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Large-scale knowledge information processing in genome analysis

Research Project

Project/Area Number 04261102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

KANEHISA Minoru  Institute for Chemical Research, Professor, 化学研究所, 教授 (70183275)

Co-Investigator(Kenkyū-buntansha) ISONO Katsumi  Kobe University, Faculty of Science, Professor, 理学部, 教授 (70011640)
YONEZAWA Akinori  University of Tokyo, Graduate School of Science, Professor, 理学系研究科, 教授 (00133116)
MATSUBARA Kenichi  Osaka University, Institute for Molecular and Cellular Biology, Professor, 細胞生体工学センター, 教授 (20037394)
MITAKU Shigeki  Tokyo University of Agriculture and Technology, Professor, 工学部, 教授 (10107542)
TAKAGI Toshihisa  University of Tokyo, Institute of Medical Science, Professor, 医科学研究所, 教授 (30110836)
鈴木 義昭  基礎生物学研究所, 教授 (50132733)
西岡 孝明  京都大学, 化学研究所, 助教授 (80026559)
Project Period (FY) 1991 – 1995
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥168,000,000 (Direct Cost: ¥168,000,000)
Fiscal Year 1996: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1995: ¥30,000,000 (Direct Cost: ¥30,000,000)
Fiscal Year 1994: ¥45,000,000 (Direct Cost: ¥45,000,000)
Fiscal Year 1993: ¥45,000,000 (Direct Cost: ¥45,000,000)
Fiscal Year 1992: ¥45,000,000 (Direct Cost: ¥45,000,000)
KeywordsGenome analysis / Sequence analysis / Structure-function relationship / Database / Network
Research Abstract

The Scientific Research Project on the Priority Area "Genome Informatics" aimed at developing new computational technologies for genome research on human and other organisms. Especially, the project focused on (i) the database problem of how to organize and integrate different types of data being produced by genome analyzes and (ii) the computational problem of how to decipher biological meaning encoded in the sequence data which is the final product by experiments. During the five year period, we published more than 100 original papers in addition to the three volumes of the Genome Informatics Series Proceedings. We also published a number of original and review papers, ducuments, pamphlets, and books in Japanese. The project has been instrumental in establishing the GenomeNet computer network as the informatics infrastructure for biomedical research in Japan and in nurturing the bioinformatics research community by regularly organizing workshops and tutorials. The basic research results, especially for the database problem, have been implemented as practical databases and software products that are internationally made available as a part of the GenomeNet database service.

Report

(6 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] 金久實: "ゲノム情報への招待" 共立出版, 151 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 高木利久、金久實: "ゲノムネットのデータベース利用法" 共立出版, 181 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 金久實: "ゲノム情報への招待" 共立出版, 151 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高木利久、金久實: "ゲノムネットのデータベース利用法" 共立出版, 181 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ogata,H.,Akiyama,Y.,Kanehisa,M.: "A genetic algorithm based molecular modeling technique for RNA stem-loop structures." Nucleic Acids Res.23. 419-426 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tomii,K.,Kanehisa,M.: "Analysis of amino acid indices and mutation matrices for sequence comparison and structure prediction of proteins." Protein Eng.(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 高木利久: "演澤データベースのゲノム情報処理への応用" 人工知能学会誌. 10. 17-23 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mitaku,S.他: "Interaction stabilizing tertiary structure of bacteriorhodopsin studied by denaturation experiments." Proteins. 22. 350-362 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Suwa,M.,Hirokawa,T.,Mitaku,S.: "A continuum theory for the prediction of lateral and rotational positioning of α-helices in membrane proteins:Bacteriorhodopsin." Proteins. 22. 363-377 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nakaya,A.,Yamamoto,K.,and Yonezawa,A.: "RNA secondary structure prediction using highly parallel computers." CABIOS. 11. 685-692 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hagiya,M.,Miyano,S.,Nakai,K.,Suyama,A.,Yokomori,T.,Takagi,T.: "Proceedings of Genome Informatics Workshop 1995" Universal Academy Press,Inc., 179 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 美宅成樹、金久實: "ヒトゲノム計画と知識情報処理" 倍風館, 215 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ogata,H.,Akiyama,Y.and Kanehisa,M.: "A genetic algorithm based molecular modeling technique for RNA stem-loop structures." Nucleic Acids Res.23. 694-701 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Mizuno,M.and Kanehisa,M.: "Distribution profiles of GC content around the translation initiation site in different species." FEBS Lett.352. 7-10 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Uchiyama,I.,Ogiwara,A.and Kanehisa,M.: "A library of signature pentapeptides for the protein data bank." In “Protein Structures by Distance Analysis". 237-246 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Suzuki,T.,Takagi,T.,Kuhara,S.and Kanehisa,M.: "Development of an integrated database for genome mapping and nucleotide sequences." Proc. 27th Hawaii Int. Conf. on System Sciences. 5. 68-76 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Suwa,M.,Hirokawa,T.and Mitaku,S.20GB05:A continuum theory for the prediction of lateral and rotational positioning of α-helices in membrane proteins:Bacteriorhodopsin.: Proteins. (in press). (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ogasawara,N.,Nakai,S.and Yoshikawa,H.: "Systematic sequencing of the Bacillus subtilis chromosome containing the replication origin." DNA res.1. 1-14 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Miyano,S.,Akutsu,T.,Imai,H.,Gotoh,O and Takagi,T.: "Proceedings of Genome Informatics Workshop V" Universal Academy Press,Inc., 243 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ishikawa,M.,Toya,T.,Hoshida,M.,Nitta,K.,Ogiwara,A.,Kanehisa,M.: "Multiple sequence alignment by parallel simulated annealing." CABIOS. 9. 267-273 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fujibuchi,W.,Kanehisa,M.: "A method to extract functional motifs for transcriptional regulation in eukaryotic sequences." Bull.Inst.Chem.Res.,Kyoto Univ.71. 317-326 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ohkubo,Z.,Kanehisa,M.: "Characterization of spatially close peptide segments in proteins." Bull.Inst.Chem.Res.,Kyoto Univ.71. 327-337 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sakamoto,N.,Takagi,T.,Sakaki,T.: "Development of overlapping oligonucleotide database and application to signal sequence search of the human genome." CABIOS. 9. 427-434 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Satou,K.,Furuichi,E.,Takiguchi,K.,Takagi,T.,Kuhara,S.: "A deductive database system PACADE for analyzing 3-D and secondary structures of protein." CABIOS. 9. 259-266 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Suwa,M.,Mitaku,S.,Kuroda,Y.: "Theoretical analysis of amino acid sequence of human dystrophin." Biophys.Biochem.Res.Commun.191. 782-789 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takagi,T.,Imai,H.,Miyano,S.,Mitaku,S.,Kanehisa,M.: "Proceedings of Genome Informatics Workshop IV" Universal Academy Press,Inc., 465 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ogiwara,A.: "Construetion of a dicionary of sequence motifs that characterize groups of related proteins." Protein Eng.5. 479-488 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ishikawa,M.: "Multiple sequence alignment by parallel simulated annealing." Comput.Appl.Biosci.9. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Suyawa,M.: "Enzyme-reaction database to search for amino acid sequence motifa among enzymes." Comput Appl.Biosci. 9. 9-15 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Suwa,M.: "The ovetical analysis of amino acid sequence of human dystrophin." Biochem.Byophys.Res.Commun. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Dohi,H.: "Gene View:Multi-langnage human gene mapping library with graphical user interface." Comput.Appl.Biosci. 9. (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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