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Pathological and Preventive Nutritional Studies on Environmental Factors of Cerebrovascular Dementia in the Japanese, from Neutritional Pathogenesis of Cerebrovascular Diseases.

Research Project

Project/Area Number 05304050
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 環境影響評価(含放射線生物学)
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

YAMORI Yukio  Professor, Graduate School of Human and Environmental Studies, Kyoto University, 大学院・人間・環境学研究科, 教授 (80025600)

Co-Investigator(Kenkyū-buntansha) HORIE Ryoichi  Assistant Professor, Department of Pathology, Shimane Medical University, 医学部, 助教授 (60127529)
SUNAGA Toshiaki  Professor, Department of Medicine, Saga Medical School, 医学部, 教授 (40013916)
NUMANO Fujio  Professor, School of Medicine, Tokyo Medical and Dental University, 医学部, 教授 (40013958)
YOSHIDA Yoji  Professor, Department of Medicine, Yamanashi Medical University, 医学部, 教授 (10008237)
YATANI Ryuuichi  Professor, Faculty of Medicine, Mie University, 医学部, 教授 (80024636)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1994: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsStroke / Cerebrovascular Dementia / Immunohostochemistry / Perforating Arteries / Angionecrosis / Phagocytos / Actin / Monoclonal Antibody / モノクロープル抗体
Research Abstract

We studied the pathogenetic feature of cerebrovascular diseases by applying new immunohistochemical techniques according to the well-standardized study protocol among collaborating investigators : Brain specimens (1*1*0.5cm)including perforating and cortical arteries from autopsied cases of stroke and/or cerebrovascular dementia were obtained within 5 hours after death were fixed in methonal-Carnoy's fixative, embedded in paraffin and sectioned for routine pathalogical examination after Hematoxilin, Eosin, Masson, Azan-Mallory and Elastica van Gieson stains as well as for immunoperoxidase staining, using monoclonal antibodies against antiactin and antimacrophage antibodies.We demonstrated the degeneration and necrosis started at the outer layr of smooth muscle cells of perforating arteries with the infiltration of macrophages from Virchow-Robin's space and collagen proliferation, and at the advanced stage macrophages penetrated through endothelial cells and accumulated in the subendothelial space to induce occlusive lesions like vascular lesions in stroke-prone SHR.These findings support the importance of disturbance in the pathogenesis of cerebrovascular diseases in stroke and cerebrovascular dementia in the Japanese.This aspect was also supported by our comparative epidemiological survey on the nutrition of Japanese immigrants who had less incidence of stroke than the Japanese in Japan.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Tagami,M.,Tsukada,T.,Kubota,A,Nara,Y.,Yamori,Y.: "Immunocytochemical study of cerebral perforating arteries in patients with cerebral infarctions." Acta Histochem.Cytochem.26. 109-115 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 家森幸男: "微量元素と神経疾患-高血圧・脳卒中" Clinical Neuroscience別冊. 12. 204-207 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 家森幸男: "栄養改善と成人病予防-循環器疾患予防に関する実験病理と国際疫学研究の成果-" Nano Giga. 3. 200-205 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 水嶋春朔、上田真由美、沢村誠、奈良安雄、家森幸男: "ハワイ日系移住者における栄養と循環器疾患リスクファクター" 第4回日本疫学会総会講演集. 3047- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamori,Y.,Nara,Y.,Mizushima,S.,Sawamura,M.,Horie,R.: "Nutritional factors for stroke and major cardiovascular diseases:International epidemiological comparison of dietary" Health Reports. 6. 22-27 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 家森幸男、水嶋春朔、沢村誠、奈良安雄: "高血圧、主要循環器疾患の栄養因子-食事による予防のための国際比較研究" Deutsche Medizinische Wochenschrift. 15. 1825-1841 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamori,Y.: "The Third International Conference on Nutrition in Cardiocerebrovascular Diseases" Annals of the New York Academy of Sciences, 370 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 家森幸男、A.ハワード、G.キンスマン、奈良安雄、沢村誠、水嶋春朔26HB02:東京医学社: "臨床成人病" 127 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tagami,M.,Tsukada,T.,Kubota,A.,Nara,Y.,Yamori,Y.: "Immunocytochemical study of cerebral perforating arteries in patients with cerebral infarctions." Acta Histochem.Cytochem.26. 109-115 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 家森幸男: "微量元素と神経疾患-高血圧・脳卒中" Clinical Neuroscience別冊. 12. 204-207 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 家森幸男: "栄養改善と成人病予防-循環器疾患予防に関する実験病理と国際疫学研究の成果-" Nano Giga. 3. 200-205 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 水嶋春朔、上田真由美、沢村誠、奈良安雄、家森幸男: "ハワイ日系移住者における栄養と循環器疾患リスクファクター" 第4回日本疫学会総会講演集. 3047- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamori,Y.,Nara,Y.,Mizushima,S.,Sawamura,M.,Horie,R.: "Nutritional factors for stroke and major cardiovascular diseases:International epidemiological comparison of dietary" Health Reports. 6. 22-27 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 家森幸男、水嶋春朔、沢村誠、奈良安雄: "高血圧、主要循環器疾患の栄養因子-食事による予防のための国際比較研究" Deutsche Medizinische Wochenschrift. 15. 1825-1841 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamori,Y.: "The Third International Conference on Nutrition in Cardiocerebrovascular Diseases" Annals of the New York Academy of Sciences, (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 家森幸男、A.ハワード、G.キンスマン,奈良安雄、沢村誠、水嶋春朔: "臨床成人病" 東京医学社, (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tagami,M.,Tsukada,T.,Kubota,A.,Nara,Y.,Yamori,Y.: "Immunocytochemical study of cerebral perforating arteries in patients with cerebral infarctions." Acta Histochem.Cytochem.26. 109-115 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yamori,Y.: "Hypertensive Cerebrovascular Diseases:Importance of Nutrition in Pathogenesis and Prevention.(Series:Annals of the New York Academy of Sciences 676)In“The Third International Conference on Nutrition In Cardio-Cerebrovascular Diseases"" York Acad.Sci.,New York(Lee,K.T.,Oike,Y.& Kanazawa,T.,eds.), 370(92-104) (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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