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Study on the development of the DNA databank

Research Project

Project/Area Number 04041112
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research InstitutionNational Institute of Genetics (NIG)

Principal Investigator

GOJOBORI Takashi  NIG,DNA Research Center, 遺伝情報研究センター, 教授 (50162136)

Co-Investigator(Kenkyū-buntansha) BERNARDI G.  Jack Monod Institute, ジャックモノー研究所, 教授
GO Mitiko  Nagoya Univ., Fac.Science, 理学部, 教授 (70037290)
YOSHIKAWA Hiroshi  Nara Advanced Institute of Science and Technology, バイオサイエンス研究科, 研究科長 (70019876)
ISONO Katsumi  Kobe Univ., Fac.Science, 理学部, 教授 (70011640)
IMANISHI Tadashi  NIG,DNA Research Center, 遺伝情報研究センター, 助手 (80270461)
IKEO Kazuho  NIG,DNA Research Center, 遺伝情報研究センター, 助手 (20249949)
SAITOU Naruya  NIG,Department of Population Genetics, 集団遺伝研究系, 助教授 (30192587)
TATENO Yoshio  NIG,DNA Research Center, 遺伝情報研究センター, 教授 (00202424)
DOOLITTLE R.  米国カリフォルニア大学, サンディエゴ校, 教授
KAFATOS F.C.  欧州分子生物学研究所, 所長
長谷川 政美  統計数理研究所, 教授 (60011657)
北上 始  富士通研究所, 研究員 (50234240)
鵜川 義弘  農水省農業生物資源研究所, DNA管理情報科, 科長 (20232803)
BAIROCH Amos  ジュネーブ大学, 教授
FUCHS Rainer  欧州分子生物学研究所, EMBLデータライブラリー, 研究員
OSTELL Jim  米国国立バイオテクノロジー情報センター研究所, 研究員
山崎 由紀子  国立遺伝学研究所, 遺伝情報研究センター, 助手 (00239956)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥26,000,000)
Fiscal Year 1994: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 1993: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 1992: ¥9,000,000 (Direct Cost: ¥9,000,000)
KeywordsDNA / Nucleotide sequence / Databank / Database / Molecular evolution / Gene / Computer / Molecular biology / DDBJ / GenBank / EMBL / コンピュータネットワーク / 生命情報学 / 国際DNAデータベース / NCBI / 生物情報学 / 遺伝情報 / 国際共同構築
Research Abstract

The international nucleotide sequence database is constructed through the international collaboration among Europe (EBI ; European Bioinformatics Institute), U.S.A.(NCBI ; National Center for Biotechnology Information), and Japan (DDBJ ; DNA Data Bank of Japan). To proceed this international collaboration more smoothly, two international meetings (advisory and collaborative) are held annually. Because the originally planned two meetings were not held within this fiscal year (planned to be held in April 1995), we instead went to EBI and NCBI for discussing collaborative issues. We also visited the newly created NCGR (National Center for Genome Resources) at Santa Fe to find out their current situation and future.
It turned out that NCGR,though its name implies, is not a governmental organization, but a mere private company. However, they does receive a grant from DOE (Department of Energy) for constructing GSDB (Genome Sequence Data Base). We discussed with NCGR and NCBI in detail about the future of USA DNA databanks.
The situation in Europe is much better. EBI is now constructing a new building at the Genome Park, Hinxton, and research activity as well as service activity will be strengthened in the near future.

Report

(3 results)
  • 1994 Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] Gojobori,T.: "Molecular evolution of serine protease and its inhibitor with special reference to domain evolution." Philosophical Transactions:Biological Sciences,The Royal Society. 344. 411-415 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ina,Y.: "Statistical analysis of nucleotide sequences of the hemaggutinin gene of human influenza A viruses." Proc.Natl.Acad.Sci.,U.S.A.91. 8388-8392 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Gojobori,T.: "Evolution of pathogenic viruses with special reference to the rates of synonymous and nonsynonymous substitutions." Jpn.J.Genet.69. 481-488 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Perriere,G.: "NRSub:a non-redundant data base for the Bacillus subtilis genome.Nucleic Acids Research." Nucleic Acids Research. 22. 5525-5529 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ikeo K.: "Different Evolutionary Histories of Kringle and Protease Domains in Serine Proteases-A Typical Example of Domain Evolution." Journal of Mol.Evol.40. 331-336 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shin-i,T.: "DNA Data Bank of Japan and its Bioinformatic Activities." The Biochemist. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitakami,H.: "Toward unification taxonomy databases in a distributed computer environment.in "The Stanford conference,ISMB94"" AAAI Press, 389 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitakami,H.: "Building and Search System for a Large-Scale DNA Database.in "Advances in Mol.Bioinformatics"" IOS Press, 257 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitakami,H.: "YAMATO AND ASUKA:DNA Database Management System in "Proceedings of the 28th Annual Hawaii Int'l Conf.on System Sciences"" IEEE Computer Society Press, 362 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ren F.: "Molecular Evolutionary Phylogenetic Trees Based on Minimum Description Length Principle.in "Proceedings of the 28th Annual Hawaii Int'l Conf.on System Sciences"" IEEE Computer Society Press, 362 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Gojobori, T.: "Molecular evolution of serine protease and its inhibitor with special reference to domain evolution." Philosophical Transactions : Biological Sciences, The Royal Society. 344. 411-415 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ina, Y.: "Statistical analysis of nucleotide sequences of the hemagglutinin gene of human influenza A viruses." Proc.Natl.Acad.Sci., U.S.A.91. 8388-8392 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Gojobori, T.: "Evolution of pathogenic viruses with special reference to the rates of synonymous and nonsynonymous substitutions." Jpn.J.Genet.69. 481-488 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Perriere, G.: "NRSub : a non-redundant data base for the Bacillus subtilis genome. Nucleic Acids Research" Nucleic Acids Research.22. 5525-5529 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ikeo K.: "Different Evolutionary Histories of Kringle and Protease Domains in Serine Proteases-A Typical Example of Domain Evolution." Journal of Mol.Evol.40. 331-336 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shin-i, T.: "DNA Data Bank of Japan and its Bioinformatic Activities." The Biochemist. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitakami, H.: AAAI Press. Toward unification of taxonomy databases in a distributed computer environment. in "The Stanford conference, ISMB94", 389 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitakami, H.: IOS Press. Building and Search System for a Large -Scale DNA Database. in "Advances in Mol.Bioinformatics", 257 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitakami, H.: IEEE Computer Society Press. YAMATO AND ASUKA : DNA Database Management System. in "Proceedings of the 28th Annual Hawaii Int'l Conf. on System Sciences", 362 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ren F.: IEEE Computer Society Press. Molecular Evolutionary Phylogenetic Trees Based on Minimum Description Length Principle. in "Proceedings of the 28th Hawaii Int'l Conf. on System Sciences", 362 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Gojobori,T.: "Molecular evolution of serine protease and its inhibitor with special reference to domain evolution." Philosophical Transactions of the Royal Society,London (Series B). (印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ina,Y.: "Reduction of synonymous substitutions in the core protein gene of hepatitis C virus." Journal of Molecular Evolution. 38. 50-56 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ina,Y.: "Statistical analysis of nucleotide sepuences of the hemagglutinin gene of human influenza A viruses." Proceedings of National Academy of Sciences,U.S.A.(印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Miura,T.: "Phylogenetic subtypes of human T-lymphotropic virus type 1 and their relations to the anthropological background." Proceedings of National Academy of Sciences,U.S.A.(印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ina,Y.: "Mutation pattern of hepatitis B viruses and its implication for the effect of the anti-viral drugs." Molecular Biology and Evolution. (印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Gojobori,T.: "Evolution of pathogenic viruses with special reference to the rates of synonymous and nonsynonymous substitutions." Japanese Jornal of Genetics. (印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Gojobori,T.: "Genetic variability of major histocompatibility complex in human populations.In:Human Population Genetics:A Centennial Tribute to J.B.S.Haldane(Ed.P.Majumder)" Plenum Publishing Corp., pp.67-74 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kitakami,H.: "Building and search system for a large-scale DNA database,In Proceeding of Molecular Bioinformatics,IEE 94 Collaqulun,London" (未定) (印刷中), (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Gojobori,T.,T.Imanishi,N.Saitou,Y.Takata,A.Kimura,Y.Nishimura,H.Miyoshi,T.Mura,K.Tokunaga,H.Tanaka,Y.Konocda,A.Wakisaka,T.Juji,K.Tsuji,and H.Inoko: "Construction of the MHC database." Proeedings of the 11th MHC International Conterence,Oxford Univrsity Press.

    • Related Report
      1992 Annual Research Report
  • [Publications] Gojobori,T.,T.Imanishi,and Y.Ina: "Statistics in the numbers of Panels stored in the MHC database." Proceedings of the 11th MHC International Conferebce,Oxford University Press.

    • Related Report
      1992 Annual Research Report
  • [Publications] Ikeo,K.,Takahashi,and T.Gojobori: "EvoIutionary Origin of a Kunitz-type trypsin inhibitor domain of Alzheimer'sdisease." J.Mol.Evol.34. 536-543 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ina,Y.,M.Mizokami,E.Orito,E.N.Moriyama,M.Yamamoto,and T.Gojobori: "Mutation Pattern of hepatitis B viruses and its implication for the effect of the anti-viral drugs." Mol.Biol.Evol.

    • Related Report
      1992 Annual Research Report
  • [Publications] 五條堀 孝: "「ヒトゲノム計画とDNAデータベース」" 日経サイエンス. 22. 24-26 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 北上 始、山崎 由紀子、鵜川 義弘、池尾 一穂、斎藤 成也、舘野 義男、五條堀 孝: "「関係データベースによる生物情報の構築と検索」" 日本微生物株保存連盟会誌. 8. 172-200 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 五條堀 孝、池尾一穂: "『分子生物学からバイオテクノロジーへ(編集:三浦 謹一郎)』" 共同出版, 205 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 五條堀 孝: "「第16巻分子進化実験法」共編" 日本生化学会編、新生化学実験講座, 209 (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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