|Budget Amount *help
¥2,100,000 (Direct Cost : ¥2,100,000)
Fiscal Year 1994 : ¥700,000 (Direct Cost : ¥700,000)
Fiscal Year 1993 : ¥700,000 (Direct Cost : ¥700,000)
Fiscal Year 1992 : ¥700,000 (Direct Cost : ¥700,000)
Kikuchi's disease (HNL) was first reported in 1972 by Kikuchi et al. The patients with HNL represent characteristic clinical findings such as an appearance in adolescence, prefer to female, lymphadenopathy in the neck, leucopenia with a few atypical lymphocytes in the peripheral blood, fever over 38ﾟC,skin rash and spontaneous regression within two or three months and rare recurrence.
Histologically HNL demonstrates distinctive features, such as focal or partial lesions with accumulation of large transformed lymphocytes, immunoblasts, plasmacytoid monocytes, histiocytes with or without phagocytosis, and apoptotic cell in the paracortex or cortex.
The lymphocytes in the affected areas were CD8+ positive with high proliferation activity and CD4+ cells. Many of CD-4 positive cells in the affected foci are negative for T cell marker and positive for Ki Mlp as same as plasmacytoid monocytes. Apoptosis in CD4+ lymphocytes was confirmed by double staining. The same histological features are noticed in the skin and bone marrow. In the skin a proliferation of transformed lymphocytes, plasmacytoid monocytes and histiocytes with nuclear debris are found in the dermis and aggregates of plasmacytoid monocytes and histiocytes in the bone marrow which indicate the same nature of the lesion in the lymph node.
Histological and clinical features highly suggested the viral origin of the disease. Concerning the viral origin, HHV-6 genomes are found in the affected areas, but no specific gene structures were conformed. HHV-6 was found not only in HNL,but other lymphadenopathies revealed HHV-6 genomes also. The findings suggest some role of HHV-6 infection for the occurrence of the disease.