| Project/Area Number | 03807083 |
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Surgery(II), Chiba University, School of Medicine |
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Principal Investigator |
ASANO Takehide Surgery (II), Lecturer, 医学部, 講師 (80143311)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUTI Tosiyuki Surgery (II), Assistant, 医学部, 助手 (30231278)
ISOMO Kaichi Surgery (II), Professor, 医学部, 教授 (70009489)
落合 武徳 千葉大学, 医学部・外科学第二, 助教授 (80114255)
榎本 和夫 千葉大学, 医学部・附属病院・第二外科, 助手 (70223659)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed(Fiscal Year 1992)
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| Budget Amount *help |
¥1,800,000 (Direct Cost : ¥1,800,000)
Fiscal Year 1992 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 1991 : ¥1,300,000 (Direct Cost : ¥1,300,000)
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| Keywords | Liver function / Liver functional reserve / Amino acids / Amino acids utility index / Hepatic protein synthesis / Hepatic resection / Needle biopsy / Liver cirrhosis / 肝機能検査 / 肝予備能 / 蛋白合成率 / リドカイン / monoethylglycinexylidide(MEGX) / 肝切除術 |
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| Research Abstract |
In order to asses the liver functional reserve, we investigated clinical and experimental hepatic resection cases using the procedure of 1) hepatic amino acids utility index and 2) hepatic protein synthesis rate of needle biopsied liver specimens preoperatively and compared with their post operative liver function. The amino acids utility index statistically correlated well with the degree of hepatic disorders in both experimental and clinical liver cirrhosis through pre and post operative period. And this index meant the whole liver protein synthetic activity. On the contrary, the hepatic protein synthesis rate of needle biopsied liver (HPS) represented the function of a unit of liver tissue. In the experimental liver cirrhosis and clinical liver cirrhosis cases, this HPS were already accelerated at the unit of liver but not in whole liver function. The acceleration of the HPS at the unit of the liver theoretically have the limitation, the degree of the acceleration of HPS, therefore, meant the decreasing of their functional reserve.
Measuring of the amino acid utility index could bring real time assessment of the liver function, and the HPS showed the functional reserve of the liver. By these data, we might preoperatively decide the hepatic resection mass for the satisfactory post operative liver function.
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