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A new the rapy with oligosaccharide against inflammatory bowel dis eases

Research Project

Project/Area Number 05454362
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionWakayama Medical School

Principal Investigator

TANIMURA Hiroshi  Wakayam Medical School, Gastroenterological Surgery, Proffesor, 医学部, 教授 (10026990)

Co-Investigator(Kenkyū-buntansha) UCHIYAMA Kazuhisa  Wakayam Medical School, Gastroenterological Surgery, 医学部, 講師 (80232867)
ISHIMOTO Kiwao  Wakayam Medical School, Gastroenterological Surgery, Assistant Proffesor, 医学部, 助教授 (40176227)
OCHIAI Minoru  Wakayam Medical School, Gastroenterological Surgery
TUJI Takeshi  Wakayam Medical School, Gastroenterological Surgery
IWAHASHI Makoto  Wakayam Medical School, Gastroenterological Surgery
岩橋 誠  和歌山県立医科大学, 医学部, 助手 (70244738)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1993: ¥4,300,000 (Direct Cost: ¥4,300,000)
Keywordsoligosaccharide / Bifidobacterium / Short-chain fatty acids / fiber / ulcerative colitis / inflammatory bowel disease / hutyiate / propionate / 過病性大腸炎 / ビヒイズス菌 / ビヒィズス菌
Research Abstract

We reported that administration of Fructo-oligosaccharide (FOS) increased the concentration of short-chain fatty acids (SCFA) in the feces of the rats with experimental ulcerative colitis induced by 5% dextran sodium sulfate (DSS) in water.
Herein, we examined the improvement of acute experimental colitis induced by DSS and compared the values of SCFA,the number of intestinal becteria between the three group of rats given a) 10% FOS,b) 15% cellulose containig food, c) non-fiber food for a week.
Administration of FOS resulted in the most rapid improvement as evaluated from the number of Bifidobacterium, the comcentration of SCFA,and the pathological inflammation of the colon in rats.
Then, we administered 30g FOS/day with the elemental diet (ED) to humans with inflammatory bowel diseases.
Administration of FOS with ED resulted in the increase of the prealbumin level, and body weight in a Crohn's disease patient and we found that the administration of FOS resulted in an improvement ; the unmber of Bifidobacterium and Lactobatilus increased, that of Clostridium decreased and the concentration of SCFA increased in the patients with inflammatory bowel diseases.
In conclusion, administration of FOS resulted in the improvement the colonic environment not only in rats with experimental ulcerative colitis, but also in patients with bowel diseases.
FOS might be useful as a new therapy against inflammatory bowel diseases.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 谷村弘,ほか.: "臨床医からみた経腸栄養法の合併症対策について" 栄養一評価と治療. 10. 436-438 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 正木 和人,ほか: "食物繊維がDMH誘発大腸癌の発生部位と組織型に及ばす影響" 消化器癌の発生と進展. 5. 293-296 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 梅本善哉,ほか.: "潰瘍性大腸炎の治療における食物繊維の意義についての実験的検討" 日本静脈経腸栄養研究会誌. 8. 112-115 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 梅本善哉,ほか.: "実験的潰瘍性大腸炎におけるフラクトオリゴ糖の腸内環境改善作用について" 消化と吸収. 16. 84-87 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 梅本善哉,ほか.: "潰瘍性大腸炎モデルおよび炎症性腸疾患に対するオリゴ糖治療の試み" 消化と吸収. 17. 48-53 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 谷村 弘: "臨床栄養学" 南江堂, 11 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 谷村 弘: "癌患者の栄養管理" メディカル レビュー社, 11 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 谷村 弘、ほか: "第30回日本外科代謝栄養学会シンポニウムのまとめ" 外科と代謝・栄養. 27(6). 501-502 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 谷村 弘、ほか: "臨床医からみた経腸栄養法の合併症対策について" 栄養評価と治療. 10(4). 436-438 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 梅本善哉、谷村弘ほか: "潰瘍性大腸炎の治療における食物繊維の意義についての実験的概論" 日本静脈・経腸栄養研究会誌. 第8巻. 112-115 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 梅本善哉、谷村弘ほか: "潰瘍性大腸炎モデルおよび炎症性腸疾患に対するオリゴ糖治療" 消火と吸収. 17(1). 48-53 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 谷村 弘: "「臨床栄養学」第2版" 南江堂, 11 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 谷村 弘、ほか: "癌患者の栄養補給" メデイカルレビュー社, 8 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 谷村 弘,他: "潰瘍性大腸炎の治療における食物繊維の意義についての実験的検討" 日本静脈・経腸栄養研究会誌. 第8巻. 112-115 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 谷村 弘,他: "実験的潰瘍性大腸炎におけるフラクトオリゴ糖の腸内環境改善作用について" 消化と吸収. 第16巻. 84-89 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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