| Project/Area Number |
04272103
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Research Institution | University of Tokyo |
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Principal Investigator |
YOKOYAMA Shigeyuki University of Tokyo, Graduate School of Science, Professor, 大学院・理学系研究科, 教授 (00159229)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Gota University of Tokyo, Graduate School of Engineering, Lecuturer, 大学院・工学系研究科, 講師 (70211860)
OKADA Norihiro Tokyo Institute of Technology, Faculty of Bioscience and Biotechnology, Professo, 生命理工学部, 教授 (60132982)
MUTO Akira Hirosaki University, Faculty of Science, Professor, 理学部, 教授 (80034635)
WATANABE Kimitsuna University of Tokyo, Graduate School of Engineering, Professor, 大学院・工学系研究科, 教授 (00134502)
SHIMURA Yoshiro Biomolecular Engineering Research, Institute, Director, 生物分子工学研究所, 所長 (60025426)
大澤 省三 名古屋大学, 名誉教授 (10034620)
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| Project Period (FY) |
1992 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥384,100,000 (Direct Cost: ¥384,100,000)
Fiscal Year 1996: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1995: ¥33,200,000 (Direct Cost: ¥33,200,000)
Fiscal Year 1994: ¥36,000,000 (Direct Cost: ¥36,000,000)
Fiscal Year 1993: ¥35,600,000 (Direct Cost: ¥35,600,000)
Fiscal Year 1992: ¥276,300,000 (Direct Cost: ¥276,300,000)
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| Keywords | RNA / functional structure / splicing / ribozyme / ribosome / tRNA / NMR / X-ray crystallography / 高次構造 / mRNAスプライシング / rRNA / RNA触媒(リボザイム) |
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| Research Abstract |
The major results of the project for four years were presented in the 6th symposium on 24th of September, 1996. In the 6th symposium, as the results of the first "mechanism of RNA function expression", tertiary structures of RNA binding proteins involving the regulation of alternative splicing, class I aminoacyl-tRNA synthetases which perform precise tRNA recognition, and the animal mitochondrial tRNAs having characteristic secondary structures were presented. Furthermore, mechanism of activation of group I intron RNA,function of ribosomal RNA,and the molecular mimicry of tRNAs by proteins were also presented. As for the second project "investigation of new function of RNA", mechanism of trans-translation by the novel low molecular RNAs, communication mechanism between two domains in the ribosomal RNA,and function of mitochondrial RNAs on germ line maturation in Drosophila were presented. As the results of the third project "orign and evolution of RNA", the origin and evolution mechanism of aminoacyl-tRNA synthetases, ribozymes from virus, mitochondrial disease due to the mutation of mitochondrial tRNA genes were presented. These results were summarized in a printed report.
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