| Project/Area Number |
06042011
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Kagoshima University |
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Principal Investigator |
SONODA Shunro Kagoshima University Faculty of Medicine, 医学部・ウイルス学, 教授 (40036463)
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| Co-Investigator(Kenkyū-buntansha) |
VERONESI Ricardo Mogi Das Crucez University, Brazil, 名誉教授
GOMEZ Luis hurtado Bolivian Academy of Medicine, Bolivia, 名誉教授
HARRINGTON W マイアミ大学, 医学部内科学, 助教授
ZANINOVIC Vladimir University of Valle, Clombia, 医学部・内科学, 教授
HANCHARD Barrie University of West Indies, Jamaica, 医学部・病理学, 助教授
YASHIKI Shinji Kagoshima University Faculty of Medicine, 医学部・ウイルス学, 助手 (40182315)
FUJIYOSHI Toshinobu Kagoshima University Faculty of Medicine, 医学部・ウイルス学, 助教授 (50173480)
TAKEZAKI Toshiro Aich Cancer Center Research Instute, 主任研究員 (50227013)
MIURA Tomoyuki Kyoto University Instute for Virus Rearch, ウイルス研究所, 助手 (40202337)
HAYAMI Masanori Kyoto University Instute for Virus Rearch, ウイルス研究所, 教授 (40072946)
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| Project Period (FY) |
1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1994: ¥4,800,000 (Direct Cost: ¥4,800,000)
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| Keywords | HTLV-I / II / ATL / HAM / TSP / Infective dermatitis / Japanese / Blacks / Andean natives |
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| Research Abstract |
Our project studied prevalence of HTLV-I/II-associated diseases in Jamaica, Colombia and Bolivia. A patient with HTLV-I-associated infective dermatitis was found in Jamaican black children. Both ATL and HAM/TSP were found in Colombian black population. A native Andean was found to caryy HTLV-I whose subtype was exactly same as that of Japanese HTLV-I carrier. A Bolivian mestizo mixbred with Andes native and Spanish Caucasian was found to be HAM/TSP.The virus of this patient was also the subtype of Japanese HTLV-I.
HLA-DRB1^*DQB1^*of Jamaican infective dermatitis patient was the sames as those of Japanese HAM/TSP,indicating that a particular HLA-DRB1^*DQB1 type was cosmoplitan for HAM/TSP patients of various ethnic groups. On the other hand, the black patients with ATL or HAM/TSP showed a unique HLA background (DRB1^*DQB1^*07-0201) which was not present among Japanese ATL and HAM/TSP.Thus, two categories of HLA types were associated with ATL and HAM/TSP in the world. Of most interest was the evidence that a Bolivian mestizo HAM/TSP patient had a pair of two HLA haplotypes, one was Mongoroid trait and the other was Caucasoid origin. These results suggested that the HTLV-I carriers and patients maight have came from Africa and Mongoroid leneages and developed ATL and HAM/TSP as well as infective dermatitis. The ethnic susceptibility to ATL,HAM/TSP or other category of diseases may be determined by HLA polymerphism.
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