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Study on the relationship between environments and genetics

Research Project

Project/Area Number 04454220
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionUniversity of Tokyo

Principal Investigator

HIGURASHI Makoto  Univ.of Tokyo, Dept.of MCH, Professor, 医学部・(医), 教授 (00010223)

Co-Investigator(Kenkyū-buntansha) TAKADAYA Kumiko  Univ.of Tokyo, Dept.of MCH, Instructor, 医学部・(医), 教務職員 (20125983)
ODA Masaaki  Univ.of Tokyo, Dept.of MCH, Instructor, 医学部・(医), 助手 (20160872)
FUKUOKA Hideoki  Univ.of Tokyo, Dept.of MCH, Associate Professor, 医学部・(医), 助教授 (80111540)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1993: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1992: ¥5,000,000 (Direct Cost: ¥5,000,000)
KeywordsDown syndrome / Radiation / Recklinghausen disease / SCE / X線照射
Research Abstract

Down syndrome and Recklinghausen disease are hereditary disorders characterized by congenital malformations, and a high risk of malignancy. Cultured lymphocytes and fibroblasts from the patients with these disorders showed more chromosomal sensitivity after irradiation than do normal control subjects.
The chromosomal sensitivity to irradiation of X-ray and cell-cycle kinetics in cells form patients with Recklinghausen disease and Down syndrome.
Three cell-lines driven from the pathological region of nerve-fiber of Recklinghausen disease (6 cases) were cultured and DNA repair and unscheduled DNA synthesis (UDS) after irradiation were studied. Unscheduled DNA synthesis after irradiation between I and 4 Gy was studied, but UDS was observed in all cell-lines from neither Recklinghausen disease nor normal controls. The irradiation-study higher than 10 Gy (20, 30, 40, 100Gy) were done, but it was very bad for all cell-lines to grow.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] M.Shimada et al.: "Development of the sleep and wakefulness rhythm in preterm infants discharged from NCU" Pediat.Res.33. 159-163 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Iijima et al.: "Effects of static magnetic fields on the induction of SCE in human lymphocytes in vitro" Yamanashi Med.J.8. 9-13 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Oda et al.: "A seroimmunological analysis of Down syndrome" Genontology. 39. 16-23 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Higurashi et al.: "Ethics and fetal medicine" Jpn.J.Human Genet.38. 335-339 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Fukuoka et al.: "Cytokine production by peripheral blood mononuclear cells and metabolic turn over of bone during pregnancy" Proc.Japan Acad.69. 212-217 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Gang Ma et al.: "The development of sleep-wakefulness rhythm in normal infants and young children" Tohoku J.Exp.Med.171. 29-41 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 日暮 眞(分担): "人間の遺伝学入門" 培風館, 196 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 日暮 眞(分担): "神経疾患の遺伝学" 金原出版, 508 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Shimada, M.Higurashi, et al.: "Development of the sleep and wakefulness rhythm in preterm infants discharged from NCU" Padiat.Res.33. 159-163 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Iijima, M.Higurashi, et al.: "Effects of static magnetic fields on the induction of SCE in human lymphocytesin vitro" Yamanashi Med.J.8. 9-13 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Oda, et al.: "A seroimmunological analysis of Down syndrome" Genontology. 39. 16-23 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Higurashi, et al.: "Ethics and fetal medicine" Jpn.J.Human Genet.38. 335-339 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Fukuoka, et al.: "Cytokine production by peripheral blood mononuclear cells and metabolic turnover of bone during pregnancy" Proc.Japan Acad.69. 212-217 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Gang Ma et al.: "The development of sleep-wakefulness rhythm in normal infants and young children" Tohoku J.Exp.Med.171. 29-41 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Oda et al.: "A seroimmunological analysis of Down syndrome" Genontology. 39. 16-23 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Higurashi et al.: "Ethics and fetal medicine" Jpn.J.Human Genet.38. 335-339 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Fukuoka et al.: "Cytokine production by peripheral blood mononuclear cells and metabolic turn over of bone during pregnancy" Proc.Japan Acad.69. 212-217 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Gang Ma et al.: "The development of sleep-wakefulness rhythm in normal infants and young children" Tohoku J.Exp.Med.171. 29-41 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fukuoka,H.et al.: "Retrocaval ureter with recurrent pyelonephritis" Gynecol,Obstet.Invest.34. 57-60 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Fang-yang Wu,Takadaya,K.et al.: "Effect of phototherapy on SCE in infants with Down syndrome" Mutation Res.283. 65-67 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 日暮 眞: "ダウン症候群" Clinical Neuroscience. 10. 594-596 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Oda,M.et al.: "A sero-immunological analysis of Down syndrome" Gerontology. (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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