Hepatic denervation : Hemodynamic changes
Grant-in-Aid for General Scientific Research (C)
|Allocation Type||Single-year Grants|
|Research Institution||Kitasato University|
SATO Koshi Kitasato Univ., Sch.of Medicine, Assoc.Professor, 医学部, 助教授 (40118815)
KAKITA Akira Kitasato Univ., Sch.of Medicine, Professor, 医学部, 教授 (90109439)
YOSHIDA Muneki Kitasato Univ., Sch.of Medicine, Assoc.Professo, 医学部, 講師 (50201017)
FURUTA Kazunori Kitasato Univ., Sch.of Medicine, Research Assoc., 医学部, 助手 (40209177)
ITO Yoshiya Kitasato Univ., Sch.of Medicine, Research Assoc., 医学部, 助手 (40203187)
TAKAHASHI Tsuyoshi Kitasato Univ.Sch.of Medicine, Asst.Prof., 医学部, 講師 (70245405)
松沢 克典 北里大学, 医学部, 助手 (70209534)
|Project Period (FY)
1994 – 1995
Completed(Fiscal Year 1995)
|Budget Amount *help
¥2,100,000 (Direct Cost : ¥2,100,000)
Fiscal Year 1995 : ¥1,000,000 (Direct Cost : ¥1,000,000)
Fiscal Year 1994 : ¥1,100,000 (Direct Cost : ¥1,100,000)
|Keywords||Hepatic denervation / Hemodynamic change / Dopamine / Liver Transplantation / 門脈血流量 / 肝動脈血流量 / 心拍出量 / 肝神経切断 / 肝移植 / 肝血流量 / 酸素飽和度|
Hepatic nerves are often removed during liver transplantation and hepato biliary surgery. At the present time, the hemodynamic condition after hepatic nerve denervation, is not clear. We assessed the hepatic hemodynamic condition and the effect of dopamine after hepatic denervation.
[Material and methods]
For this experiment, we used mongrel dogs. The dogs were anesthesized with an IV administretion of pentobarbital, then intubated with an intratrachial tube and maintained by mechanical ventilation. A midline incision was performed to open the abdomen. All visible nerves in the hepatoduodnal ligament and around the liver were removed. The mean arterial pressure (MAP), central venous pressure (CVP), pulmonary arterial pressure (PAP), pulmonary arterial wedge pressure (PAWP), cardiac output (CO), portal vein pressure (PVP), hepatic arterial flow (HAF) and hepatic tissue flow (HTF) were monitered. The dogs were divided into three groups. Group 1 : Control group 3 g/kg/min dopamine was administered without liver denervation. Group 2 : 3 g/kg/min dopamine was given 1 hour after liver denervation. Group 3 : 3 g/kg/min dopamine was given 1 week after liver denervation.
1) PVF/CO increased significantly after the administration of 3 g/kg/min dopamine in group 2 however, it did not change in group 1 and group 3.
2) HAF/CO did not change after the administration of 3 g/kg/min dopamine in group 1 and 3 however, it decreased significantly in group 2.
3) Total hepatic flow increased significantly after the administration of 3 g/kg/min dopamine in group 1 however, it did not change in group 2 and group 3.
The effects of dopamine administration are similar in group 1 and group 3. These results suggest that the denerveted hepatic nerves were regenerated 1 week after hepatic nerve denervation.
Research Output (2results)