissue in the ossessment of preservation Solution" Transplantation Proceedingo. 24(4). 1625-1627 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 貝沼 修: "塩塩リドカイン代謝産物monoethylglycinexylidide測定による肝機能評価" 日本消化器外科学会雑誌. 24(9). (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu KAINUMA: "Assessment of energy status and fructouse metabolism in obstructive joundiced liver by 31p-MRS" J.of Surgical Research. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 浅野 武秀: "MEGXテスト,肝蛋白合成機能測定による肝予備力評価" 第4回日本肝胆膵外科フォーラム抄録集. 11 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakagouri T, Asano T, Goto T, Kenmochi K and Isono K: "Hepatic protein synthesis rate as an in ex of hepatic functional reserve in human liver." Japanese J of the gastroenterological Society. 88(8). 1565-1570 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kubota T, Asano T, Nakagouri T, Arita S, Kainuma O and Isono K: "Hepatic protein synthesis rate of biopsied liver tissue in the assessment of preservation solution." Transplantation Proceedings. 24(4). 1625-1627 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kainuma O, Asano T, Enomoto K, Kubota T and Isono K: "Measuring of the lidocaine metabolite, monoethylglycinexylidide, as a liver functional test for cirrhosis and obstructive jaundice." Japanese J of the gastroenterological surgical society. 24(9). 2354-2357 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kainuma O, Asano T, and Isono K: "Assessment of energy status and fructose metabolism in obstructive jaundiced liver by 31P-MRS." J of Surgical Research. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Asano T, Kainuma O Kubota T, Nakagouri T, Enomoto K, Tokoro Y, Matsui Y, Jingu K, Maruyama M, Miyauchi H, Nagashima T, Kobayashi S, Kikuchi T and Isono K: "The assessment of liver functional reserve by MEGX test and hepatic protein synthesis measuring" The 4th annual meeting of the Japanese Forum of the hepatobiliary and pancreas surgery, Nov.(1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 甲郡 聡夫: "針生検による肝蛋白合成率(HPS)測定と肝機能予備力評価への応用" 日本消化器病学会雑誌. 88(8). 1566-1570 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Toru Kubota: "Hepatic Protein Synthesis rate of biopsied liver tissve in the assessment of Preservation solution." Tronsplntation Proceedings. 24(4). 1625-1627 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 貝沼 修: "塩酸リドカイン代謝産物monoethy lglycinexy lidide 測定による肝機能評価" 日本消化器外科学会雑誌. 24(9). 2354-2357 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Osamu Kainuma: "Assessment of energy status and fructose metabolism obstructire jaundiced liver by 31P-MRS." J.of Surgical Research. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 浅野 武秀: "MEGXテスト,肝蛋白合成能測定による肝予備力評価" 第4回日本肝胆膵外科フォーラム抄録集. 11- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 貝沼 修,浅野 武秀,他: "塩酸リドカイン代謝産物 monoethyl glycinexylidide測定による肝機能評価" 日本消化器外科学会雑誌. 24. 2354-2357 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 後藤 剛貞,浅野 武秀,他: "アミノ酸利用指数aminoacid utility indexによる肝機能評価と手術浸襲" 日本消化器外科学会雑誌. 24. 38-44 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 中郡 聡夫,浅野 武秀,他: "針生検法による肝蛋白合成率(HPS)測定と肝機能予備力評価への応用" 日本消化器病学会雑誌. 88. 1566-1570 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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