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Physiological role of the ascending monoaminergic system in hypothalamo-hypophysial responses to emotional stress

Research Project

Project/Area Number 05454675
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionJichi Medical School

Principal Investigator

YAGI Kinji  Department of Physiology, Jichi Medical School, Professor, 医学部, 教授 (70048974)

Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1995: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1993: ¥3,400,000 (Direct Cost: ¥3,400,000)
KeywordsVasopressin / Fear stress / Anxiety stress / Dopamine / Histamine / Noradrenaline / Benzodiazepine / Serotonin / オキシトシン / ノルアドレナリンニューロン / セロトニンニューロン / 侵害刺激 / ラット / ノルアドレナリン神経 / 情動記憶 / ストレス / ヒスタミン受容体 / 新奇性ストレス / パゾプレシン / 学習・記憶
Research Abstract

Effects of monoaminergic receptor antagonists or a benzodiazepine were studied on neuroendocrine responses to fear stimuli of anxiety-producing novel stimuli in male Wistar rats.
1.Dopaminergic D1 receptors were found to mediate facilitatory vasopressin response to noxious stimuli but not the suppressive vasopressin response to conditioned fear stimuli.
2.Anxiogenic novel environmental stimuli were shown to suppress vasopressin secretion.
3.Histaminergic H2 receptors were shown to mediate the suppressive vasopressin response to novel stimuli and to inhibit, in an activity-dependent manner, the facilitatory oxytocin response to the stimuli.
4.The noradrenergic system was demonstrated to mediate the responses in vasopressin, oxytocin and prolactin secretion to conditioned fear stimuli but not to the responses to unconditioned fear stimuli or anxiogenic novel environmental stimuli.
5.Chlordiazepoxide, one of the benzodiazepines which are known to ameliorate an anxiety state as a result of modulating noradrenergic neuron activity, was found to block the responses in vasopressin and oxytocin secretion to unconditioned or conditioned fear stimuli but not the responses to anxiety-producing novel environmental stimuli.
6.Serotonergic 5-HT_<1A> receptors were demonstrated to be involved in the vasopressin and oxytocin responses to conditioned fear stimuli but not to novel stimuli.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Yagi,K: "Effects of a histamine H2-receptor antagonist,ranitdine on the vasopressin and oxytocin responses to novelty stress in the rat." Neurosci Res. 19. 357-364 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagi,K: "Suppressive vasopressin reponse to emotional stress and the neuroactive substances involved (in Japanese)" Brain Sci Mental Disorders. 5. 127-136 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagi,K and Onaka,T: "Chlordiazepoxide discriminates between the neural circuits mediating neuroendocrine responses to fear-and anxiety-producing stimuli in the rat." Neurosci Res. 24. 151-158 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagi,K and Onaka,T: "A benzodiazepine,chlordiazepoxide,blocks vasopressin and oxytocin release after footshocks but not osmotic stmulus in the rat." Neurosci Letters. 203. 49-52 (1966)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Onaka,T and Yagi,K: "Norepinephrine deletion impairs neuroendocrine responses to fear not novel environmental stimuli in the rat." Brain Res. in the press. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Onaka,T and Yagi,K: "A selective role of brainstem noradrenergic neurons in oxytocin release from the neurohypophysis following noxious stimuli in the rat." Neurosci Res. in the press. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagi, K and Onaka, T: "Suppressive vasopressin response to emotional stress : the neuroactive substance that may be involved." Ann NY Acad Sci. 689. 685-688 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Onaka T and Yagi, K: "Effects of novelty stress on vasopressin and oxytocin secretion by the pituitary in the rat." J Neuroendocrinol. 5. 365-369 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagi, K: "Effects of a histamine H2-receptor antagonist, ranitidine on the vasopressin and oxytocin responses to novelty stress in the rat." Neurosci Res. 19. 357-364 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagi, K: "Suppressive vasopressin response to emotional stress and the neuroactive substances involved" Brain Sci Mental Disorders. 5 (in Japanese). 127-136 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagi, K and Onaka, T: "Chlordiazepoxide discriminates between the neural circuits mediating neuroendocrine responses to fear- and anxiety-producing stimuli in the rat." Neurosci Res. 24. 151-158 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagi, K and Onaka, T: "A benzodiazepine, chlordiazepoxide, blocks vasopressin and oxytocin release after footshocks but not osmotic stimulus in the rat." Neurosci Letters. 203. 49-52 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Onaka, T and Yagi, K: "Norepinephrine deletion impairs neuroendocrine responses to fear but not novel environmental stimuli in the rat." Brain Res. (in the press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Onaka, T and Yagi, K: "A selective role of brainstem noradrenergic neurons in oxytocin release from the neurohypophysis following noxious stimuli in the rat." Neurosci Res. (in the press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagi, K. et al.: "Chlordiazepoxide discriminates between the neural cercuits mediating neuroendocrine responses to fear- and anxiety-producing stimuili in the rat." Neuroscience Research. 24. 151-158 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yagi, K. et al.: "A bensodiazepine, chlordiazepoxide, blocks vasopressin and oxytocin release after footshocks but not osmotic stimulus in the rat." Neuroscience Letters. 203. 49-52 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Onaka, T. et al.: "Norepinephrine deplation impairs neuroendocrine responses to fear but not novel environmental stimuli in the rat." Brain Research. (印刷中). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Onaka, T. et al.: "A selective role of brainstem noradrenergic neurons in oxytocin release from the neurohypophysis following noxious stimuli in the rat." Neuroscience Research. (印刷中). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kinji Yagi: "Effects of a histamine H2-receptor antagonist,ranitidine on the vasopressin and oxytocin responses to novelty stress in the rat." Neurosci.Res.19. 357-364 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 尾仲達史: "ストレスの生理反応" Mebio. 11. 16-22 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 八木欽治: "神経内分泌系の情動ストレス反応とこれに関与する神経活性物質" 脳と精神の医学. 5. 127-136 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 八木欽治(訳): "情動・記憶と脳" 日経サイエンス. 24. 58-69 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kinji Yagi: "Chlordiazepoxide blocks neurohypophysial responses to fear stress but not those to novelty stress in the rat." Jpn.J.Physiol.44Suppl.1. S269 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kinji Yagi: "Differential vasopressin responses to physical or emotional stress." Abstracts of the Third Congress of FAOPS. 122 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kinji Yagi: "Differential effects of chlordiazepoxide on the suppressive vasopressin response to fear or novelty stress." Abstracts of Novel Facts in Neuroendocrinology. 19-20 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tatsushi Onaka: "Effects of noradrenaline depletion upon suppressive vasopressin responses to fear-related stimuli in rats." Neurosci.Res.Suppl.19. S256 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kinji Yagi: "Chlordiazepoxide blocks the augmentative vasopressin response to physical stress but not the supressive response to fear stress." Neurosci.Res.Suppl.19. S256 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 八木欽治: "バゾプレシンの情動ストレス反応に対するベンゾジアゼピンの選択的阻害作用" 日本内分泌学会雑誌. 70. 213 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 八木欽治: "バゾプレシン分泌におけるストレス反応" 第21回日本脳研究会抄録. 30-31 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Onaka,T.: "Effects of novelty stress on vasopressin Dxytocinytocin secretion by the pituitary in the rat." J.Neuroendocrinol.5. 365-369 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yagi,K.: "Suppressive Vasopressin response to emotional stress:the neuroactive substance that may be involved." The Annals of the New York Academy of Sciences.689. 685-688 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yagi,K.: "A histamine H_2-receptor antagonist,ranitidine,blocks the suppressive vasopressin response to novelty stress in the rat." Jpn.J.Physiol.Suppl.2. 43. S291- (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yagi,K.: "Vasopressin and oxytocin rosponses to novelty stress in the rat and the selective effect of a histaminergic H2-receptor antagonist." Abstracts of xxxll IUPS Congress. 240- (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yagi,K.: "Effects of chiordiazepoxide on the associatively Acquired Vasoppessin and oxytocin respondes to tear-related emotional stress in the rat." Neurosci.Res.Suppl.18. S97- (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yagi,K.: "Effects of histamine H2-receptor antagonist,ranitidine on the vasopressin and oxytocin responses to novelty stress in the rat." Neurosci.Res.(印刷中). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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