| Project/Area Number |
05045045
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | University-to-University Cooperative Research |
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ETO Kazuhiro Professor, Faculty of Dentistry Tokyo Medical and Dental University, 歯学部, 教授 (30014161)
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| Co-Investigator(Kenkyū-buntansha) |
KANOK Sorate チュラロンコン大学, 歯学部, 準教授
NARONGSAK La チュラロンコン大学, 歯学部, 講師
PIYAWAT Phan チュラロンコン大学, 歯学部, 準教授
SITTICHAI Tu チュラロンコン大学, 歯学部, 準教授
VISAKA Limwo チュラロンコン大学, 歯学部, 準教授
ISHIKAWA Isao Professor, Faculty of Dentistry Tokyo Medical and Dental University, 歯学部, 教授 (10014151)
KURODA Takayuki Professor, Faculty of Dentistry Tokyo Medical and Dental University, 歯学部, 教授 (10013939)
OHYAMA Takashi Professor, Faculty of Dentis try Tokyo Medical and Dental University, 歯学部, 教授 (50064366)
AMAGASA Teruo Professor, Faculty of Dentistry Tokyo Medical and Dental University, 歯学部, 教授 (00014332)
SORATESN Kanok Associate Professor, Faculty of Dentistry Chulalongkorn University
LAOSRISIN Narongsak Lecturer, Faculty of Dentistry Chulalongkorn University
PHANKOSOL Piyawat Associate Professor, Faculty of Dentistry Chulalongkorn University
TUDSRI Sittichai Associate Professor, Faculty of Dentistry Chulalongkorn University
LIMWONGSE Visaka Associate Professor, Faculty of Dentistry Chulalongkorn University
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1995: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Maxillofacial Surgery / Maxillofacial Prosthetics / Maxillofacial Orthodontics / Severe Periodontitis (Papillon-Lefevre Syndrome) / Maxillofacial Development and Anomalies |
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| Research Abstract |
Neural crest cells derived from forebrain and midbrain of mouse embryos were cultured separately and performed immunohistochemistry to identify the characteristics of the differentiated cells. Neurons derived from midbrain cultures were more than those from forebrain cultures. Cells which supposed to be chondrocytes were found only in midbrain cultures and melanocyte cells were observed in forebrain cultures. These results mean that the differential potentialities from the both regions seemed to be partly restricted before migrating out from the neuroepithelium.
The severe maxillofacial disorders related to the surgery were investigated in two medical facilities and the data during the past 10 years was compared each other. The largest group in malignant tumors was represented by squamous cell carcinoma and more than 40% occurred on the mandible in Thailand and on the tongue in Japan. Of all benign tumors ameloblastoma (51.4%) made the largest group in Thailand and hemangioma (18.8%) in
… More
Japan. Unilateral cleft lip and palate was the most frequent malformation in both countries. In the data of the maxillofacial fractures men were almost 3 times as many as women. The fractures were caused mainly by traffic accident (72.5%) in Thailand and by fall down (30.0%) in Japan. Concerning TMJ dysfunction ankylosis (87.5%) and condylar hyperplasia (12.5%) were treated surgically in Thailand.Depending on the pathologic conditions several surgical procedures applied in Japan.
A clinico-statistical study was performed on patients with severe maxillofacial disorders in Thailand and Japan. Data on the patients and maxillofacial prosthetic cares for them were compared between the two, conspicuous difference was found in many respects that mainly based on the economic status of the nation.
A comparative cephalometric study was carried out by using pre- and post surgical orthodontic treatment in both institute. There were 21 cephalometric parameters used in this study. Some similarities in both samples were found, however, a few differences were also recognized. More lingually inclined lower incisor and more increased anterior dental height were found in Thai patient after treatment.
Papillon-Lefevre syndrome (PLS) patients were examined and treated. The ELISA titers of the patients against Actinobacillus actinomycetemcomitans (A.a.) decreased after treatment and A.a.could not be detected in bacterial cultures. PLS patients showed positive antibody response to the same antigens of A.a.A.a.seemed to play role to periodontal tissue destruction in PLS patients. Less
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