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Molecular mechanism of the region-specific neural connection in the retino-tectal system.

Research Project

Project/Area Number05454662
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionOkazaki National Research Institutes, National Institute for Basic Biology

Principal Investigator

NODA Masaharu  Okazaki National Research Institutes, National Institute for Basic Biology Division of Molecular Neurobilogy Professor, 基礎生物学研究所, 教授 (60172798)

Project Period (FY) 1993 – 1995
Project Status Completed(Fiscal Year 1995)
Budget Amount *help
¥4,900,000 (Direct Cost : ¥4,900,000)
Fiscal Year 1995 : ¥1,100,000 (Direct Cost : ¥1,100,000)
Fiscal Year 1994 : ¥1,200,000 (Direct Cost : ¥1,200,000)
Fiscal Year 1993 : ¥2,600,000 (Direct Cost : ¥2,600,000)
Keywordsretina / tectum / neural connection / retrovirus vector / subtraction / レトロウィルスベクター / PCR
Research Abstract

Topographic maps of neuronal connectivity have been reported for various parts of the nervous system. In the visual system of birds, retinal ganglion cell axons from the nasal (anterior) retina connect to a caudal (posterior) part of the midbrain visual center, the optic tectum and temporal (posterior) retinal axons connect to the rostral (anterior) part, thereby establishing a point-to-point projection map. To elucidate the molecules required for construction of this map, we applied a subtractive hybridization technique, and found several genes (one from nasal, four from temporal) to be topographically expressed along the naso-temporal axis in the embryonic chicken retina. Among these position-specific molecules, two transcriptional regulators which belong to the winged-helix family are expressed in a mutually exclusive manner in either the nasal or temporal part of the retina. Misexpression of each factor in the retina using a retroviral vector causes misprojection on the tectum along the rostro-caudal axis. Our results provide direct evidence that topographic expression of these transcription factors controls formation of the topographic map for retinotectal connectivity. We are expecting to reveal the molecular bases of the specific neural connection in the retinotectal projection through investigation of the gene cascade starting from these two transcription factors.

Report

(4results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report

Research Products

(3results)

All Other

All Publications

  • [Publications] 湯浅純一、平野伸二、山形方人、野田昌晴: "Visual projection map specified by topographic expression of transcrition factors in the retina." nature. 382. 632-635 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 山形方人、野田昌晴: "細胞工学" 秀潤社, 10 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Junichi Yuasa, Shinji Hirano, Masahito Yamagata, Masaharu Noda: ""Visual projection map specified by topographic expression of transcription factors in the retina."" Nature. 382. 632-635 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary

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Published : 1993-04-01   Modified : 2016-04-21  

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