Grant-in-Aid for international Scientific Research
|Allocation Type||Single-year Grants|
|Research Institution||Niigata University|
IKUTA Fusahiro Brain Research Institute, Niigata University Professor, 脳研究所, 教授 (20018592)
TAKAHASHI Hitoshi Brain Research Institute, Niigata University, Associate Professor, 脳研究所, 助教授 (90206839)
OYANAGI Kiyomitsu Brain Research Institute, Niigata University, Associate Professor, 脳研究所, 助教授 (00134958)
郭 玉璞 中国, 中国医学科学院, 教授
劉 多三 中国, 白求恩医科大学, 教授
王 慕一 中国, 中国医科大学, 準教授
YU-PU Guo Peking Union Medical College Hospital, People's Republic of china, professor
MU-YI Wang Chinai Medical University, People's Republic of China Associate Professor
DUO-SAN Liu Bethune Medical College, People's Republic of china, Professor
|Project Period (FY)
Completed(Fiscal Year 1992)
|Budget Amount *help
¥3,400,000 (Direct Cost : ¥3,400,000)
Fiscal Year 1992 : ¥3,400,000 (Direct Cost : ¥3,400,000)
|Keywords||multiple sclerosis / Balo disease / concentric sclerosis / demyelinating disease / neurological diseases in China / astrocyte|
This project, launched in 1989, aimed to clarify even a part of the conditions of demylinating disease in China ; the autopsy cases in Chiba were compared with 140 autopsy cases in Japan and the U.S.A.
We visited and thoroughly investigated all potential institutes which might have had autopsy cases of this disease. A copmarative study of Chinese cases and those of Japan and the U.S.A. was carried out at the neuropathological conference in November 1992.
It emerged that 45 out of approximately 100 Chinese cases showed features of demyelinating disease.
Concerning regional distribution, 40% of the Chinese cases of this disease was classified into OS type, in which degeneration is seen in optic never and spinal cord, as against 10% of the American cases and 46% of the Japanese cases, and 20% of the Chinese cases were classified into OCS type, in which degeneration is seen in optic nerve, cerebrum and spinal cord, as against 67% of the American cases and 40% of the Japanese cases.
Moreover, 14 of 45 Chinese cases of demyelinating disease revealed pathological features typical of concentric sclerosis (Balo disease), and it was rather surprising that 30% of OCS type are balo disease. This disease has scarcely been seen in Japan snd the Western countries.
Eleven of 14 cases of Balo disease had clinically diagnosed as encephalitis,and some cases showed slight recovery.
In a few cases, the histology of MS encountered in the Western countries and that of Balo type concentric sclerosis coexisted in the same brain. This strongly suggested that MS and Balo type concentric sclerosis possess the fundamentally similar underlining pathogenesis. The finding of astrocytes reacting in an unusual way in the Balo lesion also supported ehis view.