|Budget Amount *help
¥1,900,000 (Direct Cost : ¥1,900,000)
Fiscal Year 1994 : ¥900,000 (Direct Cost : ¥900,000)
Fiscal Year 1993 : ¥1,000,000 (Direct Cost : ¥1,000,000)
This research could be devided into two parts. One of the parts is the relationship between gingivitis and microflora associated with periodontal diseasei in Down's Syndrome (DS), and one of the parts is the relationships in normal children. In Down's Syndrome, sera were obtained from 75 subjects (ages 2 to 18 years) selected from a population of DS.The gingival health of these subjects was scored by a modified PMA Index (MT-PMAI). Antibody titers to Porphyromonus gingivalis (Pg), Prevotella intemedia (Pi), Treponema denticola (Td), Fusobacterium nucleatum (Fn), Selemonas sputigena (Sel), Actinobacillus Actinomycetemcomitans (Aa), and Streptococcus mitis (Mi)were determined using the micro ELISA.The findings of this study suggested that colonization by Fn and Aa are closely associated with the onset and severity of gingivitis in DS patients under five years old. On the other hand, the colonization by Pg, Sel and Mi appear to be associated with gingivitis at puberty in DS patients. In the normal children, sera were obtained from 40 subjects (ages 2 to 18 years) selected from a population of normal children. The findings of this study suggested that colonization by Aa are closely associated with the onset and severity of gingivitis in normal children under seven years old. On the other hand, the colonization by Pg appear to be associated with gingivitis at puberty in normal children. Therefore, this studies indicated that Aa is the most important microflora for parameter in order to the prevention of periodontal disease in childhood, and that colonization by Pg are closely associated with the onset and severity of periodontal disease form puberty.