|Budget Amount *help
¥2,100,000 (Direct Cost : ¥2,100,000)
Fiscal Year 1995 : ¥700,000 (Direct Cost : ¥700,000)
Fiscal Year 1994 : ¥1,400,000 (Direct Cost : ¥1,400,000)
[Study on Changes in the Surface Amorphous Layr of the Articular Cartilage and in the Subchondral Bone in the Unstable Rabbit Knee Joint] Two weeks after sectioning the anterior cruciate ligament and the medial collateral ligament in the right knee joint of a rabbit, the surface layr became irregular and, in places, deficient exposing the underlying collagen fibril network. Intensity of safranin-o staining in the cartilage decreased, cell clusters were formed, and the periarticular synovial tissue started replacing the cartilage. At 1.5 months, digestion of the cartilage progressed from the superficial zone to the deep zone, creating fissures and ulcers in places. From this point on, proliferation of the subchondral bone became statisti-cally significant in bone morphometry. Progression of the degenerative change with time was observed at 3 and 6 months. In this experi-mental osteoarthrosis model, chondral change including that in the surface layr became apparent at 2 weeks, while chan
ge in the subcho-dral bone became significant from 1.5 months after surgery on.
[Study on Changes in the Articular Cartilage After Scraping the Articular Surface of the Rabbit Knee Joint] Two weeks after scraping of the articular surface of a rabbit knee joint, the surface layr of the cartilage was deficient and the underlying collagen network was exposed. Intensity of safranin-O staining decreased, digestion of the collagen network started in the superficial zone, and the periarticular synovial tissue started replacing the cartilage. At 1.5 months, degenerative digestion of the cartilage progressed decreasing the thickness of the tissue and creating ulcers in places. Progression of the degenerative change with time was observed at 3 and 6 months, and at 1 year. In this study, progressive degenerative change in the articular cartilage was found after scraping of the articular surface. This finding is contrary to results of previous studies reporting the absence of effective repair or progressive degeneration in partial-thickness cartilage defects. The discrepancy may come from difference in the extent of the superficial injury which was wider in the present study than in the previous ones. Less