がん研究の総合的推進に係る研究

• Project/Area Number: 06279101
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas (A)
• Allocation Type: Single-year Grants
• Research Institution: Japanese Foundation For Cancer Research
• Principal Investigator: 北川 知行 (財)癌研究会, 癌研究所, 所長 (50085619)
• Co-Investigator(Kenkyū-buntansha): 濱岡 利之 大阪大学, 医学部, 教授 (60028529) ; 笹月 健彦 九州大学, 生体防御医学研究所, 教授 (50014121) ; 伊藤 嘉明 京都大学, ウイルス研究所, 所長 (80004612) ; 鶴尾 隆 東京大学, 分子細胞生物学研究所, 所長 (00012667) ; 渋谷 正史 東京大学, 医科学研究所, 教授 (10107427) ; 吉田 光昭 東京大学, 医科学研究所, 教授 (80012607) ; 黒木 登志夫 昭和大学, 腫瘍分子生物学研究所, 所長 (90006073) ; 寺田 雅昭 国立がんセンター, 研究所, 所長 (10124421)
• Project Period (FY): 2000
• Project Status: Completed(Fiscal Year 2000)
• Budget Amount: ¥1,037,000,000 (Direct Cost : ¥1,037,000,000); Fiscal Year 2000 : ¥3,000,000 (Direct Cost : ¥3,000,000); Fiscal Year 1999 : ¥150,000,000 (Direct Cost : ¥150,000,000); Fiscal Year 1998 : ¥150,000,000 (Direct Cost : ¥150,000,000); Fiscal Year 1997 : ¥170,000,000 (Direct Cost : ¥170,000,000); Fiscal Year 1996 : ¥168,000,000 (Direct Cost : ¥168,000,000); Fiscal Year 1995 : ¥133,000,000 (Direct Cost : ¥133,000,000); Fiscal Year 1994 : ¥263,000,000 (Direct Cost : ¥263,000,000)
• Keywords: 文部省がん研究 / 成果とりまとめ / cancer research / steering / support / project / cohort

Research Abstract

平成6〜11年度の文部省がん重点〜特定研究の成果を、この期間の総合がん総括班員全員が協力して403ページの冊子にまとめ発行した。
発がん、がん生物、がん治療、先端がんの各領域の班員が討議の上成果のとりまとめと評価を行い、更に総合がん総括班を2回開催し、全体的立場からのまとめと評価を行った。
冊子には更に総合がんの活動に属する支援委員会、検討班、長期的研究、シンポジウム、ワークショップ等の活動も収録し、将来のがん研究の試料となることを意図した。冊子は全研究代表者と評価委員、学術審議会委員などの関係に配布した。

Research Products

• [Publications] Miyaki,M.,Kitagawa,T, et al.: "Malignant transformation and EGFR activation of immortalized mouse liver epithelial cells caused by HBV enhancer-X from a human hepatocellular carcinoma."Int.J.Cancer. 85. 518-522 (2000)
• [Publications] Kitagawa, T.et al.: "The concept of Tenju-gann or Natural-end cancer"Cancer. 83. 1061-1065 (1998)
• [Publications] Sasazuki, T.et al.: "Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor"New Engl. J. Med.. 339. 1177-1185 (1998)
• [Publications] Yoshiaki Ito et al.: "Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukermogenic derviative of acute myeloid leukemia 1"FEBS Letters. 446. 86-90 (1999)
• [Publications] Takashi Tsuruo et al.: "Production of interleukin-11 in bone-derived endothelial cells and its role in the formation of osteolytic bone metastasis"Oncogene. 16. 693-703 (1998)
• [Publications] Tadatsugu Taniguchi et al.: "Reguirement for IRF-1 in the microenvironment supporiting development of natural killer cells"Nature. 391. 700-703 (1998)
• [Publications] Masabumi Shibuya et al.: "Significant expression of Vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors"Cancer Res.. 58. 2652-2660 (1998)
• [Publications] Tomoyuki Kitagawa: "The Concept of Tenju-gann or Natural-end cancer." Cancer. 83. 1061-1065 (1998)
• [Publications] Yoshiaki Ito: "Instrinsie transcriptional activation/inhibition domains of the PEBP2 CBFα subunit revealed in the presence of the β subunit." Mol.Cell Biol.18. 2444-2454 (1998)
• [Publications] Toshiyuki Hamaoka: "IL-12-induced tumor regression correlates with in situ activity of IFN-gamma produced by tumor-infiltrating cell and its secondary induction" J.Leukoc.Biol.62. 450-457 (1997)
• [Publications] Takashi Tsuruo: "c-Jun NH_2-terminal kinase medrated activation of interleukin-1β converting enzymel CED-like protease during anticancer drug-induced apoptosis" J.Biol.Chem.272. 4631-4636 (1997)
• [Publications] Mitsuaki Yoshida: "Molecular biology of HTLV-1 : Dereglulation of host cellgene expression and cell cycle." Leukemia. 11. 14-15 (1997)
• [Publications] Masaaki Terada: "Presence of streptococcus anginosus DNA in esophageal cancer, dysplasia of esophagus, and gastric cancer." Cancer Res.58. 2991-2995 (1998)
• [Publications] Tomoyuki Kitagawa: "Predictive value of genetic diagnosis for cancer micrometastasis." Cancer. 80(8). 1393-1398 (1997)
• [Publications] Toshiyuki Hamaoka: "A defect in cell-to-cell adhesioon via integrin-fibronectin interactions in a highly metastatie tumor cell line." Jpn.J.Cancer Res.88. 64-71 (1997)
• [Publications] Toshio Kuroki: "DMSO induces apoptosis in SV40-transformed human keratinocytes,but not in normal keratinocytes." Cancer Letters. 108. 185-193 (1996)
• [Publications] Mitsuaki Yoshida: "Characterization of mRNA expression of IkBa and NF-kB subfamilies in primary adult T-cell leukemia cells." Jpn.J.Cancer.Res.89. 53-59 (1998)
• [Publications] Yoshiaki Ito: "Comparison of the human genomic structure of the Runt domain-encoding PEBP2/cBFα gene family." Gen.168. 279-280 (1996)
• [Publications] Takashi Tsuruo: "Cremophor EL reversed multiding resist ance in vitro but not in tumor-hearing mouse models." Anti-Cancer Drugs. 7. 825-832 (1996)
• [Publications] Tomoyuki Kitagawa: "A Novel clonality Assay for the Mouse : Application to Hepatocellular Carcinomas Induced With Diethylnitrosamine." Molecular Carcinogenesis. 15. 33-37 (1996)
• [Publications] Yoshiaki Ito: "Subcellular localization of the α and β subunlts of acute myeloid leukemialinked trascription facor PEBP2." Mol.Cell.Biol.15. 1651-1661 (1995)
• [Publications] Toshio Kuroki: "The nisoform of protein kinase C is localized on rough endoplasmic reticulum." Mol Cell Biol.14. 3782-3790 (1994)
• [Publications] Toshiyuki Hamaoka: "Characteri Zation of defectiveness in endogenous antigen presentation of novel murine Cells established from methylcholanthrene-induced fibrosarcomds" Immunology. 84. 153-158 (1995)
• [Publications] Mitsuaki Yoshida: "Identification of transcriptional activation domain of TREB5,a CREB/ATF family protein,tnat binds to HTLV-lenhancer." J.Biochem.117. 303-308 (1995)
• [Publications] Takashi Tsuruo: "Acute induction of adriamycin-resistance in human colon carcinoma HT-29 cells exposed to a Sublethal dose of adriamycin." Jpn.J.Cancer Res.86. 224-232 (1995)
• [Publications] 北川知行: "Frequent loss of heterozygcsity on chromosome 4 in diethylnrtrosamine-induced C3H/MSM mouse hepatocellular carcinomas." Mol.Cavcinogenesis. 13. 37-43 (1995)
• [Publications] 伊藤嘉明: "Subcellular localization of the α and β subunits of acute myeloid leukemia-linked transcription factor PEBP2." Mol.Cell Biol.15. 1651-1661 (1995)
• [Publications] 濱岡利之: "Regulatory mechanisms for production of IFN-g and TNF by anti-tumor T cell or macrophages in the tumer-bearing state." J.Immunol.154. 2281-2290 (1995)
• [Publications] 吉田光昭: "Tax protein of HTLV-1 destabilizes the complexes of NF-kB and Ik B-α and induces nuclear translocation of NF-kB for transcriptional activation" Oncogene. 10. 1199-1207 (1995)
• [Publications] 鶴尾隆: "Involvement of CD45 in adhesion and suppresion of apoptosis of mouse malignant.T-lymphoma cells." Cancer Res.55. 2186-2190 (1995)
• [Publications] 寺田雅昭: "Effective prevention of thrombocytopenia in mice using adenavirus-media ted transfer of HST-1(FGF-4) gene." J.of Clinical Investigation. 96. 1125-1130 (1995)
• [Publications] 北川知行: "Subcutaneous sarcomas of probable neuronal ortgin.In a transgenc mouse strain containing an albumin promoterfused simian viris 40 large Tantigln gene" Jpa.J.Camcer Res.85. 601-609 (1994)
• [Publications] 伊藤嘉明: "PEBP2αB/mouse AML1 consists of multiple isoforms that possess differential transactivation pctentials." Mol.Cell Biol.14(5). 3242-3252 (1994)
• [Publications] 黒木登志夫: "Cholesterol sulfate,avovel activator for the eta isoform of protein kinase C." Ceil Growth & Differentiation. 5. 943-947 (1994)
• [Publications] 濱岡利之: "Recovery of antitumor CD4^+T・cell responsiveness;suppressed in thetumor-boaving State,by release from tumor burden." J.Cancer Res.Clin.Oncol.120. 279-285 (1994)
• [Publications] 吉田光昭: "Top protein of HTLV-linteracts with the Rel homology doning NF-KBP65 and C-Bai potein bound to the NF-kB binding site and activates tranzeription" Oncogene. 9. 3099-3105 (1994)
• [Publications] 鶴尾隆: "Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell surface adhesion molecules" Cancer Res.53. 5022-5027 (1993)