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Localized NMR spectroscopy and functional mapping of the brain.

Research Project

Project/Area Number 05558098
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionOita Medical University

Principal Investigator

YAMADA Kazuhiro  Oita Med.Univ., Physiol., Prof., 医学部, 教授 (20053027)

Co-Investigator(Kenkyū-buntansha) IRIGUCHI Norio  Siemens Asahi Medical Systems Ltd.MD Application Dept., Assistant Manager, 次長(NMR開発)
NISHIMARU Naoko  Oita Med.Univ., Physiol., Assistant Prof., 医学部, 助手 (60101086)
HORI Shigeaki  Oita Med.Univ., Neurosurgery., Prof., 医学部, 教授 (00004987)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1993: ¥3,600,000 (Direct Cost: ¥3,600,000)
Keywordsmagnetic resonance spectroscopy / laser doppler flowmetry / regional lactate / regional blood flow / rabbit brain / hypoxia / oxygen delivery / 筋肉 / 脳 / 非侵襲的方法 / 脳の局在機能 / Nアセチルアスパラギン酸 / 低酸素
Research Abstract

Simultaneous applications of localized proton magnetic resonance spectroscopy (1H-MRS) and laser doppler flowmetry (LDF) allowed us to observe concurrent changes in regional lactate level and regional blood flow (rBF) in the anesthetized rabbit brain. The voxel (8mm-cubic) for 1H-MRS was located mostly in the thalamic area, and the rBF was recorded in the same area contralaterally. The localization in the 1H-MRS was assessed by using a phantom model and was proved to be practically satisfactory. During hypoxia, lactate increased gradually, while the rBF increased rapidly. Despite the increase in rBF,the oxygen delivery, which was the oxygen content in arterial blood (O2 CT) multiplied by the rBF,decreased. There was a linear correlation between the increase in lactate in last ten minutes during the thirty minutes hypoxia and deficiency in the oxygen delivery during hypoxia (correlation coefficience ; r2=0.68, n=14, P<0.001). In the subsequent recovery period, the rBF decreased slowly, while the O2 CT increased rapidly back to the control level. This rate of rFB recovery after hypoxia was linearly correlated with the increase in lactate (partial correlation coefficience ; r2=0.72, n=14, p<0.001).

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Yanai,S.: "Accumulation of intracellular lactate induces on in crease in oxygen delivery during recovery from hypoxia." Fourth IBRO World Congress of Neurosciences. Abstracts :. P151-B1.6 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yanai,S.: "Concurrent measurements of oxygen delivery and lactate production in rabbit thalamus." Neurosci Res. Sup 19. S152- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yanai,S.: "Concurrent measurement of regional cerebral blood flow and metabolism using laser doppler flowmetry and volume selected NMR spectroscopy" Jpn J Physiol. 44. S260- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yanai S,Nishimaru N,Soeda T,Yamada K: "Accumulation of intracellular lactate induces an increase in oxygen delivery during recovery from hypoxia." Fourth IBRO world congress of neuroscience.(Abstr.). 151. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yanai S,Nishimaru N,Soeda T,Yamada K: "Concurrent measurements of oxygen delivery and lactate production in rabbit thalamus." Neurosci Res (Abstr.). Suppl 19. S152 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yanai S,Nishimaru N,Soeda T,Yamada K: "Concurrent measurement of regional cerebral blood flow and metabolism using laser doppler flowmetry and volume selected NMR spectroscopy." Jpn J Physiol (Abstr.). 44. S260 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yanai,S.: "Accumulation of intracellular lactate induces on increase in oxygen delivery during recovery from hypoxia." Fourth IBRO World Congress of Neurosciences. Abstracts :. P151-B1.6 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] S.Yanai,N.Nisimaru,T.Soeda,K.Yamada: "Concurrent measurments of regional cerebral blood flow and metabolism using laser duppler flowmetry and volume selected NMR spectroscopy during hypoxia." Japanese Journal of Physiology,Proceedings of the Annual. Suppl.44. S260 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.Yanai,N.Nisimaru,T.Soeda,K.Yamada: "Condurrent measurments of oxygen delivery and lactate production in rabbit thalamus." Neurosci.Res.Suppl.19. 1325 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 山田和廣、柳井荘緑: "核磁気共鳴による脳機能の評価" 基礎老化研究. (印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.Yanai, N.Nisimaru, K.Yamada: "Localized proton spectroscopy of rabbit brain-efects of hypoxia." Japanese Journal of Physiology,Proceedings of the Annual Meeting.(1994). (in press). (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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