Grant-in-Aid for Overseas Scientific Survey.
|Research Institution||Kyoto University|
大東 繁 京都大学, 農学部, 教授
OHIGASHI Hajime Kyoto University, Professor, 農学部, 教授 (80026583)
バランサード ガイ マルセーユ大学, 薬学部, 教授
フィリップソン デーヴィ ロンドン大学, 薬学部, 教授
ハファレ マイケル コロラド大学, 人類学部, 准教授
川中 正憲 国立予防衛生研究所, 寄生動物部, 室長 (50109964)
西田 利貞 京都大学, 理学部, 教授 (40011647)
小清水 弘一 近畿大学, 生物理工学部, 教授 (90026518)
KAWANAKA Masanori Natrional Institute of Health, Chief Researcher
HUFFMAN Michael Colorado University, Associate Professor
KOSHIMIZU Koichi Kinki University, Professor
NISHIDA Toshisada Kyoto University, Professor
BALANSARD Guy University of Marseille, Professor
PHILLIPSON David London University, Professor
|Project Fiscal Year
1994 – 1994
Completed(Fiscal Year 1994)
|Budget Amount *help
¥3,200,000 (Direct Cost : ¥3,200,000)
Fiscal Year 1994 : ¥3,200,000 (Direct Cost : ¥3,200,000)
|Keywords||Chimpanzee / Medicinal plant / Schistosome / Plasomdium / Entamoeba / Trichomonas / Leishmania / Antiparasitic activity / チンパンジー / 薬用植物 / 住血吸虫 / マラリア / 赤痢アメーバー / トリコモナス / レシュマニア / 抗寄生虫活性|
Several medicinal plants used by chimpanzee in the wild have recently been reported. One of the most possible uses of these plants by chimpanzee is suggested to control parasite-related diseases. Hence, Such plants would be promising souces of antiparasitic agents. The aim of this study is to examine antiparasitic potentiality of the chimpanzee medicinal plants, and to identify chemically the active constituents.
Based on the long-term observation of chimpanzees' feeding behavior at the Mahale Mountain National Park, Tanzania, Nishida and Huffman newly selected ten species of possible medicinal plants used by chimpanzee. After several antiparasitic activity tests, plasmodicidal activities tested by Phillipson and Ohigashi were found in the extracts of Erythrina abyssinica, Combretum molle and Ximenia americana..E.abyssinica also showed potent amoebicidal activity. Balansard and Kawanaka found trichomonocidal activity in C.molle and Aspilia mossambicensis. Antischistosomal activities wer
e shown in the extracts of E.adyssinica, C.molle, A.mossambicensis, Lippia plicata by Kawanaka. It is, thus, suggested that the most chimpanzee medicinal plants contain antiparasitic constituents.
Ohigashi and Koshimizu have been explored further antiparasitic constituents of Vernonia amygdalina, and chemically identified new active sterois. Their antiparasitic activities were more potent than the related steroid glucosides isolated previously.
During the study term, Ohigashi visited Dr.D.Phillipson of the London Unoversity to examine plasmodicidal and amoebicidal activities. Dr.Kawanaka tested trichomonocidal and leishmanicidal activities with Dr.G.Balansard at the University of Marseille. Kawanaka presented his study at eht 8th International Congress of Parasite Association held at Izumir, Turkey. At the Cogress, he obtained valuable information on new antiparasitic assay methods. We also invited Dr.R.Elias, an Associate Professor under Dr.Balansard, during November 3rd-12th to carry out co-operative tests for antischistosomal activities. Less