Activities of cat striatal and cortical neurons associated with orienting movements.
Project/Area Number |
06680801
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
神経・脳内生理学
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Research Institution | University of Tsukuba |
Principal Investigator |
OHNO Tadao Univ.of Tsukuba, Inst.Basic Med.Sci., Professor, 基礎医学系, 教授 (50010111)
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Co-Investigator(Kenkyū-buntansha) |
SUGINO Kazuyuki Univ.of Tsukuba, Inst.Basic Med.Sci., Assist.prof., 基礎医学系, 講師 (30211981)
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Project Period (FY) |
1994 – 1995
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Project Status |
Completed (Fiscal Year 1995)
|
Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
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Keywords | basal ganglia / caudate nucleus / neuronal activity / orienting movements / cognitive function / position selectivity / attention / limbic cortex / 大脳皮質 / 黒質 / 注視 / 随意運動 / 眼球運動 / 眼球運動課題 / 手がかり刺激 |
Research Abstract |
1. In order to understand the neuronal mechanism of the control of orienting movement by the basal ganglia, pattern of activities of caudate neurons associated with a visually-guided eye movement task was analyzed in the alert cat. The majority of sampled neurons, which were supposed to be mostly interneurons, showed activities related to some aspects of the task. Neurons which showed activities related to presentation of visual stimuli were classified into two groups : neurons showing activities related to physical aspects of stimuli and those showing activities related to behavioral meanings of stimuli. Neurons of the former group tended to have selectivity of the position of visual stimuli, while neurons of the latter group did not have clear position selectivity. It is likely that some caudate neurons participate in cognitive processes involved in the orienting movement of the cat. 2. Effects of attention on the incidence and latency of the caudate-induced eye movement were investig
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ated. The incidence was less and the latency was longer during attentive fixation of the eye to a visual stimulus than during incidental maintenance of the eye position to the same point. This indicates that cortical activities related to attention exert significant influences over the neuronal machinery responsible for the orienting movement. 3. Distribution pattern of cortical neurons projecting to the caudate nucleus was investigated by means of retrograde transport of HRP.Caudal parts of the head of the caudate nucleus, which are effective in inducing eye movements by electrical stimulation, tended to receive abundant afferents from the limbic cortex and caudal regions of the cortex which are supposed to be involved in spatial perception, while rostral parts, which are ineffective, tended to receive afferents from rostral cortical areas related to motor functions. 4. It is suggested that the caudate nucleus receives afferents from broad areas of the cortex, integrates a variety of information including that related to cognitive function and forms commands for the orienting movement. Less
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Report
(3 results)
Research Products
(12 results)