| Project/Area Number |
06670780
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Sinshu University |
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Principal Investigator |
KOIDE Kenichi Dpt of Pediatrics, Shinshu University School of Medicine, Associated Professor, 医学部, 助教授 (40143979)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIJO Takehiko Dpt of Pediatrics, Shinshu University School of Medicine, 医学部, 助手 (90262708)
KIKUCHI Toshimi Dpt of Pediatrics, Shinshu University School of Medicine, 医学部, 助手 (80262707)
北原 文徳 信州大学, 医学部, 助手 (10252082)
藪原 明彦 信州大学, 医学部, 助手 (20230295)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Chernoby1 accident / Radiation disasters / tumor-surveillance system / NK cell activity |
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| Research Abstract |
After the Chernoby1 Accident, a marked increase in the frequency of thyroid cancer has been reported in children in Belarus. However, little is known about alterations in immunological function after exposure to radionuclides. We carried out hematologic and immunologic screening on children in Chechersk, Belarus, where is one of the areas most seriously contaminated with a mixture of radionuclides.
Chidren living in constaminated area did not show a decrease in humorai immunity or in the number and function of T cells. By contrast, a comparative analysis of NK cell activity in children from areas with and without high ^<137>Cs levels revealed a high frequency of abnormal NK cell activity only in children from the area contaminated by radioactive fallout. In addition, neither activity nor number of NK cells was correlated with the body content of ^<137>Cs. Thus, the frequent abnormality of NK cell function may not have been due to actual internal exposure to the long-lived radionuclide.
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