| Project/Area Number |
04557119
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human genetics
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
YOSHIDA Michihiro Hokkaido Univ. ; Fac.Sci. ; Prof., 理学部, 教授 (60001765)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Michio Flovel Inc.Software Investigator, 研究職員
UMEHARA Chizuko Hokkaido Univ. ; Fac.Sci. ; Research Assist., 理学部, 教務職員
MASUDA Ryuich Hokkaido Univ., Fac.Sci. ; Assist.Prof., 理学部, 助手 (80192748)
ABE Shuichi Hokkaido Univ., Fac.Sci. ; Assoc.Prof., 理学部, 助教授 (80125278)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 1993: ¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 1992: ¥10,300,000 (Direct Cost: ¥10,300,000)
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| Keywords | Genome / Mapping / Image analyzer / FISH / Chromosomes / In situ hybridization / プローブ / 画像処理 |
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| Research Abstract |
Development of an imaging system for chromosome analysis, particularly fluorescence in situ hybridization (FISH), is important for the human genome mapping. This research project aimed for development of an easy-and-cheap digital imaging processor for chromosome mapping :
(1) For capture FISH-metaphases as digital imaging we improved a CCD camera and software.
(2) Using the improved camera, we also developed and improved software for multicolor FISH-mapping.
Our improvements of digital imaging processors by this project have provided more rapid analysis of FISH-signals and chromosomes. However, it is necessary to do more improvement for image enhancements for clearer image and remove background distortions.
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