| Project/Area Number |
06670737
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
NAKAGAWA Masao Kyoto Prefectural University of Medicine, Second Department of Medicine Pfofessor, 医学部, 教授 (30079785)
|
|---|
| Project Period (FY) |
1994 – 1996
|
| Project Status |
Completed (Fiscal Year 1996)
|
| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
|
|---|
| Keywords | WKY / NCrj / Coronary Hemodynamics / Fatty Acid Metabolism / Indomethacin / Neural Crest Cell / SHR / ACE Inhibitor / Angiotensin II Receptor Antagonist / 動脈管 / ACE阻害剤 / Angiotensin II阻害剤 / 心肥大 / 左室拡張能 / 冠血流速波形 / Reactive hyperemia / 冠血管予備能 / WKY.NCrj / 高血圧心 / 肥大型心筋症 / 冠動脈血流波形 / ドプラプローブ / 収縮期逆流 |
|---|
| Research Abstract |
We clarified the features of rats with hypertrophic cardiomyopathy and rats with hypertension.
1. The features of the coronary blood flow velocity pattern in WKY/NCrj resembled those of human hypertrophic cardiomyopathy (HCM). The abnormal pattern may relate to the abnormal course of the septal perforators.
2. WKY/NCrj had the abnormal fatty acid metabolism especially in anteroseptal and in posteroseptal junction which was often seen in human HCM.This abnormality may relate to the functional disorder of mitochondria.
3. We could produce the rats with cariac hypertrophy resembling human HCM morphologically and functionally by adimistering indomethacin to pregnant near-term rats.
4. We have revealed by using immunohistochestry that there was primarily basic phenotype producing cardiac anomaly in WKY/NCrj. In turn, the cardiac neural crest derived from somite 1 to 3 were disturbed to migrate at 13E ; Moreover by using TUNEL method apoptotic elimination was demonstrated to be augmented in left 6th aortic arch artery at 16-17E.
5. The effects of ACE Inhibitor and Angiotensin II receptor antagonist on cardiac hypertrophy, cardiac function, and coronary circulation in young SHR were assessed. Both drugs similarly prevented cardiac hypertrophy, impairment of left ventricular diastolic function, and impairment to hemodynamics of coronary blood flow in young SHR.
6. The effects of ACE Inhibitor and Angiotensin II Receptor Antagoniston cardiac hypertrophy, cardiac function, and coronary circulation in old SHR were also assesseing now.
|
