A study on a development of a retinal lattice degeneration
Project/Area Number |
03807117
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Ophthalmology
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Research Institution | HIROSHIMA UNIVERSITY |
Principal Investigator |
SAKATA Hiroshi Hiroshima University Medical Hospital Assistant Professor, 医学部・附属病院, 講師 (50093761)
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Project Period (FY) |
1991 – 1993
|
Project Status |
Completed (Fiscal Year 1993)
|
Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1993: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1992: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
Keywords | Superior oblique muscle / Lattice degeneration / 上斜筋牽引 |
Research Abstract |
1. Materials and Methods A tendon of superior oblique muscle (SOM) was exposed, and looped by a 4-0 silk thread in a newborn rabbit. The silk thread was connected with a 2-0 nylon from a handmade vibrator which worked by a magnetic morter. A contraction of SOM forced on hour everyday during a various period (1 to 3 months). An eye ball was enucleated after a non-stimulated period (2 to 3 months), and macroscopically or microscopically observed. 2. Result (1) macroscopic findings : A retina below the insertion of SOM to a sclera showed a slightly diffuse discoloration, compared to a control, at 2 to 3 months. (2) microscopic findings : A choroid adjacent to the insertion of SOM to a sclera had a strong edema at 2 months, and a slight atrophy at 3 months. A sclera was thickened, and the collagen fibers was irregularly arranged. But an architecture of the retina was normal at all the time. 3. A further perspection Based upon histological changes in the present study and a known physiological role of a choroid in a maintenance of retinal architecture and function, there is a high possibility that a retina may, in the future, develop a histological change like a lattice degeneration or something in these rabbit in which SOM was forced.
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Report
(4 results)
Research Products
(2 results)