| Project/Area Number |
05556019
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Gifu University |
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Principal Investigator |
KISO Makoto Gifu University, Professor, 農学部, 教授 (90092931)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKUNI Yoshiaki Nippon Shinyaku Co.Ltd., Head of Research Labo., 生物研究所, 部長
ISHIDA Hideharu Gifu University, Assoc.Professor, 農学部, 助教授 (20203002)
HASEGAWA Akira Gifu University, Professor, 農学部, 教授 (10026429)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥6,600,000 (Direct Cost: ¥6,600,000)
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| Keywords | 1-deoxynojirimycin / cell adhesion inhibitor / sialyl-Lewis X oligosaccharide / sialyl-Lewis A oligosaccharide / sulfo-Lewis X oligosaccharide / sulfo-Lewis A oligosaccharide / 1-デオキシノジリマイシン / セレクチン結合阻害剤 / 糖鎖医薬品 / N-アルキル-1-デオキシノジリマイシン / シアリルオリゴサッカライド / シアリルルイス X / シアリルルイス A / N-メチル-1-デオキシノジリマイシン / シアロ糖鎖 / シアリルルイスX / シアリルルイスA / セレクチン |
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| Research Abstract |
We have examined the recognition specificity of sialooligosaccharides by influenza virus and leukocyte cell adhesion molecules (selectin family) at the molecular level. As a results, it has been shown that 1) sialyl paragloboside is one of the best substrate for influenza virus recognition, and 2) both sialyl-Lewis X and sialyl-Lewis A can be well recognized by all selectins. It was also found that sulfo-Lewis X and sulfo-Lewis A function as the selectin ligands with the equal or more afinity than the corresponding sialyl derivatives.
Based on these results, a variety of novel oligosaccharides containing 1-deoxynojirimycin have been synthesized as the inhibitors of virus infection and selectin binding. Some of the N-alkyl-1-deoxynojirimycin-containing sialyl-and sulfo-Lewis X and -Lewis A epitope analogs have been found to be potent anti-inflammatory agents by using the animal models. A wide therapeutic application of these compounds is now in progress.
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