Grant-in-Aid for Overseas Scientific Survey.
|Research Institution||Kyoto University|
SHIBASAKI Hiroshi Kyoto University, Faculty of Medicine, professor, 医学部, 教授 (30037444)
LUDERS H.O. Cleveland Clinic, USA, 神経内科, 部長
HALLETT Mark National Institutes of Health, NINDS, USA, NINDS, 部長
FREUND H ーJ ドイツ, デュッセルドルフ大学・医学部, 教授
BARRETT Geof 英国ロンドン大学国立神経病院, 神経心理学, 主任研究員
間賀田 泰寛 京都大学, 医学部, 助手 (20209399)
池田 昭夫 京都大学, 医学部, 助手 (90212761)
長峯 隆 京都大学, 医学部, 助手 (10231490)
米倉 義晴 京都大学, 医学部, 助教授 (60135572)
POLICH J. Scripps Institute, San Diego, USA, 研究室長
EISEN A.A. University of British Columbia, Faculty of Medicine, Canada, 医学部, 教授
HARI Riitta Helsinki University of Technology, Finland, 低温研究所, 教授
FREUND H.ーJ. ドイツジュッセルドルフ大学, 医学部, 教授
BARRETT Geef 英国ロンドン大学, 国立神経病院・神経心理部門, 主任研究員
FREUND H.-J. University of Dusseldorf Faculty of Medicine, Germany
BARRETT Geoff National Hospital, Queen Square, London, UK
IKEDA Akio Kyoto University, Faculty of Medicine
MAGATA Yasuhiro Kyoto University, Faculty of Medicine
YONEKURA Yoshiharu Kyoto University, Faculty of Medicine
NAGAMINE Takashi Kyoto University, Faculty of Medicine
|Project Fiscal Year
1992 – 1993
Completed(Fiscal Year 1993)
|Budget Amount *help
¥13,000,000 (Direct Cost : ¥13,000,000)
Fiscal Year 1993 : ¥4,200,000 (Direct Cost : ¥4,200,000)
Fiscal Year 1992 : ¥8,800,000 (Direct Cost : ¥8,800,000)
|Keywords||Voluntary movement / Higher brain function / Noninvasive study / Movement-related cortical potential / Contingent negative variation / Movement-related magnetic field / PET / Regional cerebral blood flow / 随意運動 / 高次脳機能 / 無侵襲的研究 / 運動関連脳電位 / 随伴陰性変動 / 運動関連脳磁図 / 局所脳血流 / 頭皮上分布 / 硬膜下記録|
Having been supported by this International Scientific Research Program for the two years, the following achievements related to cortical mechanisms of motor control were obtained through collaborative studies with investigators from USA, UK, Germany, Canada and Finland by using various noninvasive techniques.
1. Elucidation of generator sources of movement-related cortical potentials
By subdural recording in patients with intractable epilepsy in collaboration with Dr.Luders in Cleveland Clinic, the early electric potential starting about 2 s before the onset of voluntary finger movement (readiness potential) was found to be generated from the hand area of the supplementary motor area (SMA) and that of the primary motor area (M1), both bilaterally. The late negative slope preceding the movement onset by 300 ms was generated more from the contralateral SMA and M1.
2. Comparison of simple and complex movements
Scalp potentials preceding complex sequential finger movements were compared with
those preceding simple simultaneous movements, and the former was found to be associated with more activation not only of SMA but also of bilateral M1 than the latter.
3. Studies on generator mechanisms of contingent negative variation (CNV)
In collaboration with Dr.Barrett of UK and Dr.Polich of USA, CNV was found not to be affected by cerebellar efferent lesion while the readiness potential was absent.
4. Recording of movement-related magnetic field
In collaboration with Dr.Hallett at NIH of USA and with Dr.Hari at Helsinki, magnetic field associated with voluntary finger movement was recorded by 7-as well as by 37-channel magnetometer, respectively, and the generator sources of components immediately preceding and following the movement onset were clarified.
5. Functional imaging by PET
In collaboration with Dr.Hallett of USA and Prof.Freund of German, simple and complex finger movements were compared by measuring an increase of regional cerebral blood flow with PET, and showed an evidence supporting the above electrophysiological findings.
Thus, these noninvasive studies clarified the important roles played by not only SMA but also M1 in the planning and/or execution of voluntary finger movements in humans. Less