| Project/Area Number |
04557109
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
HAYATSU Hikoya OKAYAMA UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (10012593)
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| Co-Investigator(Kenkyū-buntansha) |
TSUIKI Hisanaga DAIWABOU CREATE,RESEARCHER, テクノステーション, 研究員
SAITOU Yutaka OKAYAMA UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (20025711)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥17,600,000 (Direct Cost: ¥17,600,000)
Fiscal Year 1994: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1993: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1992: ¥8,900,000 (Direct Cost: ¥8,900,000)
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| Keywords | MUTAGEN / DEGRADATION / Fe-OCTACARBOXYPHTHALOCYANINE / RESIN BEARING METALLOPORPHYRIN / CHLOROPHYLLIN / HETEROCYCLIC AMINE / ポルフィリン担持樹脂 / 吸着 / グリーンレーヨン / Fe^<3+>-オクタカルボキシルフタロシアニン / Trp-p-2 / cigarette smoke condensate / 金属ポルフィリン / ペルオキシダーゼ / 酸化的分解 |
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| Research Abstract |
1) Some of heterocyclic amines (Trp-P-1, Trp-P-2 and 2-amino-alpha-carboline) were degraded by the action of Fe-octacarboxyphthalocyanine-rayon(Fe-ocpc-rayon) in aqueous solutions. The presence of hydrogen peroxide in the solutions accelerated the degradation. Mutagens extracted from tabacco smoke also underwent the degradation by the Fe-ocpc-rayon.
2) IQ was converted to red colored dimer by the action of a resin bearing Mn- or Fe-tetrakis (sulfonyl) porphine ligand in the presence of hydrogen peroxide.
3) Hemin and chlorophyllin stimulated the degradation of benzo (a) pyrene-7,8-diol-9,10 epoxide, a potent carcinogenic metabolite of benzo(a)pyrene.
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