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The Stufy of the Effect of Hepatic Copper Content on Signal Intensity in Magnetic Reasonance Images

Research Project

Project/Area Number04670662
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

MATSUI Osamu  Kanazawa University, Department of Radiology, Asociatted Professor, 医学部, 助教授 (10019961)

Project Period (FY) 1992 – 1993
Project Status Completed(Fiscal Year 1993)
Budget Amount *help
¥1,400,000 (Direct Cost : ¥1,400,000)
Fiscal Year 1993 : ¥600,000 (Direct Cost : ¥600,000)
Fiscal Year 1992 : ¥800,000 (Direct Cost : ¥800,000)
KeywordsLiver / Copper / Metal / Computed Tomography / Metallothionein / Magnetic Resonace imageing / LEC rat / 銅沈着 / 肝細胞癌
Research Abstract

Effect of hepatic copper on signal intensity in magnetic resonance imaging of the liver : We analyzed the signal intensity of the liver of LEC rats, which have an abnormal copper accumulation in the liver, and of Wistar rats, and studied the correlation between signal intensity of the liver and hepatic copper content. The signal intensity of the liver of LEC rat dose not differ from that of Wistar rats on both T1 and T2 weighted images. We concluded that copper accumulation may not be responsible for the high intensity of HCCs on T1 weighted images.
Effect of copper and copper binding protein on CT attenuation value of the liver : We analyzed the effect of copper and copper binding protein on CT attenuation value in a rat model. Five Long-Evan's-cinnamon(LEC)rats, which are thought to be rat form of Wilson's disease, and 28 Wistar rats were included in this study. Wistar rats were divided into 4 groups. Five rats were normal control. In 12 rats, the common bile duct was ligated and addi … More tional copper(cupric chloride solution, daily dose of 1.8-2.4mg copper/kg)was intraperitoneally overloaded in 7 during 32-60 days. High dose copper(cupric nitrilotriacetate, daily dose of 4 mg copper/kg)was given intraperitoneally in 11 rats during 21-120 days. Hepatic copper and iron were measured by atomic absorption spectrophotometry. CT attenuation values at non-enhanced CT of the liver were examined in all rats and compare with hepatic iron and copper content, and grade of orcein positive granules that is thought to be a counter part of polymerized methalothionein in lysosome. The difference hepatic copper and attenuation value at CT was not statistically significant(correlation coefficient=0.056, p=0.96). The difference between hepatic iron content and attenuation value was statistically significant(R=0.561, p=0.007). However, CT value has a strong positive correlation with the grade of orcein positive granules(Spearman's correlation coefficient Rho=0.755, Rho corrected for ties, 0.738, p=0.0001). CT value of the liver of LEC rats did not differ from that of normal control rats. We concluded that CT attenuation value of the liver can be elevated by rich polymerized methalothionein(copper binding protein)in lysosome and has a negative correlation with hepatic copper content. Less

Report

(3results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report

Research Products

(17results)

All Other

All Publications

  • [Publications] Matsui O.et al.: "Small hepatocellular carcinoma:treatment with subsegmental transcatheter arterial embolization." Radiology. 179. 188-192 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsui O.et al.: "Enhancement of ascites on MRI following intravenous administ-ration of Gd-DTPA." Journal of Computer Assisted Tomography. 17. 617-622 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 松井修 他: "肝細胞癌に対する肝動脈化学塞栓療法6.特に塞栓物質について" 日本血管造彩Interventional Radioloqy研究会雑誌. 8. 29-36 (11993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 吉川淳,他: "肝細胞内銅および銅結合蛋白のCT値におよぼす影響-ラットにおける実験的検討-" 日本医学放射線学会雑誌. 55. 190-192 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshikawa J,Matsui(), Akimoto M,et al.: "Effect of copper and copper binding protein on CT attenuation value of the liver : Experimental study in rats." Nippon Acta Radiologica. 55. 190-192 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsui O,Takahashi S,Kadoya M,et al.: "Pseudolesion in segment IV of the liver at CT during arterial portography : correlation with aberrant gastric venous drainage." Radiology. 193. 31-35 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsui O,Kadoya M,Yoshikawa J,et al.: "Small hepatocellular carcinoma : treatment with subsegmental transcatheter arterial embolization." Radiology. 188. 79-82 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshikawa J,Matsui (), Kadoya M,et al.: "Delayd enhancement of fibrotic areas in hepatic masses : CT-pathologic correlation." JCAT. 16. 206-210 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kadoya M,Matsui O,Takashima T,et al.: "Hepatocellular carcinoma : correlation of MR imaging and histopathologic findings." Radiology. 183. 819-824 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kawamori Y,Matsui O,Kadoya M,et al.: "Differentiation of hepatocellular carcinoma from hyperplastic nodules induced in rat liver with ferrite-enhanced MR imaging." Radiology. 183. 65-72 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukui N,Kitagawa K,Matsui O,et al.: "Focal ischemic necrosis of the liver associated with cirrohosis : Radiologic findings." AJR. 159. 1021-1022 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ueda K,Matsui O,Terada T,et al.: "Vascular supply in adenomatous hyperplasia of the liver and hepatocellular carcinoma : A morphometric study." Human Pathology. 23. 619-626 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsui O.et al.: "Small hepatocellular carcinoma:tretment with subsegmental transcatheter arterial embolization." Radiology. 179. 188-192 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Matsui O.et al.: "Enhancement of ascites on MRI following intravenous administration of Gd-DTPA." Journal of Computer Assisted Tomography. 17. 617-622 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 松井修 他: "肝細胞癌に対する肝動脈化学塞栓療法 6.特に塞栓物質について" 日本血管造影Interventional Radiology研究会雑誌. 8. 29-36 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kawamori,Y.Matsui,O.,Kadoya,M.,et al: "Differentiation of hepatocellular carcinomas from hyperplastic nodules induced in rat liver with ferriteーenhanced MR imaging." Radiology. 183. 65-72 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kadoya,M.,Matsui,O.Takashima,T.: "Hepatocellular carcinoma:correlation of MR imaging and histopathologic findings." Radiology. 183. 819-825 (1992)

    • Related Report
      1992 Annual Research Report

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Published : 1992-04-01   Modified : 2016-04-21  

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