Genetic polymorphism of complement components in domestic animals
Project/Area Number |
04660297
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
畜産学(含草地学)
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Research Institution | Kyushu Tokai University |
Principal Investigator |
ABE Tsuneo Kyushu Tokai University, Professor School of Agriculture, 農学部, 教授 (00184218)
|
Co-Investigator(Kenkyū-buntansha) |
SHIBATA Takeshi Kyushu Tokai University, Professor School of Agriculture, 農学部, 教授 (30140958)
|
Project Period (FY) |
1992 – 1994
|
Project Status |
Completed (Fiscal Year 1994)
|
Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
Keywords | Complement / Genetic polymorphism / Immunoblotting / Domestic animals / C6 deficiency / イムノーブロッティング / 補体第6成分(C6) |
Research Abstract |
Using agarose gel isoelectric forcusing and immunoblotting with rabbit anti-rabbit C6, genetic polymorphism of the comlement component 6 (C6) was found in 6 breeds of pigs, 21 breeds or populations of dogs, 3 breeds of cattle, 1 breed of sheep and 7 breeds of horses. A genetic polymorphism of the complement component 4 (C4) was alsco found in pigs. Family data or population data indicated that C6 and C4 loci in animals were controled by several codominant alleles at a single autosomal locus, respectively. At C6 locus, 5 allels in pigs, 7 alleles in dogs, 2 allels in cattle, 2 alleles in sheep and 4 alleles in horses have been found so far. At C4 locus in pigs, 4 alleles have been found. Marked differences in gane frequencies and heterozygocities at C6 and C4 loci were observed among breeds, especially between Asian breeds and European breeds of pigs, dogs and horses, respectively. C6 deficiency in 2 of 241 pigs and 7 of 951 dogs was found, which suggested the presence of null alleles at complement loci in domestic animals.
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Report
(4 results)
Research Products
(11 results)