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Analyses of Signal Transduction Mechanisms based on Protein Structures

Research Project

Project/Area Number 06276103
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionYokohama City University

Principal Investigator

NISHIMURA Yoshifumi  Yokohama City University, Professor, 大学院・総合理学研究科, 教授 (70107390)

Co-Investigator(Kenkyū-buntansha) MORIKAWA Kosuke  Biomolecular Engineering Institute, Chief Researcher, 構造解析部門, 部門長 (80012665)
AIMOTO Saburo  Osaka University, Professor, 蛋白質研究所, 教授 (80029967)
INAGAKI Fuyuhiko  Tokyo Metropolitan Institute of Medical Science, Researcher, 生理活性物質研究部門, 部長 (70011757)
SHIRAKAWA Masahiro  Nara Advanced Institute of Science and Technology, Assistant Professor, バイオサイセンス研究科, 助教授 (00202119)
KATAHIRA Masato  Yokohama National University, Assistant Professor, 工学部, 助教授 (70211844)
Project Period (FY) 1994 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥450,900,000 (Direct Cost: ¥450,900,000)
Fiscal Year 1998: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1997: ¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 1996: ¥38,200,000 (Direct Cost: ¥38,200,000)
Fiscal Year 1995: ¥169,200,000 (Direct Cost: ¥169,200,000)
Fiscal Year 1994: ¥230,000,000 (Direct Cost: ¥230,000,000)
KeywordsStructural Biology / X-ray Crystallography / NMR / Signal Transduction / Transcription / DNA-binding Proteins / RNA-binding Proteins / Molecular Biology
Research Abstract

To encourage collaborative studies between structural and molecular biologists, newsletters containing the research targets and conditions of each member in this project have been published with thirteen issues during 1994 - 1997. To announce research results of this project for other scientists outside the members, many symposia have been held, for example, "Roles of Protein Structures in Signal Transduction and Transcription" in 1994, "Molecular Recognition of Proteins" in 1995, "The Frontiers of Structural Biology", "Molecular Recognition Based on Protein Tertiary Structures" and "Structural Biology on Molecular Recognition of Proteins" in 1996, "Structural Biology of Signal Transduction and Molecular Recognition of DNA/RNA" and "Structural Biology of Reaction Regulation and Molecular Recognition" in 1997, and "Protein Structures in Signal Recognition' in 1998. In addition, we support the "Annual Symposium on Structural Biology" started from 1995. In 1995, a workshop on "Structure Determination of Proteins by X-ray and NMR Methods" was held for young researchers to enter the field of structural biology. For graduate and under graduate students, a Japanese book entitled "The Frontiers of Structural Biology" has been published under the editors that are the members of this project and nearly twenty members of this project have contributed to this book.

Report

(6 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (88 results)

All Other

All Publications (88 results)

  • [Publications] Nishikawa,T.: "Solution structure of the DNA-binding domain of human telomeric protein,hTRf1."Structure. 6. 1057-1065 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Katahira,M.: "Two metal-binding sites in a lead ribozyme bound to competitively by Pb and Mg.induced structural changes as revealed by NMR."Eur.J.Biochem.. 255. 727-733 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nagadoi,A.: "Solution structure of the transactivation domain of ATF-2 comprising a zinc finger-like subdomain and a flexible subdomain."J.Mol.Biol.. 287. 595-609 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ichikawa,S.: "Solution of Der f2,the Major Mite Allergen for Atopic Diseases"J.Biol.Chem.. 273. 356-360 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Li,X..: "Direct Preparation of Peptide Thioesters Using an Fmoc Solid-Phase Method."Tetrahedron Lett.. 39. 8669-8672 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ikegami,T.: "Solution structure of the DNA-and RPA-binding domain of the human repairfactor XPA."Natrue Structural Biology. 5. 701-706 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Oda,M.: "Investigation of the pytimidine preference by the c-Myb DNA-binding domain at the initial base of the consensus sequence."J.Biol.Chem.. 272. 17966-17971 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kondo,H.: "Escherichia coli positive regulator OmpR has a large loop structure at the putative RNA polymerase interaction site."Nature structural biology. 4. 28-31 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Young Ho Jeon: "Flexible Linker in the RNA Polymerase Alpha Subunit Facilitates the Independent Motion of the C-Terminal Activator Contact Domain."J.Mol.Biol.. 267. 953-962 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Iwasaki,W.: "Solution Structure of Midkine,a New Heparin-BindingGrowth Factor."The EMBO J.. 16. 6936-6946 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ogura,K.: "Conformation of Shc-derived Phosphotyrosine Containing Peptide Complexed with Grb2 SH2 Domain."J.Biomolecular NMR. 10. 273-278 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki,A.: "MKBP,a novel member of the small heat shock protein family,binds and activates the myotonic dystrophy protein kinase(DMPK)."J.Cell Biol.. 140(5). 1113-1124 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ogata,K.: "The Cavity in the Hydrophobic Core of c-Myb DNA-Binding Domain is Reserved for DNA Recognition and trans-Activation."Nature structural biology. 3. 178-187 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kamada,K.: "Sturucture of a replication-terminator protein complexed with DNA."Nature. 383. 598-603 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Arkin,I.: "Mapping the Lipid-Exposed Surfaces of Membrane Proteins."Nature Struct,Biol.. 3. 240-243 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nagadoi,A.: "Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain."Structure. 3. 1217-1224 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hojo,H.: "Preparation of S--Protected Cysteine-Containing Peptide Thioester and Its Use for the Synthesis of the Barnase-Like Domain in DNA-Directed RNA polymarase II of Saccharomyces cerevisiae."Bull.Chem.Soc.Japan. 68. 330-336 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mihara,H.: "Peptide Synthesis Mediated by Thiolsubtilisin Using peptide Thioester as Building Block."Chem.Lett.. 397-398 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Terasawa,H.: "Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos."Nature Struct.Biol.. 1. 891-897 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kohda,D.: "Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2."Structure. 2. 1029-1040 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hirao,I.: "Most compact hairpin-turn structure exerted by a short DNA fragment,d(GCGAAGC)in solution:an extraoridinary stable structure resistant to nuclease and heat."Nucleic Acids Res.. 22. 576-582 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 西村善文 他編: "構造生物学のフロンティア"共立出版. 326 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hirao, I.: "Most compact hairpin-turn structure exerted by a short DNA fragment, d(GCGAAGC) in solution : an extraoridinary stable structure resistant to nuclease and heat"Nucleic Acids Res.. 22. 576-582 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ogata, K.: "Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices"Cell. 79. 639-648 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Uno, T.: "Resonance Raman and Fourier transform infrared studies on the subunit 1 histidine mutants of the cytochrome bo complex in Escherichia coli"J. Biol. Chem.. 269. 11912-11920 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kondo, H.: "Crystallization and X-ray studies of the DNA-binding domain of OmpR protein, a positive regulator involved in activation of osmoregulatory genes in Esherichia coli"J. Mol. Biol.. 235. 8-782 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Uno, T.: "2-Methylimidazole does not bind to (octaethylporphinato)iron(IIL) chloride in the presence of methanol : A resonance Raman study"J. Amer. Chem. Soc.. 116. 4107-4108 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Katahira, M.: "A Raman spectroscopic study on conformations of DNA oligomers : A dominant effect of an AA:TT sequence over those of AT:AT and TA:TA sequences on determining conformations of DNA duplexes"Nucleosides and Nucleotides. 13. 1467-1481 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ogata,K.: "Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb"Nature Structural Biology. 2. 309-320 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nagadoi, A.: "Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain"Structure. 3. 1217-1224 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Morikawa, S.: "Determination of the nuclear magnetic resonance solution structure of a specific DNA complex of the Myb DNA-binding domain"J. biomol. NMR. 6. 294-305 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zheng, Z.: "Amide proton exchange rates in c-Myb DNA-binding domain"Quat. Magn. Res. in Biol. Med.. 3. 33-45 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Enari, M.: "Different apoptotic pathways mediated by Fas and the tumore-necrosis-factor receptor"Eur. J. Biochemistry. 236. 533-538 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ogata, K.: "The Cavity in the Hydrophobic Core of c-Myb DNA-Binding Domain is Reserved for DNA Recognition and trans-Activation"Nature structural biology. 3. 178-187 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kondo, H.: "Escherichia coli positive regulator OmpR has a large loop structure at the putative RNA polymerase interaction site"Nature structural biology. 4. 28-31 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Oda, M.: "Investigation of the pyrimidine preference by the c-Myb DNA-binding domain at the initial base of the consensus sequence"J. Biol. Chem.. 272. 17966-17971 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Izumi, Y.: "A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation"J. Biol. Chem.. 272. 7381-7389 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Oda, M.: "Identification of indispensable residues for specific DNA-binding in the imperfect tandem repeats of c-Myb R2R3"Protein Engineering. 10. 1407-1414 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mogi, T.: "Substitutions of conserved aromatic amino acid residues in subunit-l perturb the metal centers of the Escherichia coli bo-type ubiquinol oxidase"Biochemistry. 37. 1632-1639 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishikawa, T.: "Solution structure of the DNA-binding domain of human telomeric protein, hTRf1"Structure. 6. 1057-1065 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Katahira, M.: "Two metal-binding sites in a lead ribozyme bound to competitively by Pb and Mg. Induced structural changes as revealed by NMR"Eur. J. Biochem.. 255. 727-733 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nagadoi, A.: "Solution structure of the transactivation domain of ATF-2 comprising a zinc finger-like subdomain and a flexible subdomain"J. Mol. Biol.. 287. 595-609 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu, T.: "Crystallization and preliminary crystallographic data of vitelline membrane outer layer protein, IVMO-1"J. Mol. Biol.. 235. 793-794 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu, T.: "Crystal structure of vitelline membrane outer layer protein I (VMO-1) : a folding motif with homologous Greek key structures related by an internal three-fold symmetry"EMBO J.. 13. 1003-1010 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ariyoshi, M.: "Preliminary crystallograhic study of Escherichia coli RuvC Protein : an endonuclease specific for Holliday junctions"J. Mol. Biol.. 241. 281-282 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ariyoshi, M.: "Atomic structure of the RuvC resolvase : a Holliday junction-specific endonuclease from E.coli"Cell. 78. 1063-1072 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nureki, O.: "Architectures of class-defining and specific domains of glutamyl-tRNA synthetase"SCIENCE. 267. 1958-1965 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Morikawa, K.: "Crystal structure of a pyrimidine dimer-specific excision repair enzyme from bacteriophage T4 : refinement at 1.45* and X-ray analysis of the three active site mutants"J. Mol. Biol.. 249. 360-375 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Saito, A.: "Identification of four acidic amino acids that constitute the catalytic center of the RuvC Holliday junction resolvase"Proc. Natl. Acad. Sci.. 92. 7470-7474 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugiyama, S.: "The 1.8A X-ray structure of the Escherichia coli PotD protein complexed with spermidine and the mechanism of polyamine binding"Protein Science. 5. 1984-1990 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Morita, E. H.: "Implications of the zinc-finger motif found in the DNA-binding domain of the human XPA protein"Genes to Cells. 1. 437-442 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kamada, K.: "Structure of a replication-terminator protein complexed with DNA"Nature. 383. 598-603 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kashiwagi, T.: "Proposal for new catalytic roles for tow invariantresidues in Escherichia coli ribonuclease HI"Protein Engineering. 9. 857-867 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Vassylyev, D. G.: "Precluding uracil from DNA"Structure. 4. 1381-1385 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kashiwagi, T.: "The novel acidophilic structure of the killer toxin from halotolerant yeast demonstrates remarkable folding similarity with a fungal killer toxin"Structure. 5. 81-94 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aritomi, M.: "Crystal structure of rat Bcl-xL"J. Biol. Chem.. 272. 27886-27892 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishino, T.: "Functional analyses of the domain structure in the Holliday junction binding protein RuvA"Structure. Vol.6 No.1. 11-21 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Morikawa, K.: "Crystallographyic Study of Proteins involved in recombinational repair and excision repair"Prog. Nuc. Acids. Res.. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishikawa,T.: "Solution structure of the DNA-binding domain of human telomeric protein,hTRf1." Structure. 6. 1057-1065 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Katahira,M.: "Two metal-bindingsites in a lead ribozyme bound to competitively by Pb and Mg.Induced structural changes as revealed by NMR" Eur.J.Biochem.255. 727-733 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nagadoi,A.: "Solution structure of the transactivation domain of ATF-2comprising a zinc finger-like subdomain and a flexiblesubdomain." J.Mol.Biol.287. 593-607 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ichikawa,S.: "Solution of Der f2,the Mapr Mite Allergen for Atopic Diseases" J.Biol.Chem.273. 356-360 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Li,X.: "Direct Preparation of Peptide Thioesters Using an Fmoc Solid-Phase Method." Tetrahedron Lett.39. 8669-8672 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikegami,T.: "Solution structure of the DNA-and RPA-binding domain of the human repairfactor XPA." Nature Structural Biology. 5. 701-706 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Oda,M.: "Investigation of the Pyrimidine Preference by the c-Myb DNA-binding Domain at the Initial Base of the Consensus Sequence." J.Biol.Chem.272. 17966-17971 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kondo,H.: "Escherichia coli positive regulator OmpR has a large loop structure at the putative RNA polymerase interaction site." Nature structural biology. 4. 28-31 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Jeon,Y.H.: "Flexible Linker in the RNA Polymerase Alpha Subunit Facilitates the Independent Motion of the C-terminal Activator Contact Domain." J.Mol.Biol.267. 953-962 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Iwasaki,W.: "Solution structure of midkine,a new heparin-binding growth factor" The EMBO J.16. 6936-6946 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ogura,K.: "Conformation of an Shc-derived phosphotyrosine-containing peptide complexed with the Grb2 SH2 domain." J.Biomol.NMR. 10. 273-278 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suzuki,A.: "MKBP,a novel member of the small heat shock protein family,bind and activates the myotonic dystrophy protein kinase(DMPK)." J.Cell Biol.(in press). (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ogata, K.: "The cavity in the hydrophobic core of Myb DNA-binding domain is reserved for DNA recognition and trans-activation." Nature Structural Biology. 3. 178-187 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kamada, K: "Structure of a replication-terminator protein complexed with DNA" Nature. 383. 598-603 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kondo, H.: "Escherichia coli positive regulator OmpR has a large loop structure at the putative RNA polymerase interaction site." Nature Structural Biology. 3. 28-31 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Akimoto, K.: "EGF and PDGF receptors activate atypical PKCλ through phosphatidylinositol 3-kinase." EMBO J.15. 788-789 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kumasaka, T.: "Crystal structure of H2-proteinase from the venom of trimeresurus flavoviridis." J.Biochem.119. 49-57 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Atkin, I.T.: "Mapping the lipid-exposed surfaces of membrane proteins." Nature Structural Biology. 3. 240-243 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Aritaka Nagadoi: "Structura Comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain" Structure. 3. 1217-1224 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kazuhiro Ogata: "Comparisou of the free and DNA-complexed forms of the DNA-binding domain from c-Myb" Nature Structural Biolgy. 2. 309-320 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Ariyoshi: "Atomic Structure of the Ruv Cresolvase a Holliday junctionspecific endonuclease from E coli" Cell. 78. 1063-1072 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kazuhiro Ogata: "Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition heleces." Cell. 79. 639-348 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Fukuda: "Preparation of S-Protected Cvsteine-Containing Peptide Thioester and Its Use for the Svnthesis of the Barnase-Like Domain in DNA-Directed RNA Polymerase II of Saccharomvces cerevisiae." Bull.Chem.Soc.Jpn.68. 330-336 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Mihara: "Peptide Synthesis Mediated by Thiolsubtilisin Using Peptide Thioester as Building Block." Chemistry Letter. 397-398 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kazuhiro Ogata: "comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb" Nature Structural Biology. 2(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kazuhiro Ogata: "Solution Structure of a Specific DNA Complex of the Myb DNA-Binding Domain with Cooperative Recognition Helices" Cell. 79. 639-648 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hiroaki Terasawa: "Structure of the N-terminal SH3 domain of GBB2 complexed with a peptide from the guanine nadeotide releasing factor SOS" Nature Structural Biology. 1. 891-897 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Daisuke Kohda: "Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2" Structure. 2. 1029-1040 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Mariko Ariyoshi: "Atomic Structure of the ROV C resolvase:a Holiday-junction specific endonuclease from E.coli." Cell. 78. 1063-1072 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ichiro Hirao: "Most compact hair-pin turn structure exerted by a short DNA fragment,d(GCGAAGC)in solution" Nucleic Acids Res.22. 576-582 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2019-02-15  

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