| Project/Area Number |
05671371
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Okayama University |
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Principal Investigator |
KUDO Takafumi Okayama University, Medical Department, Professor, 医学部, 教授 (90127556)
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| Co-Investigator(Kenkyū-buntansha) |
TADA Katsuhiko Okayama University, Medical Department, Assistant, 医学部附属病院, 助手 (90252973)
KISHIMOTO Yasuo Okayama University, Medical Department, Assistant Professor, 医学部附属病院, 講師 (30186217)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Fetal lung / Catecholamine / Dopamine / Dopa decarboxylase / Growth-retarded fetus / Chronic fetal hypoxia / Fetal stress / 胎仔肺機能 / 胎児慢性低酸素症 / ドパミン受容体 |
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| Research Abstract |
Catecholamine (CA) synthetic capacity in fetal rat lung was cxamined on Day 20 of gestation. Three common CAs were present in the fetal rat lung. But their proportions differed from those in the adrenal gland, brain, blood, and amniotic fluid. To confirm the capacity of the fetal rat lung to synthesize CA,L-dopa was injected into pregnant rats, and CAs in the lungs of the fetuses of these rats were measured. The concentrations of all three CAs were increased significantly as compared with those in the lungs of fetuses from control rats. Immunohistochemical technique served to localize the CA synthetic enzyme, aromatic-L-amino acid decarboxylase, in the lung. The concentration of CAs in the lungs of growth-retarded rat fetuses prepared by the Wigglesworth method was higher than in the lungs of normal fetuses. Thus, it appeared that CAs exist in the fetal rat lung, and that fetal lung can synthesize all CAs. Findings in growth-retarded fetuses suggest that CA content in the fetal lung may be altered under conditions of chronic hypoxia.
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