PEDRO A Reye 国立循環器研究所(メキシコ), 教授
FRANK C Arne メディカルスクール, 医学部, 教授
YACOV Itzcha カイム, シバ・メディカルセンター・医学部, 教授
N.K Mehra 全インド医科学研究所, 教授
B.K Sharma チャディングラ大学, 研究所, 教授
NITAYA Suwan チュラロンコーン大学, 医学部, 教授
Y.B Park ソウル大学, 医学部, 助教授
角田 恒和 東京医科歯科大学, 医学部, 助手 (30262190)
長沢 俊彦 杏林大学, 医学部, 教授 (00086505)
西村 泰治 熊本大学, 医学部, 教授 (10156119)
GRANDOS Juli 国立循環器研究所, 助教授
PARK Y.B ソウル大学, 医学部, 助教授
HOFFMAN Gray クリーブランドクリニック(オハイオ州立大学), 教授
REYESーLOPEZ 国立循環器研究所(メキシコ), 教授
ROSENTHAL Ta カイム, シバ・メディカルセンター・医学部, 教授
ARNETT Frank メディカルスクール, 医学部, 教授
MECHRA N.K. 全インド医科学, 研究所, 教授
SHARMA B.K. Postraduate Institute of Medical Education and Research, Professor, 研究所, 教授
PREEYACHIL C チュラロンコーン大学, 医学部, 助教授
SUWANWELA Ni チュラロンコーン大学, 医学部, 教授
能勢 真人 東北大学, 医学部, 助教授 (70030913)
松原 修 防衛医科大学校, 医学部, 教授 (40107248)
木村 彰方 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
MEHRA N.K. All India Institute of Medical Sciences, Professor
CHARAOENWONGSE P. Chulalongkorn University, Associate Prof.
SUWANWELA N. Chulalongkorn University, Professor
KAKUTA Tsunekazu Tokyo Med.& Dent.University, Assistant Prof.
NOSE Masato Tohoku University, Associate Professor
KIMURA Akinori Tokyo Med.& Dent.University, Professor
MATSUBARA Osamu National Defefense Medical College, Professor
NISHIMURA Yasuharu Kumamoto University, Professor
NAGASAWA Toshihiko Kyorin University, Professor
PARK Y.B. Seoul National University Hospital, Prof.
ARNETT F.C. The Univ.of Texas, Professor
HOFFMAN G.S. Cleveland Clinic Foundation, Professor
REYES-ROPEZ P.A. Instituto Nacional de Cardiologia, Prof.
GRANDOSE J. Instituto Nacional de Cardiologia, Associate Prof.
ROSENTHAL Talma The Chaim Sheba Medical Center, Professor
|Budget Amount *help
¥17,300,000 (Direct Cost : ¥17,300,000)
Fiscal Year 1995 : ¥8,400,000 (Direct Cost : ¥8,400,000)
Fiscal Year 1994 : ¥8,900,000 (Direct Cost : ¥8,900,000)
Takayasu arteritis is a chronic vasculitis involving mainly the aorta and its main branches, the cause of which is still in the mist and Japanese government nominated this morbid condition as one of the incurable disease to take care of patients.
Recent studies, however, have been veiling up this morbid condition, among which the genetic factor (s) have been especially focussed as the key of its etiology because species differences is known to be one of its characteristic features. Our population and family studes on HLA typing in patient with Takayasu arteritis revealed a closed linkage with an haplotype of A 24-B52-DR2 and clinical features were confirmed to be intimately related to this haplotype.
The international comparative studies of Takayasu arteritis revealed a close association with B-5 or B52 in Korean. Indian and Mexican patients. At the same time, in this international conference, another characteristics has been interested. In Japan, many patients have been involved in asce
nding aorta and/or aortic arch causing the characteristic clinical features of pulselessness, oph thalmic disorder and/or aortic regurgitation. On the contrary, patients in South East countries and South American countries come to hospital with hypertensive disorders and it was found they are mainly involved in abdomtal aorta causing renovascular hypertension. This different clinical feature has made us run to have two international surveis. One is the clinical survey of angiographic studies under the new criteria of angiographic findings to compare among countries. Another survey is to confirm the association of HLA B-39 because in Japanese survies on HLA studies we found a statistically significant high frequency of B-39 in patients of Takayasu arteritis, as compared with healthy controls. However, as compared with the frequency of B52 in Takayasu arteritis, it is too small number of patients to speculate its association to the etiology.
It is known that frequency of B39 is larger in Amerindians and indian peoples as compared with that in Japanese. Comparative studies of HLA B-39 and clinical significances among countries have just started since 1996.
Further fruitful results have been much expected. Less